An overview of gastrointestinal mucus rheology under different pH conditions and introduction to pH-dependent rheological interactions with PLGA and chitosan nanoparticles

Ruiz-Pulido, Gustavo; Medina, Dora I.

doi:10.1016/j.ejpb.2020.12.013

Cited by 43 publications

(33 citation statements)

References 110 publications

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“…Mucus solution prepared in this fashion, and regular biological mucus, have been characterized extensively in literature using rheology 15 , 29 – 31 . While these synthesized mucus solutions are missing a great deal of components, such as proteins, lipids, salts, DNA, cells, and cellular debris, the mucin glycoprotein accounts for the majority of mucus viscoelastic properties 29 , 32 .…”

Section: Resultsmentioning

confidence: 99%

Spontaneous symmetry breaking propulsion of chemically coated magnetic microparticles

Rogowski

Kim

2022

Sci Rep

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Chemically coated micro/nanoparticles are often used in medicine to enhance drug delivery and increase drug up-take into specific areas of the body. Using a recently discovered spontaneous symmetry breaking propulsion mechanism, we demonstrate that chemically coated microparticles can swim through mucus solution under precise navigation and that certain functionalizations can dynamically change propulsion behavior. For this investigation biotin, Bitotin-PEG3-amine, and biotin chitosan were chemically functionalized onto the surfaces of magnetic microparticles using an avidin–biotin complex. These chemicals were chosen because they are used prolifically in drug delivery applications, with PEG and chitosan having well known mucoadhesive effects. Coated microparticles were then suspended in mucus synthesized from porcine stomach mucins and propelled using rotating magnetic fields. The relationship between different chemical coatings, microparticle velocity, and controllability were thoroughly explored and discussed. Results indicate that the biotinylated surface coatings altered the propulsion behavior of microparticles, with performance differences interlinked to both magnetic field properties and localized mucus properties. Precisely controlled drug carrying microparticles are envisioned to help supplant traditional drug delivery methods and enhance existing medical techniques utilizing micro/nanoparticles.

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Section: Resultsmentioning

confidence: 99%

Spontaneous symmetry breaking propulsion of chemically coated magnetic microparticles

Rogowski

Kim

2022

Sci Rep

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“…Шийкові мукоцити однорідно забарвлювались гематоксиліном та еозином у світло-рожевий колір цитоплазми та мали сплощене базофільне ядро. Позитивна ШИК-реакція в ділянці шийки залоз вказувала на наявність значної кількості муцинів, які як відомо забезпечують захисну роль тканин шлунка від дії HCL та пепсину [192,223].…”

Section: патоморфологічні та імуногістохімічні дослідженняunclassified

Non-steroidal anti-inflammatory drugs: ways to optimize therapeutic and side effects

Hladkykh¹

2022

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The monograph is focused on the accumulated experimental data regarding the innovative approach to optimization the pharmacological effects of nonsteroidal anti-inflammatory drugs by means of their combined use with drugs that have multifunctional properties. The results of our own research on the effectiveness of the use of cryopreserved placenta extract and vinboron to reduce the ulcerogenic effect of nonsteroidal anti-inflammatory drugs are summarized. New data on enhancement of therapeutic efficacy via the combined use of nonsteroidal anti-inflammatory drugs and drugs with pleiotropic pharmacological properties are presented. The monograph will be useful for a wide range of clinicians, pharmacologists, biochemists, pathophysiologists, as well as for medical, pharmacy and biology students. Tables – 43, figures – 55, bibliography – 268 references. Монографію присвячено експериментальному обґрунтуванню інноваційного підходу до вирішення актуальної проблеми сучасної медицини – оптимізації фармакологічних ефектів нестероїдних протизапальних засобів шляхом їх комбінованого застосування з препаратами, яким притаманні поліфункціональні властивості. Наведено узагальнення результатів власних досліджень ефективності використання кріоконсервованого екстракту плаценти та вінборону з метою послаблення ульцерогенної дії нестероїдних протизапальних засобів. Представлено нові дані щодо посилення терапевтичної ефективності на тлі комбінованого застосування нестероїдних протизапальних засобів та препаратів з політропними фармакологічними властивостями. Монографія буде корисною для широкого кола лікарів-клініцистів, фармакологів, біохіміків, патофізіологів, а також здобувачів закладів вищої освіти медичного, фармацевтичного та біологічного профілів. Таблиць – 43, рисунків – 55, бібліографія – 268 посилань.

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“…In the stomach, the mucus-bicarbonate layer has a peculiar role, because it has gelling property and forms a physical barrier against the self-digestion of the epithelium by HCl and pepsin. It covers the mucosal surface and ensures acid neutralization, maintaining the basophilic pH [37][38][39][40][41][42]. Mucus is a viscoelastic hydrogel with a thickness of ≥1 mm formed mostly by mucin molecules produced by goblet cells [43].…”

Section: Mucus Layermentioning

confidence: 99%

“…In a neutral environment, mucus forms a tangle of polymers with adequate conformations for the passage of gases and nutrients and constitutes a lubricant against shear stress. Under acidic conditions, mucus constitutes a weak gel with adequate elasticity against gastric acids [41].…”

Section: Mucus Layermentioning

confidence: 99%

“…If mucin production is altered and the mucus layer is damaged, infections such as H. pylori can occur [44,45]. With a greater supply of water, there is a greater separation of mucin chains, as their density formed by interactions between mucins is reduced and may compromise their bactericidal function [41]. In this sense, adequate mucin production and balanced hydration promote the ideal structural condition against pathogen invasion.…”

Section: Mucus Layermentioning

confidence: 99%

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Gastroprotective Mechanisms

Lima¹,

Lima²,

Souza³

et al. 2022

Peptic Ulcer Disease - What's New?

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Gastric ulcer (GU), a common type of peptic ulcer, results from an imbalance in the action of protective and aggressive agents. Gastroprotective mechanisms are mucus layer, gastric epithelium, gastric blood flow, gastric neurons, mucosal repair capacity, and immune system. Thus, the aim of this chapter was to provide an update on gastroprotective mechanisms. It was carried out through searches in PubMed covering the years 2016–2021 using several keywords. This survey resulted in 428 articles, of which 110 were cited in this chapter. It was reviewed the status of gastroprotective mechanisms and highlighted that mucins can act as a filter; gastric epithelial defenses are composed of the cell barrier, stem cells, and sensors on the mucosal surface; nitric oxide (NO) and hydrogen sulfide (H2S) act for gastric blood flow homeostasis (GBF); the main effector neurons in the gastric mucosa are cholinergic, nitrergic and VIPergic, and oxytocin can activate neurons; repair of the gastric mucosa requires complex biological responses; the immune system regulates the entry of antigens and pathogens. The main knowledge about gastroprotective mechanisms remains unchanged. However, we conclude that there has been progressing in this area.

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An overview of gastrointestinal mucus rheology under different pH conditions and introduction to pH-dependent rheological interactions with PLGA and chitosan nanoparticles

Cited by 43 publications

References 110 publications

Spontaneous symmetry breaking propulsion of chemically coated magnetic microparticles

Spontaneous symmetry breaking propulsion of chemically coated magnetic microparticles

Non-steroidal anti-inflammatory drugs: ways to optimize therapeutic and side effects

Gastroprotective Mechanisms

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