An overview of history, pathogenesis and treatment of perforated peptic ulcer disease with evaluation of prognostic scoring in adults

Prabhu, Vinod; Shivani, Aslam

doi:10.4103/2141-9248.126604

Cited by 86 publications

(72 citation statements)

References 28 publications

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“…[1] Helicobacter pylori is one of the most common causes of peptic ulcer. [1] Ulcers can also be caused or worsened by drugs such as aspirin, ibuprofen, and other NSAIDs.…”

Section: Discussionmentioning

confidence: 99%

First Report of Preoperative Imaging Diagnosis of a Surgically Confirmed Case of Valentino's Syndrome

Mahajan

Abdalla

Purayil

2014

Journal of Clinical Imaging Science

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Perforation of a duodenal ulcer (DU) into the retroperitoneal space presenting with clinical features of acute appendicitis is known as Valentino's syndrome. Post duodenal perforation, the gastric and duodenal fluids tend to settle in the right paracolic gutter causing peritonitis and clinically mimicking acute appendicitis. Only three cases of Valentino's syndrome have been reported till date in the published literature and there is only one previous report of its preoperative imaging diagnosis. To our knowledge, this is the first reported case of preoperative imaging diagnosis in a surgically confirmed case of Valentino's syndrome. In most cases, patients with undiagnosed Valentino's syndrome are operated for acute appendicitis, and on finding a normal appendix, search is made for the cause of peritonitis, which then leads to retroperitoneal perforation of duodenum. The diagnosis of Valentino's syndrome by computed tomography (CT) imaging is easy and can help in avoiding the surgery or directing the surgeon directly to the repair of the duodenal perforation. It is, therefore, essential for emergency physicians, surgeons, and radiologists to know about this entity and consider it in the differential diagnosis.

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“…[1] Helicobacter pylori is one of the most common causes of peptic ulcer. [1] Ulcers can also be caused or worsened by drugs such as aspirin, ibuprofen, and other NSAIDs.…”

Section: Discussionmentioning

confidence: 99%

First Report of Preoperative Imaging Diagnosis of a Surgically Confirmed Case of Valentino's Syndrome

Mahajan

Abdalla

Purayil

2014

Journal of Clinical Imaging Science

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“…Preferred surgery is closure of the perforation by Graham's omental patch and post-operative abtibiotics, intravenous fluids and proton pump inhibitors. 8 In conclusion, pain in the right iliac fossa may be due to several other reasons than appendicitis. Valentino's syndrome should be considered as one of the differential diagnosis even though it is rare.…”

Section: Discussionmentioning

confidence: 99%

A rare case of Valentino’s syndrome

Mohan¹,

Kabalimurthy

Balamurugan

et al. 2018

Int Surg J

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The pain in the right iliac fossa corresponds with many clinical conditions, most commonly Acute appendicitis. Rarely peptic ulcer perforation presents as pain in the right iliac fossa. This condition is called as Valentino’s syndrome. This is due to the leakage of the gastric contents from the stomach or duodenum during the perforation. This induces peritonitis and sometimes the fluids get collected in the right iliac fossa causing pain, hence mimicking appendicitis. This is the case study of a 17yr old boy with right iliac fossa pain and tenderness, vomiting, fever, all corresponding to acute appendicitis. But on surgical exploration, it was found to be duodenal perforation. Valentino’s syndrome is a very misleading condition which will lead to death if proper evaluation and timely management is not done. This study emphasis the fact that Valentino’s syndrome has to be considered as the differential diagnosis in symptoms suggestive of acute appendicitis.

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“…ЯБ развивается у 5-10% лиц, инфицированных H. pylori; роль других проульцерогенных факторов про-должает изучаться [5].…”

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“…Проходят фазы исследо-ваний более безопасные анальгетики, содержащие в структуре молекулярные фрагменты, высвобождающие NO и H 2 S, и практически лишенные отрицательного влия-ния на слизистую [5].…”

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Rabeprazole in the treatment of duodenal ulcer desease and functional dyspepsia

Русяев¹,

Шептулин²,

Шульпекова³

et al. 2018

Med. sov.

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M.Sechenov First Moscow State Medical University of the Ministry of Health of Russia (Sechenov University) RABEPRAZOLE IN THE TREATMENT OF DUODENAL ULCER DESEASE AND FUNCTIONAL DYSPEPSIA The review aims to provide a contemporary view of the pathogenesis and treatment of the most common duodenum diseasesduodenal ulcer disease (DUD) and functional dyspepsia (FD).Due to its unique structure and functions, the duodenum that anatomically represents the initial section of the small intestine differentiates itself from others. The prevalence of DUD is declining in many Western countries due to the widespread introduction of effective anti-Helicobacter therapy and a significant decrease in the prevalence of H pylori infection. However, the ideas about the poly-biological nature of DUD persists and additional risk factors continue to be studied. DUD is manifested by pain/burning feeling in the epigastric region, as well as by symptoms such as early satiety, epigastric filling after eating in the absence of obvious organic changes in the digestive system. The diagnosis of FD is based on the Rome IV criteria. The duodenum plays an important role in its pathogenesis (disorders of gastric accommodation, motor and visceral hypersensitivity). Most patients with FD have microscopic signs of inflammation of the mucous membrane of the postbulbar part of the duodenum -an increased amount of intraepithelial lymphocytes, eosinophils, and signs of increased permeability of the mucous membrane. In all likelihood, these changes are provoked by infection and / or nutritional factors, as well as by exposure to hydrochloric acid. Proton pump inhibitors (prokinetics in postprandial distress syndrome) form the basis of treatment of peptic ulcer and epigastric pain syndrome; all patients with DUD and dyspepsia syndrome infected with H. pylori receive antihelicobacter therapy. Rabeprazole that is characterized by a long and powerful effect and minimal interaction with the cytochrome 2C19 system stands out from the proton pump inhibitors. Conclusion: acid aggression plays a very important role in the pathogenesis of duodenal ulcers diseases and FD; proton pump inhibitors form the basis for the treatment of such patients both in the form of monotherapy and as part of eradication regimens.

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An overview of history, pathogenesis and treatment of perforated peptic ulcer disease with evaluation of prognostic scoring in adults

Cited by 86 publications

References 28 publications

First Report of Preoperative Imaging Diagnosis of a Surgically Confirmed Case of Valentino's Syndrome

First Report of Preoperative Imaging Diagnosis of a Surgically Confirmed Case of Valentino's Syndrome

A rare case of Valentino’s syndrome

Rabeprazole in the treatment of duodenal ulcer desease and functional dyspepsia

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