An overview of Human Papillomavirus (HPV) as an etiological factor of the anal cancer

Krzowska-Firych, Joanna; Lucas, Georgia; Lucas, C R; Lucas, Nicholas; Pietrzyk, Łukasz

doi:10.1016/j.jiph.2018.06.005

Cited by 45 publications

(53 citation statements)

References 35 publications

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“…Besides a necessary factor to cervical oncogenesis [9], hr-HPV infection is also a causal factor of other cancers [10,11]. Almost 90% of anal cancers are attributable to HPV, particularly HPV16, which is the most carcinogenic type in the anus [6,12].…”

Section: Introductionmentioning

confidence: 99%

High prevalence of anal high‐risk HPV infection among transwomen: estimates from a Brazilian RDS study

Jalil

Wilson

Monteiro

et al. 2021

J. Intern. AIDS Soc.

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Introduction: As the leading sexually transmitted infection worldwide, human papillomavirus (HPV) may disproportionately affect transwomen. We aimed to estimate anal HPV prevalence, especially focusing on high-risk (hr)-HPV types and evaluate their associated factors among transwomen living in Rio de Janeiro, Brazil. Methods: Transwomen enrolled in a respondent-driven sampling (RDS)-based survey conducted between August 2015 and January 2016 self-collected anal samples, which were promptly stored at minus 80°C. After DNA extraction, HPV detection and genotyping were performed using the PapilloCheck test. We estimated HPV prevalences and evaluated the correlates of anal hr-HPV infection using a regression logistic model. Results: Out of 345 transwomen, 272 (78.8%) were included in this analysis (122 [44.9%] HIV-positive). No participant had ever received HPV vaccination. Among participants enrolled, 212 (77.9%) were positive for any anal HPV type and 165 (60.7%) for hr-HPV. Most common hr-HPV were as follows: HPV16 (17.6%), HPV68 (14.7%), HPV39 (14.3%), HPV56 (12.5%), HPV51 (11.4%) and HPV52 (11.0%). HIV-positive transwomen had three times the odds of having an hr-HPV compared to HIV-negative transwomen. Participants who had a current rectal Neisseria gonorrhoeae infection had 3.7 times the odds of being coinfected with hr-HPV. Among HIV-positive transwomen, neither antiretroviral therapy use, undetectable viral load, current and nadir CD4 counts were associated with anal hr-HPV infection. Conclusions: Brazilian transwomen in our study exhibit some of the highest population-specific rates of HPV and hr-HPV. There is an urgent need to elucidate the burden of HPV infection, prevalence of HPV-related diseases and access to and uptake of HPV vaccination among transwomen, especially from low-and middle-income settings.

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Section: Introductionmentioning

confidence: 99%

High prevalence of anal high‐risk HPV infection among transwomen: estimates from a Brazilian RDS study

Jalil

Wilson

Monteiro

et al. 2021

J. Intern. AIDS Soc.

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“…Investigations on the prevalence and subtype distribution of HPV infection in Xinjiang are seldom, especially in individuals infected with multiple HPV subtypes. CA represents a momentous HPV disease burden around the world, which is associated with anal cancer, cervical cancer, penile cancer, vulva cancerand other genital cancers [22] . The samples in our study were mainly from patients with CA.…”

Section: Discussionmentioning

confidence: 99%

An analysis of infections incidence of multiple human papillomavirus (HPV) rising in cervical and genital samples

Liu

Guan

et al. 2019

Preprint

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Background : Human papillomavirus (HPV) is associated with cervical cancer and genital condyloma, which is mainly transmitted through sexual contact.Cervical HPV infection in females and genital HPV infection in males can induce epithelial proliferation on both mucosal and cutaneous surfaces. HPV is divided into high-risk (HR) and low-risk (LR) types according to their oncogenic potential. The HR geneotypes are considered as etiological factors for invasive cervical cancer in females, and the LR geneotypes are correlated with hyperplastic lesions, including external genital warts, condyloma acuminata, and so on. The aim of this study was to investigate the prevalence of HPV infection and geneotype distribution among individuals in Xinjiang Province.Methods A total of 1094 patients the etiology and species with characteristic of cervical and genital warty surface which mainly come from CA in dermatology and STD outpatient service of People's Hospital of Xinjiang Uygur Autonomous Region.Using a method of real-time uorescence quantitative PCR for the detection of human papilloma virus HPV 23 typing. ResultsThe prevalence of HPV infection was 67.46%, the most common LR-HPV subtypes were HPV-6 (16.27%), HPV-11 (4.57%), HPV-42(1.19%) and , and HR-HPV subtypes were HPV-16 (1.65%) and HPV-58(0.91%). The prevalence of HPV infection with single subtype and multiple subtypes was 32.91% and 34.55%, respectively. Among the females infected with a single HPV subtype, 26.11%were infected with a HR-HPV subtype. Among the females infected with multiple HPV subtypes, 18.52%were infected with multiple HR-HR HPV subtypes. The prevalence and subtype distribution of HPV infection showedage differences ( P =0.012), and the prevalence peak of HPV infection was observed in females aged 20-29 years (292/404, 72.28%). ConclusionThe prevalence of multiple infection was higher than singleinfection, and the prevalence varied signi cantly with age while had little association with race and gender.

