An Overview of Synthesis and Biological Activity of Dihydropyrimidine
Derivatives

Dudhe, Anshu Chaudhary; Dudhe, Rupesh; Porwal, Omji; katole, Gayatri

doi:10.2174/1389557521666210920120457

Cited by 5 publications

(4 citation statements)

References 40 publications

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“…The total yield of dry weight from two cuts was 4.75 t/ha in both harvests. The highest percentage of oil recorded (0.25%) during the first cut, against 0.19% in second cut 38 . Devastating effects of injurious insect-pests and diseases in N. cataria are not only harmful for the plant but also impair the quality of the produce, thus hampering its medicinal value 45 .…”

Section: Cultivationmentioning

confidence: 88%

“…Apart from this, because of its use in pharmaceutical and food industry, as well as in pet toy industry, N. cataria has been grown on a large scale. It is one of the most promising aromatic plants in Egypt 38 , Ukraine and North America 39 . ʻCR9ʼ is the first cultivar of N. cataria in North America developed specifically for commercial agricultural production with a more upright growth habit and higher biomass, essential oil and Z,E-nepetalactone yield.…”

Section: Cultivationmentioning

confidence: 99%

“…[256] CODEN (USA): JDDTAO respect reached up to 70% and 80% 38 . Row width density spacing combinations were established to provide information on cultural management.…”

Section: Cultivationmentioning

confidence: 99%

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Catnip (Nepeta cataria L.): Recent Advances in Pharmacognosy, Cultivation, Chemical Composition and Biological Activity

Ibrahim

Qayssar²,

Sardar³

et al. 2022

J. Drug Delivery Ther.

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Plant preparations are said to be medicinal or herbal when they are used to promote health beyond basic nutrition. It is indeed quite interesting to observe that our ancients were duly equipped with the vast, in depth and elaborated knowledge of drugs from the vegetable origin but unfortunately they possessed a scanty knowledge with regard to the presence of chemically pure compounds in most of them. The genus Nepeta L. (catmint), a large genus of the family Lamiaceae, is named after the ancient Italian City of Nephi It is also known as Glechoma and Cataria and it contains about 280 annual and perennial species, the majority of which are aromatic plants native to temperate Europe, Asia, North Africa, and North America. The wide variety and high content of terpenoid, flavonoid and phenolic compounds of Nepeta species provide diverse pharmacological effects, justifying its traditional utilization for medicinal purposes. Nepeta cataria (catnip or catmint, N. cataria), an aromatic perennial herb, belongs to genus Nepeta of Lamiaceae family and has been well known for its medicinal and therapeutic values. The name Cataria has been originated from Cathus, an old Latin word, which mean of cats. Like other aromatic plants which have showed flavoring and medicinal properties and act as renewable source for the same, N. cataria has also been known for its essential oil and secondary metabolites, which showed tremendous applications in pharmaceutical, agrochemical and food industries. It was shown by the different research groups that the essential oil and different extracts isolated from N. cataria have been a rich source of nepetalactones and related compounds (iridoids), which have been mainly responsible for different biological activities of the plant, viz. cat attractant, antioxidant, hepatoprotective, antidiabetic activities, as well as sedative, antidepressant, spasmolytic, anti-nociceptive and anti-inflammatory activities. Experiments show that this plant influences sexual activity, and expresses anticancer properties. Antimicrobial activity against a number of bacteria is also noted, as well as repellent and insecticidal properties. Nematodidal and allelopathic effects are also noted. This review emphasizes on latest information regarding the botany, distribution, cultivation taxonomy, traditional uses and more focused on phytochemistry, pharmacology.

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Section: Cultivationmentioning

confidence: 88%

Section: Cultivationmentioning

confidence: 99%

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Catnip (Nepeta cataria L.): Recent Advances in Pharmacognosy, Cultivation, Chemical Composition and Biological Activity

Ibrahim

Qayssar²,

Sardar³

et al. 2022

J. Drug Delivery Ther.

Self Cite

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“…It is important to note that the biological activity of dihydropyrimidines can vary depending on their chemical structure and specific substitutions on the molecule. Therefore, further research and development are needed to better understand their mechanisms of action and optimize their therapeutic potential [3,4].…”

Section: Introductionmentioning

confidence: 99%

Study of the biological properties of new chemical compounds of the pyrimidine series

Egorov,

Valiullin,

Raginov

et al. 2024

E3S Web Conf.

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In order to study the effect of a number of 6-substituted uracil derivatives on bovine embryo lung cells, experiments were conducted. According to the study, the effect of the studied substances on the cultural and morphological properties of cell was determined by taking into account their viability and proliferation index. In %, it was calculated that viability was determined by the ratio of living cells to their total number. The proliferation index was determined as the ratio of the number of proliferating cells to the number of seeded cells. At 0.1 mM concentration of the compounds studied, a decrease in LEK cell viability was recorded compared to the control group, but this was only the case for compound No. 2. When other compounds were used at doses of 0.1 mM, LEK cell viability increased by 3.0-7.0% compared to controls. Increasing the dose of the compounds studied to 1.0 mM results in a 10.0% decrease in survival in the presence of compounds No. 3 and 6, 16.0% in the presence of compounds No. 2 and 7, 19.0% in the presence of compound No. 4 and 25.0% in the presence of compounds No. 8 and 9.

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Access to Fully Substituted Dihydropyrimidines via Dual Copper/Photoredox‐Catalyzed Domino Annulation of Oxime Esters and Imines

Cao

Teng

et al. 2022

Adv Synth Catal

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A domino cyclization of oxime esters and imines has been achieved by dual photoredox/ copper catalysis. A variety of structurally diverse fully substituted dihydropyrimidines have been forged in 37-88% yields at room temperature. This synthetic protocol provides N-heterocycles with high molecular complexity and functional group diversity. The present reaction is amenable to gramscale synthesis, which is expected to find potential applications in organic synthesis and drug discovery. A plausible reaction mechanism is proposed.

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An Overview of Synthesis and Biological Activity of Dihydropyrimidine Derivatives

Cited by 5 publications

References 40 publications

Catnip (Nepeta cataria L.): Recent Advances in Pharmacognosy, Cultivation, Chemical Composition and Biological Activity

Catnip (Nepeta cataria L.): Recent Advances in Pharmacognosy, Cultivation, Chemical Composition and Biological Activity

Study of the biological properties of new chemical compounds of the pyrimidine series

Access to Fully Substituted Dihydropyrimidines via Dual Copper/Photoredox‐Catalyzed Domino Annulation of Oxime Esters and Imines

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