An Overview of Organs-on-Chips Based on Deep Learning

Li, Jintao; Chen, Jie; Bai, Hua; Wang, Haiwei; Hao, Shiping; Ding, Yang; Peng, Bo; Zhang, Jing; Li, Lin; Huang, Wei

doi:10.34133/2022/9869518

Cited by 46 publications

(42 citation statements)

References 128 publications

(146 reference statements)

Supporting

Mentioning

Contrasting

Order By: Relevance

“…32 Using a liver-on-chip model, Bhise et al created a hepatocyte-spheroid-laden hydrogel that could be bioprinted directly inside the growth chamber of a bioreactor. 352 The developed bioreactor includes multiple layers of PDMS and PMMA and has three chambers connected with microchannels shown in systems. 19,342 The design of OoC model was selected in such a manner that introduced bubbles that would shift without being trapped in chambers.…”

Section: Poly(methyl Methacrylate)mentioning

confidence: 99%

“…Digital technology such as deep learning for image digitization, data analysis, and automation contribute in OoC extensively. 352 The digital organ-on-a-chip platform provides highparallelism and a low-variability analytical tool for toxicity assessment to combat cancer. 353 High-tech technologies such as biofabrication, artificial intelligence (AI), robotics, and automation benefits the OoC technology regularly.…”

Section: Trending Research Focused Technology and Limitationsmentioning

confidence: 99%

“…The PMMA devices showed a significant and reliable cytoxicity to the drug vincristine . Using a liver-on-chip model, Bhise et al created a hepatocyte-spheroid-laden hydrogel that could be bioprinted directly inside the growth chamber of a bioreactor . The developed bioreactor includes multiple layers of PDMS and PMMA and has three chambers connected with microchannels shown in systems. , …”

Section: Ooc Materialsmentioning

confidence: 99%

See 2 more Smart Citations

Advances in Organ-on-a-Chip Materials and Devices

Nahak¹,

Mishra²,

Preetam³

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

The organ-on-a-chip (OoC) paves a way for biomedical applications ranging from preclinical to clinical translational precision. The current trends in the in vitro modeling is to reduce the complexity of human organ anatomy to the fundamental cellular microanatomy as an alternative of recreating the entire cell milieu that allows systematic analysis of medicinal absorption of compounds, metabolism, and mechanistic investigation. The OoC devices accurately represent human physiology in vitro; however, it is vital to choose the correct chip materials. The potential chip materials include inorganic, elastomeric, thermoplastic, natural, and hybrid materials. Despite the fact that polydimethylsiloxane is the most commonly utilized polymer for OoC and microphysiological systems, substitute materials have been continuously developed for its advanced applications. The evaluation of human physiological status can help to demonstrate using noninvasive OoC materials in real-time procedures. Therefore, this Review examines the materials used for fabricating OoC devices, the application-oriented pros and cons, possessions for device fabrication and biocompatibility, as well as their potential for downstream biochemical surface alteration and commercialization. The convergence of emerging approaches, such as advanced materials, artificial intelligence, machine learning, three-dimensional (3D) bioprinting, and genomics, have the potential to perform OoC technology at next generation. Thus, OoC technologies provide easy and precise methodologies in cost-effective clinical monitoring and treatment using standardized protocols, at even personalized levels. Because of the inherent utilization of the integrated materials, employing the OoC with biomedical approaches will be a promising methodology in the healthcare industry.

show abstract

Section: Poly(methyl Methacrylate)mentioning

confidence: 99%

Section: Trending Research Focused Technology and Limitationsmentioning

confidence: 99%

Section: Ooc Materialsmentioning

confidence: 99%

See 1 more Smart Citation

Advances in Organ-on-a-Chip Materials and Devices

Nahak¹,

Mishra²,

Preetam³

et al. 2022

ACS Appl. Bio Mater.

View full text Add to dashboard Cite

show abstract

“…Implementing the principles of microfluidics, tissue engineering, and lab-on-a-chip (LOC) technologies together has given rise to the emerging technique of organ-on-a-chip (OOAC), which utilizes miniaturized cell-culturing microenvironments with microchannels and chambers that replicate human cells’ natural environment [ 5 ]. Some of the advantages of the OOAC platform over conventional methods are outlined in Figure 1 .…”

Section: Introductionmentioning

confidence: 99%

Breakthroughs and Applications of Organ-on-a-Chip Technology

Koyilot¹,

Natarajan²,

Hunt

et al. 2022

Cells

View full text Add to dashboard Cite

Organ-on-a-chip (OOAC) is an emerging technology based on microfluid platforms and in vitro cell culture that has a promising future in the healthcare industry. The numerous advantages of OOAC over conventional systems make it highly popular. The chip is an innovative combination of novel technologies, including lab-on-a-chip, microfluidics, biomaterials, and tissue engineering. This paper begins by analyzing the need for the development of OOAC followed by a brief introduction to the technology. Later sections discuss and review the various types of OOACs and the fabrication materials used. The implementation of artificial intelligence in the system makes it more advanced, thereby helping to provide a more accurate diagnosis as well as convenient data management. We introduce selected OOAC projects, including applications to organ/disease modelling, pharmacology, personalized medicine, and dentistry. Finally, we point out certain challenges that need to be surmounted in order to further develop and upgrade the current systems.

show abstract

“…In the past decade, there has been an increasing number of reports published about the development of microfluidic devices for testing various organs, such as the liver, kidney, brain, intestine, and heart [59]. The development of an OoC involving skin is more recent and essentially consists of using microfluidic technology, channels, and porous membranes to reconstruct the different layers of the skin [60,61].…”

Section: Introduction To Microfluidic Devices and Organ-on-chip Modelsmentioning

confidence: 99%

In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive Technology

Guichard¹,

Remoué²,

Honegger³

2022

Cosmetics

View full text Add to dashboard Cite

The skin is a protective organ, able to decode a wide range of tactile, thermal, or noxious stimuli. Some of the sensors belonging to the transient receptor potential (TRP) family, for example, TRPV1, can elicit capsaicin-induced heat pain or histamine-induced itching sensations. The sensory nerve fibers, whose soma is located in the trigeminal or the dorsal root ganglia, are able to carry signals from the skin’s sensory receptors toward the brain via the spinal cord. In some cases, in response to environmental factors, nerve endings might be hyper activated, leading to a sensitive skin syndrome (SSS). SSS affects about 50% of the population and is correlated with small-fiber neuropathies resulting in neuropathic pain. Thus, for cosmetical and pharmaceutical industries developing SSS treatments, the selection of relevant and predictive in vitro models is essential. In this article, we reviewed the different in vitro models developed for the assessment of skin and neuron interactions. In a second part, we presented the advantages of microfluidic devices and organ-on-chip models, with a focus on the first model we developed in this context.

show abstract

An Overview of Organs-on-Chips Based on Deep Learning

Cited by 46 publications

References 128 publications

Advances in Organ-on-a-Chip Materials and Devices

Advances in Organ-on-a-Chip Materials and Devices

Breakthroughs and Applications of Organ-on-a-Chip Technology

In Vitro Sensitive Skin Models: Review of the Standard Methods and Introduction to a New Disruptive Technology

Contact Info

Product

Resources

About