An overview of nanoparticle assisted laser therapy

Bayazıtoğlu, Yıldız; Kheradmand, Shiva; Tullius, Toni K.

doi:10.1016/j.ijheatmasstransfer.2013.08.018

Cited by 86 publications

(48 citation statements)

References 158 publications

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“…NPs can also have a silicon layer sandwiched between the magnetic core and the metal shell. The plasmonic properties of the metal nanoshells in conjunction with the magnetic core properties, which respond to an external magnetic field, hold potential for guided cancer therapy through a synergistic effect, including the use of laser irradiation guided by MRI [165,167,168].…”

Section: Photothermal Therapymentioning

confidence: 99%

A biotechnological perspective on the application of iron oxide nanoparticles

et al. 2016

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In recent decades, magnetic iron nanoparticles (NPs) have attracted much attention due to properties such as superparamagnetism, high surface area, large surface-to-volume ratio, and easy separation under external magnetic fields. Therefore, magnetic iron oxides have potential for use in numerous applications, including magnetic resonance imaging contrast enhancement, tissue repair, immunoassay, detoxification of biological fluids, drug delivery, hyperthermia, and cell separation. This review provides an updated and integrated focus on the fabrication and characterization of suitable magnetic iron NPs for biotechnological applications. The possible perspective and some challenges in the further development of these NPs are also discussed.

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Section: Photothermal Therapymentioning

confidence: 99%

A biotechnological perspective on the application of iron oxide nanoparticles

et al. 2016

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“…When the incident laser frequency matches the resonant frequency of the localized surface plasmons, the electrons will oscillate with maximum amplitude, known as LSPR. The resonant plasmonic frequency depends on the size, shape, and composition of the metallic NP, as well as its environment [112][113][114][115][116][117]. Figure 5(b) shows the light scattering, absorption, and extinction cross-section for 50 nm AuNP in water, showing a LSPR peak at ~530 nm.…”

Section: Laser Interaction With Plasmonic Npmentioning

confidence: 99%

Laser-assisted photoporation: fundamentals, technological advances and applications

Xiong

Samal

Demeester

et al. 2016

Advances in Physics: X

104

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Laser-assisted photoporation is a promising technique that is receiving increasing attention for the delivery of membrane impermeable nanoscopic substances into living cells. Photoporation is based on the generation of localized transient pores in the cell membrane using continuous or pulsed laser light. Increased membrane permeability can be achieved directly by focused laser light or in combination with sensitizing nanoparticles for higher throughput. Here, we provide a detailed account on the history and current state-ofthe-art of photoporation as a physical nanomaterial delivery technique. We first introduce with a detailed explanation of the mechanisms responsible for cell membrane pore formation, following an overview of experimental procedures for realizing direct laser photoporation. Next, we review the second and most recent method of photoporation that combines laser light with sensitizing NPs. The different mechanisms of pore formation are discussed and an overview is given of the various types of sensitizing nanomaterials. Typical experimental setups to achieve nanoparticlemediated photoporation are discussed as well. Finally, we discuss the biological and therapeutic applications enabled by photoporation and give our current view on this expanding research field and the challenges and opportunities that remain for the near future.

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“…Absorbed photons are transformed into phonons in a process that involves a rapid electron-phonon relaxation, followed by a phonon-phonon relaxation, resulting in an increase of the temperature of the system and by conduction to its surroundings [4][5][6], thus producing local heat (Figure 1). Several papers and reviews have already described how this has been applied to directly kill a cancer cell by hyperthermia [6][7][8][9][10]. Thus, in this article, we will focus on the application of the photothermal effect in photothermally triggered drug delivery.…”

Section: Photothermal Effect: How It Workmentioning

confidence: 99%

“…This is because human tissue absorbs very little in this region of the spectrum (wavelengths between 700 and 1100 nm, the so-called physiologically transparent region or the NIR window due to its position in the spectrum), and therefore this radiation can penetrate very well without causing harm [9]. Gold is the most commonly employed metal in these approaches due to its low inherent toxicity, as demonstrated in many assays (see the 'Toxicity & biodistribution' section at the end of this article) and because it allows for the fabrication of nanostructures that have plasmon absorptions in this region.…”

Section: Photothermal Effect: How It Workmentioning

confidence: 99%

Gold Nanoparticles for Photothermally Controlled Drug Release

Guerrero

Hassan

Escobar

et al. 2014

Nanomedicine (Lond.)

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In this article, we describe how nanoparticles work in photothermally triggered drug delivery, starting with a description of the plasmon resonance and the photothermal effect, and how this is used to release a drug. Then, we describe the four major functionalization strategies and each of their different applications. Finally, we discuss the biodistribution and toxicity of these systems and the necessary requirements for the use of gold nanoparticles for spatially and temporally controlling drug release through the photothermal effect.

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An overview of nanoparticle assisted laser therapy

Cited by 86 publications

References 158 publications

A biotechnological perspective on the application of iron oxide nanoparticles

A biotechnological perspective on the application of iron oxide nanoparticles

Laser-assisted photoporation: fundamentals, technological advances and applications

Gold Nanoparticles for Photothermally Controlled Drug Release

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