An Overview of Smart Characteristics of Smart Polymers

Lakshmi, K. N. S. V.

doi:10.20959/wjpps20176-9307

Cited by 1 publication

(3 citation statements)

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“…The results in table 5 reveal that the methods are successful for the determination of drugs and that the excipients in the dosage forms do not interfere. The results were compared to the available validated reported [1][2][3][4][5][6][7][8][9][10][11][12][13][14][15][16][17][18] methods on each drug and the results agree well with the claim and also are in agreement with the results obtained by the literature method. Statistical evaluation results were used to test the accuracy by Student's t-test and precision by F-test (Table 6) which revealed no significant change was observed between the literature method and proposed method at the 95 % confidence level with reference to accuracy and precision.…”

Section: Application To Formulationssupporting

confidence: 82%

“…Thorough literature studies acknowledged that various methods are reported for the quantification of BSN both in finished dosage forms and biological fluids, such as Spectrophotometry [3], RP-HPLC [4,5] and HPTLC [6].…”

Section: Fig 1: Structure Of Bosentanmentioning

confidence: 99%

“…These results accuracy is comparable with other established quantification methods. Pharmaceutical samples in any physical state can be scanned and averaged up to 49 times in less than one minute by using this technique at a high wavelength precision with a high resolution Moreover, statistical analysis based on the spectral information obtained can be automatically done by the selection of the IR region in terms of peak area, peak height or peak ratio which is most suitable for quantitative determination [19][20][21][22][23]. Objective: To develop simple, environment friendly, rapid, accurate and cost effective FT-IR methods for the quantification of BSN, DSD and FNZ in bulk and marketed formulations.…”

Section: Fig 3: Structure Of Flunarizine Dihydrochloridementioning

confidence: 99%

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Ft-Ir Spectroscopic Approach for the Quantitative Analysis of Few Commercial Drugs in Bulk and Pharmaceutical Formulations

Balusani¹

2022

JASR

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Simple, environment-friendly, rapid, accurate and cost effective Fourier Transform Infrared Spectroscopic (FT-IR) methods have been developed for the quantification of Bosentan (BSN), Desloratadine (DSD) and Flunarizine (FNZ) in bulk and marketed formulations. These drugs were estimated by several techniques and a new method has been developed by using FT-IR technique. The methods were developed on the basis of sample concentration influences the intensity of the vibrational bands and linearity is expected between concentration and optical density. The quantity of the drug present in commercial tablets with no interference of the excipients was estimated by applying this proposed method. This method has been validated in terms of LOD, LOQ, precision, accuracy, % RSD, robustness and ruggedness. A factor affecting the absorbance viz., concentration of drug is optimized. The presence of excipients has also been examined and found no significant effect. The calibration curves are found effective for the assessment of pure drug and pharmaceuticals. These curves also can be applied in bulk drug and pharmaceutical industries.

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