An Overview of Microparticulate Drug Delivery System and its Extensive Therapeutic Applications in Diabetes

Abstract

Microparticulate drug delivery system (MDDS) has attained much consideration in the modern era due to its effectiveness in overcoming traditional treatment problems. Microparticles are spherical particles of a diameter ranging from 10 μm to 1000 μm. Microparticles can encapsulate both water-soluble and insoluble compounds. MDDS proved their efficacy in improving drugs bioavailability, stability, targeting, and controlling their release patterns. Microparticles also offer comfort, easy administration, and improvement in patient compliance by reducing drugs toxicity and dosage frequency. This review elucidates the fabrication techniques, drug release, and therapeutic application of MDDS. Further details concerning the therapeutic applications of antidiabetic drugs-loaded microparticles were also reviewed, including controlling drugs release by gastroretention, improving drugs dissolution, reducing side effects, localizing drugs to the site of disease, improving insulin stability, natural products loaded with microparticles, sustained drug release, mucosal delivery, and administration routes. Additionally, the current situation and future prospects in developing microparticles loaded with antidiabetic drugs were discussed.

Optimizing and Evaluating the Transdermal Permeation of Hydrocortisone Transfersomes Formulation Based on Digital Analysis of the In Vitro Drug Release and Ex Vivo Studies

“…Thus, the solubility and dissolution rate of HC increased due to its incorporation into the nano lipid vesicles (transfersomes). Other studies have also proposed nano/microparti- culate delivery systems to improve the solubility and dissolution rate of lipophilic hypoglycemic drugs [ 37 ].…”

A Technical Note: on Microspheres

“…The dispersion is then crosslinked by heat or using a chemical cross linking agent such as glutaraldehyde. The type of surfactant tends to influence the size, particle size, surface morphology, drug transport, drug release, and biological properties of microspheres [11].…”

Intrathecal Pseudodelivery of Drugs in the Therapy of Neurodegenerative Diseases: Rationale, Basis and Potential Applications

“…Moreover, DDS contribute to the safety of pharmaceuticals during their whole delivery period by serving as various kinds of protective barriers that enclose them, minimizing the loss of active ingredients and any harmful impacts on patients. They are typically constructed at nanometric and micrometric levels in order to combine several qualities such as site-specificity, endurance, or external stimuli sensitivity [ 48 , 49 , 50 ].…”