An Overview of Privileged Scaffold: Quinolines and Isoquinolines in Medicinal Chemistry as Anticancer Agents

Abstract

: Cancer is one of the most difficult diseases and causes of death for many decades. Many pieces of research are continuously going on to get a solution for cancer. Quinoline and isoquinoline derivatives have shown their possibilities to work as an antitumor agent in anticancer treatment. The members of this privilege scaffold quinoline and isoquinoline have shown their controlling impacts in cancer treatment through various modes. In particular, this review suggests the current scenario of quinoline and isoquinoline derivatives as antitumor agents and refine the path of these derivatives to find and develop new drugs against an evil known as cancer.

Iodine-Promoted Formal [5+1] Annulation of 2-Vinylanilines and Thiurams: A Facile Approach to the Synthesis of 2-Aminoquinolines

“…Flash column chromatography was performed on silica gel (90 Å, 300-400 mesh). 1 H NMR spectra were recorded on a Bruker AVANCE Ⅲ NMR spectrometer (400 MHz)…”

“…Quinoline derivatives are privileged structures in medicinal chemistry and have drawn broad research interest. 1 Among these compounds, 2-aminoquinolines are especially important as they are essential substructures in an antiglioblastoma agent (Compound A ; Figure 1 ), 2 a neuronal nitric oxide synthase inhibitor (Compound B ), 3 a therapeutic candidate for colorectal cancer therapy through dual activities of wnt/β-catenin signaling inhibition and AMP-activated protein kinase (AMPK) activation (Compound C ), 4 and potent inhibitors of β-site amyloid precursor protein-cleaving enzyme 1 (BACE1) (Compound D ). 5 Consequently, intensive efforts have been devoted to syntheses of 2-aminoquinolines, and several protocols have been developed.…”

“…Quinoline derivatives are privileged structures in medicinal chemistry and have drawn broad research interest. 1 Among them, 2-aminoquinolines are especially important as they are essential sub-structures in anti-glioblastoma agent (Compound A, Fig. 1), 2 neuronal nitric oxide synthase inhibitor (Compound B, Fig.…”

Regioselective Functionalization of Quinolines through C-H Activation: A Comprehensive Review

“…Quinoline, also known as benzo[b]pyridine, is a remarkable heteroaromatic scaffold that belongs to the category of the privileged structures [ 1 , 2 , 3 ]. This structural motif can indeed be found in numerous natural products [ 4 , 5 , 6 , 7 , 8 , 9 , 10 , 11 ] and in countless drugs or pharmaceuticals with biological spectra ranging from antimalarial to anticancer activities [ 12 , 13 , 14 , 15 , 16 , 17 , 18 , 19 , 20 , 21 , 22 , 23 ]. Furthermore, it is also widely used as ligand in organometallic catalysis [ 24 , 25 , 26 , 27 , 28 , 29 , 30 , 31 ] as well as in material chemistry [ 32 , 33 , 34 , 35 , 36 , 37 , 38 , 39 , 40 ].…”

Chemo- and regioselective synthesis of C3-sulfonate esters and C4-chlorides of quinolines under metal-free conditions

“…The quinoline heterocyclic scaffold is an important structural motif that is found in many natural products, 1 pharmaceuticals, 2 materials, 3 and ligands. 4 Accordingly, the development of short routes for accessing substituted quinolines has attracted extensive attention.…”