An overview of endothelial dysfunction in diabetes

Chirayath, Haiju H.

doi:10.15761/vdt.1000104

Cited by 2 publications

(2 citation statements)

References 42 publications

(42 reference statements)

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“…It may be possible to apply knowledge gained by studying one disease to another disease process. 6 Endothelial cell dysfunction (ECD) is a syndrome induced by diverse intrinsic and extrinsic factors that lead to disturbances in the barrier function of the vascular endothelium; in addition to its impaired anti-thrombogenic properties; angiogenic competence; proliferative capacity, disordered regulation of vascular smooth muscle tonicity, and migratory properties; and perturbed synthetic functions and impedance of neutrophils and monocytes from diapedesis. 7 Thrombocytopenia per se is associated with ECD, as evidenced by spontaneous leakage of blood at the microvascular.…”

Section: Introductionmentioning

confidence: 99%

Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation

Efat

Shoeib

Nazir

et al. 2021

Clin Appl Thromb Hemost

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Immune thrombocytopenia (ITP) appears to be a heterogeneous disease. In some patients, autoimmunity may be associated with an inflammatory process, and in other patients, low platelets may interfere with other aspects of the coagulation system. Either may predispose to thrombosis or bleeding. Further investigation of the interactions of platelets, with inflammatory cytokines and endothelial biomarkers, may help us to better understand the disease, and to recognize those patients at risk of bleeding, or conversely thrombosis. The aim of this work is to estimate von Willebrand factor (vWF) and vascular cellular adhesion molecule (V-CAM) serum levels in adult immune thrombocytopenic patients (ITP) and to decipher their possible clinical correlates. Eighty adults (≥ 18 years) were enrolled in the study; naive newly diagnosed 40 patients with primary ITP (according to the ASH 2019) and 40 sex and age-matched healthy controls, all groups are subjected for complete blood count (CBC), liver, and renal function tests, ESR, CRP, V-CAM, and VWF-Ag by enzyme-linked immunosorbent assay (ELISA). There was a highly statistically significant difference between case and control as regards to the mean level of VWF-Ag and V-CAM. vWF and V-CAM could serve as biomarkers for endothelial alterations and should be investigated as a predictor of thrombocytopenic bleeding and tailor patient management accordingly.

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Section: Introductionmentioning

confidence: 99%

Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation

Efat

Shoeib

Nazir

et al. 2021

Clin Appl Thromb Hemost

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show abstract

“…The mechanism underlying this decrease in number and functionality impairment are still poorly understood. (5) Experimental studies have shown that high glucose concentrations exposure EPC to increase superoxide anions and reduce bioavailability of nitric oxide (NO). EPC dysfunction, which may be involved in the pathogenesis of vascular complications due to endothelial insufficiency in the process of vascular generation.…”

Section: Introductionmentioning

confidence: 99%

The Number and Potency of Endothelial Progenitor Cells in Type 2 Diabetes Mellitus Patients

Darmayanti

Hendriani

Sartika³

2019

Indones Biomed J

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BACKGROUND: Type 2 Diabetes Mellitus (T2DM) is a metabolic disease, due to the disorder of insulin function, insulin secretion, or both. Long-term hyperglycemia conditions promote endothelial dysfunction precedes to the development of multiple organ dysfunctions. Endothelial progenitor cells (EPCs) and hematopoietic stem cell (HSCs) are the key cellular effectors of postnatal neovascularization and play central role in endothelial dysfunction. However, in T2DM condition, the number of apoptotic HSCs increase, it may cause the reduction in potency and number of EPCs. In diabetes, the circulating EPCs number decrease and their functionality is impaired, but mechanism underlie of this impairement is unknown. The purpose of this study was to examine the relationship duration diabetes with the number and potency of EPC cells in T2DM patients controlled and poorly controlled.METHODS: Thirty-eight T2DM male patients were classified into two group based on Indonesian Society of Endocrinology/Perkumpulan Endokrinologi Indonesia (PERKENI) criteria on T2DM. The first group was a controlled glycemic condition group (hemoglobin A1c (HbA1C) <7.0%) and the second group was a poorly controlled glycemic condition group (HbA1C >7.0%). Cluster of differentiation (CD)34+ and CD133+ expressions were used as specific marker for EPC, while quantified bright aldehyde dehydrogenase (ALDHbr) assay was used to represented the potency of EPCs.RESULTS: This study showed that in poorly controlled T2DM group the number of EPCs was lower by 24.80% (p<0.05) compared to the T2DM controlled group. Similarly, the expression of ALDHbr was lower by 43.07% (p<0.05) in poorly controlled group.CONCLUSION: There was a decrease in the number and potency of EPCs in poorly controlled T2DM patients compared to the controlled T2DM patients. There was also a strong negative correlation between the duration of diabetes and number of EPCs.KEYWORDS: ALDHbr, endothelial progenitor cells, type 2 diabetes mellitus

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An overview of endothelial dysfunction in diabetes

Cited by 2 publications

References 42 publications

Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation

Endothelial Activation and Immune Thrombocytopenia: An Engagement Waiting for Consolidation

The Number and Potency of Endothelial Progenitor Cells in Type 2 Diabetes Mellitus Patients

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