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“…A number of viruses have been identified as oncogenic viruses that can directly transform normal cells into malignant tumor cells. Examples of such oncogenic viruses include: (1) Epstein-Barr virus (EBV), which is associated with a subset of Hodgkin's lymphoma [112][113][114][115][116][117], a subset of diffuse large B-cell lymphoma (DLBCL) [118], endemic Burkitt lymphoma [119], as well as nasopharyngeal carcinoma [119,120] and gastric adenocarcinoma [121]; (2) Kaposi's sarcoma-associated herpesvirus (KSHV), which is associated with Kaposi's sarcoma (KS) [122], primary effusion lymphoma (PEL) [123,124], and multicentric Castleman disease (MCD) [125]; (3) High-risk isotypes of human papillomaviruses (HPV), which can cause cervical, anal, oral, vulvar, vaginal, and penile cancers [126][127][128][129][130]; (4) Merkel cell polyomavirus (MCV), which is linked to Merkel cell carcinoma (MCC) [131]; and (5) human T-cell leukemia virus type 1 (HTLV-1) [132][133][134][135][136]. Other viruses such as hepatitis B virus (HBV) and hepatitis C virus (HCV) can indirectly cause liver cancer through chronic inflammation [137].…”

Section: Angiopoietins and Neoplasia Associated With Viral Infectionmentioning

confidence: 99%

“…(3) High-risk isotypes of human papillomaviruses (HPV), which can cause cervical, anal, oral, vulvar, vaginal, and penile cancers [126][127][128][129][130]; (4) Merkel cell polyomavirus (MCV), which is linked to Merkel cell carcinoma (MCC) [131]; and (5) human T-cell leukemia virus type 1 (HTLV-1) [132][133][134][135][136]. Other viruses such as hepatitis B virus (HBV) and hepatitis C virus (HCV) can indirectly cause liver cancer through chronic inflammation [137].…”

Section: Angiopoietins and Neoplasia Associated With Viral Infectionmentioning

confidence: 99%

Role of Angiopoietins in Development of Cancer and Neoplasia Associated with Viral Infection

2020

Cells

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Angiopoietin/tyrosine protein kinase receptor Tie-2 signaling in endothelial cells plays an essential role in angiogenesis and wound healing. Angiopoietin-1 (Ang-1) is crucial for blood vessel maturation while angiopoietin-2 (Ang-2), in collaboration with vascular endothelial growth factor (VEGF), initiates angiogenesis by destabilizing existing blood vessels. In healthy people, the Ang-1 level is sustained while Ang-2 expression is restricted. In cancer patients, Ang-2 level is elevated, which correlates with poor prognosis. Ang-2 not only drives tumor angiogenesis but also attracts infiltration of myeloid cells. The latter rapidly differentiate into tumor stromal cells that foster tumor angiogenesis and progression, and weaken the host’s anti-tumor immunity. Moreover, through integrin signaling, Ang-2 induces expression of matrix metallopeptidases (MMPs) to promote tumor cell invasion and metastasis. Many oncogenic viruses induce expression of Ang-2 to promote development of neoplasia associated with viral infection. Multiple Ang-2 inhibitors exhibit remarkable anti-tumor activities, further highlighting the importance of Ang-2 in cancer development.

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An overview of Human Papillomavirus (HPV) as an etiological factor of the anal cancer

Cited by 45 publications

References 35 publications

High prevalence of anal high‐risk HPV infection among transwomen: estimates from a Brazilian RDS study

High prevalence of anal high‐risk HPV infection among transwomen: estimates from a Brazilian RDS study

An analysis of infections incidence of multiple human papillomavirus (HPV) rising in cervical and genital samples

Role of Angiopoietins in Development of Cancer and Neoplasia Associated with Viral Infection

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