An overview of maternal separation effects on behavioural outcomes in mice: Evidence from a four-stage methodological systematic review

Tractenberg, Saulo Gantes; Levandowski, Mateus Luz; Azeredo, Lucas Araújo de; Orso, Rodrigo; Roithmann, Laura Glusman; Hoffmann, Emerson S.; Brenhouse, Heather C.; Grassi‐Oliveira, Rodrigo

doi:10.1016/j.neubiorev.2016.06.021

Cited by 208 publications

(193 citation statements)

References 133 publications

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“…Disruption of mother-infant attachment has been extensively investigated to explain the long-term effects of early stressors across different species of rodents (Marco et al, 2015;Nishi, Horii-Hayashi, & Sasagawa, 2014;Tractenberg et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…MATERNAL SEPARATION, RECOGNITION MEMORY AND CADHERIN mRNA 4 Specifically, previous studies have suggested that the BALB/c is one of the most vulnerable mice strain to the MS effects later in life (Mehta & Schmauss, 2011;Millstein & Holmes, 2007;Tractenberg et al, 2016). In this context, daily-prolonged periods of maternal separation (MS) were associated with long-term neurobiological and behavioral consequences (Millstein & Holmes, 2007;Tractenberg et al, 2016;Viola et al, 2016;Wearick-Silva et al, 2016).…”

Section: Introductionmentioning

confidence: 99%

“…In this context, daily-prolonged periods of maternal separation (MS) were associated with long-term neurobiological and behavioral consequences (Millstein & Holmes, 2007;Tractenberg et al, 2016;Viola et al, 2016;Wearick-Silva et al, 2016). Notably, previous studies demonstrated that daily-prolonged periods of MS produce long-lasting effects on object recognition memory in male rodents (de Lima et al, 2011;Garcia et al, 2013;Martisova, Aisa, Guereñu, & Ramírez, 2013;Pinheiro et al, 2015).…”

Section: Introductionmentioning

confidence: 99%

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Maternal separation induces hippocampal changes in cadherin-1 (CDH-1) mRNA and recognition memory impairment in adolescent mice

Azeredo

Wearick-Silva

Viola

et al. 2017

Neurobiology of Learning and Memory

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Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

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Maternal separation induces hippocampal changes in cadherin-1 (CDH-1) mRNA and recognition memory impairment in adolescent mice

Azeredo

Wearick-Silva

Viola

et al. 2017

Neurobiology of Learning and Memory

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“…[3] Throughout this manuscript biological dichotomous 'sex' differences will be referred to, rather than the more psychosocially based continuous variable of gender. [73] Although often not specifically assessed, [188] sex-dependent differences are relevant to the presentation and severity of a number of diseases associated with ELS, including mental health and mood disorders, [2] cardiovascular disease, [120] and visceral pain. [157] vii) variable patterns of hyper-and/or hypo-activity.…”

Section: Contributing Factorsmentioning

confidence: 99%

“…[188]. Environmental manipulations such as limited bedding avoid potential confounding effects of altered temperature or nutrition and natural variations in maternal care.…”

Section: Contributing Factorsmentioning

confidence: 99%

Translational studies identify long-term impact of prior neonatal pain experience

Walker

2017

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Effect of early life stress on anxiety and depressive behaviors in adolescent mice

Chen

Wang

et al. 2020

Brain and Behavior

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Introduction Adolescence is a critical period for physical and mental development. The effect of early life stress on mood disorders has been intensively studied in adults using rodent models, but it has been less studied in adolescents. The present study aimed to examine the effect of early life stress on anxiety‐related and depression‐like behaviors in adolescent C57BL/6 mice and the sex difference. Methods C57BL/6 mice of both sexes were used, and early life stressors included maternal separation (MS, P2‐12, 4 hr per day), restraint stress (RS, P33 to 39, 4 hr per day), and their combination (MRS). Open field test, elevated plus maze, and forced swimming test were performed at different time points during adolescence and adulthood. Results It was found that MS did not affect the anxiety‐related behaviors of both males and females tested on P30‐31 and P41‐42. RS decreased the anxiety level in adolescent males but did not affect it in the females. MS, RS, and MRS all significantly increased the depression‐like behavior in adolescent males, but only MRS increased the depression‐like behavior in adolescent females. All effects on adolescent males and females did not persist into adulthood. Conclusion The present results showed that early life stress affected anxiety‐related and depression‐like behavior in adolescent mice in manners depending on the nature of stress, the developmental period, and sex.

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An overview of maternal separation effects on behavioural outcomes in mice: Evidence from a four-stage methodological systematic review

Cited by 208 publications

References 133 publications

Maternal separation induces hippocampal changes in cadherin-1 (CDH-1) mRNA and recognition memory impairment in adolescent mice

Maternal separation induces hippocampal changes in cadherin-1 (CDH-1) mRNA and recognition memory impairment in adolescent mice

Translational studies identify long-term impact of prior neonatal pain experience

Effect of early life stress on anxiety and depressive behaviors in adolescent mice

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