An Overview of Cyclophilins in Human Cancers

Lee, J; Ss, Kim

doi:10.1177/147323001003800501

Cited by 46 publications

(42 citation statements)

References 105 publications

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“…The majority of the N-termini 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59 60 The 379 proteins detected as being N-terminally acetylated in the IEF fractionated and PPIA is a peptidyl-prolyl cis-trans isomerase (PPIase), a family of proteins with molecular chaperone functions that also catalyse a rate-limiting protein folding process. PPIA falls directly under the transcriptional control of p53 and HIF1 alpha and has been implicated in a number of cancers with expression levels correlating to malignant transformation 33,34 .…”

Section: Discussionmentioning

confidence: 99%

Novel IEF Peptide Fractionation Method Reveals a Detailed Profile of N-Terminal Acetylation in Chemotherapy-Responsive and -Resistant Ovarian Cancer Cells

et al. 2016

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The new agreement specifically addresses what authors can do with different versions of their manuscript -e.g. use in theses and collections, teaching and training, conference presentations, sharing with colleagues, and posting on websites and repositories. The terms under which these uses can occur are clearly identified to prevent misunderstandings that could jeopardize final publication of a manuscript (Section II, Permitted Uses by Authors). Easy Reference User Guide Posting Accepted and Published Works on Websites and Repositories:A digital file of the Accepted Work and/or the Published Work may be made publicly available on websites or repositories (e.g. the Author's personal website, preprint servers, university networks or primary employer's institutional websites, third party institutional or subject-based repositories, and conference websites that feature presentations by the Author(s) based on the Accepted and/or the Published Work) under the following conditions:• It is mandated by the Author(s)' funding agency, primary employer, or, in the case of Author(s) employed in academia, university administration.• If the mandated public availability of the Accepted Manuscript is sooner than 12 months after online publication of the Published Work, a waiver from the relevant institutional policy should be sought. If a waiver cannot be obtained, the Author(s) may sponsor the immediate availability of the final Published Work through participation in the ACS AuthorChoice program-for information about this program see http://pubs.acs.org/page/policy/authorchoice/index.html.• If the mandated public availability of the Accepted Manuscript is not sooner than 12 months after online publication of the Published Work, the Accepted Manuscript may be posted to the mandated website or repository. The following notice should be included at the time of posting, or the posting amended as appropriate: "This document is the Accepted Manuscript version of a Published Work that appeared in final form in [JournalTitle], copyright © American Chemical Society after peer review and technical editing by the publisher. To access the final edited and published work see [insert ACS Articles on Request authordirected link to Published Work, see http://pubs.acs.org/page/policy/articlesonrequest/index.html]." • The posting must be for non-commercial purposes and not violate the ACS' "Ethical Guidelines to Publication of Chemical Research" (see http://pubs.acs.org/ethics).• Regardless of any mandated public availability date of a digital file of the final Published Work, Author(s) may make this file available only via the ACS AuthorChoice Program. For more information, see http://pubs.acs.org/page/policy/authorchoice/index.html. 1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21 22 23 24 25 26 27 28 29 30 31 32 33 34 35 36 37 38 39 40 41 42 43 44 45 46 47 48 49 50 51 52 53 54 55 56 57 58 59

show abstract

Section: Discussionmentioning

confidence: 99%

Novel IEF Peptide Fractionation Method Reveals a Detailed Profile of N-Terminal Acetylation in Chemotherapy-Responsive and -Resistant Ovarian Cancer Cells

et al. 2016

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“…Its expression is an independent indicator of overall survival (35) and the inhibition of AXL in MM tumours with strong AXL expression is associated with inhibition of proliferation and invasiveness (36). PPIA (CypA) is a peptidyl-prolyl cis-trans isomerase, which is upregulated in a range of solid cancers (37). CypA has been shown to stimulate cell motility and invasion by binding to the adaptor protein CrkII and preventing it from switching to its inactive form (38).…”

Section: Cancer Genomics and Proteomicsmentioning

confidence: 99%

A Proteomic Analysis of the Malignant Mesothelioma Secretome Using iTRAQ

Creaney

Dick

Leon

et al. 2017

CGP

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“…CyP-D belongs to cyclophilin proteins family that have got seven major isoforms found in subcellular compartments including the cytoplasm (CyP-D, CyP-NK, CyP-40), endo (sarco) plasmic reticulum (CyP-B, CyP-C), nucleus (CyP-E) and mitochondria (CyP-D), [109]. Mitochondrial CyP-D is a nuclear encoded protein that contains a mitochondrial targeting presequence which is cleaved after its translocation from mitochondria matrix into the inner membrane [110].…”

Section: Mitochondrial Cyp-d Opens Mpt Pore-dependent Necrosis In Td-mentioning

confidence: 99%

Alcohol and thiamine deficiency trigger differential mitochondrial transition pore opening mediating cellular death

Bâ

2017

Apoptosis

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Accumulating evidence has shown that binge-type alcohol intake in mothers interferes with thiamine deficiency (TD) to promote the fetal alcohol syndrome (FAS). Developmental alcohol or TD exposures act either synergistically or separately to reproduce FAS features e.g. intrauterine growth retardation and related microcephaly characterized by extensive cellular death induced by one another neurotoxicant. However molecular and cellular mechanisms underlying apoptosis in both alcohol and TD toxicities are unknown. The current review addresses mechanisms of apoptosis underlying alcohol and TD toxicities for further understanding FAS pathology. This study indicates two different mitochondria pathways regulating cellular death: The first mechanism may engage alcohol which activates the c-subunit ring of the F0-ATP synthase to form MPT pore-dependent apoptosis; following the second mechanism, TD activates CyP-D translocation from mitochondrial matrix towards the mitochondrial inner membrane to form MPT pore-dependent necrosis. These studies shed light upon molecular and cellular mechanisms underlying apoptosis and necrosis in developemental brain disorders related to alcohol and thiamine deficiency, in hopes of developing new therapeutic strategies for FAS medication.

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An Overview of Cyclophilins in Human Cancers

Cited by 46 publications

References 105 publications

Novel IEF Peptide Fractionation Method Reveals a Detailed Profile of N-Terminal Acetylation in Chemotherapy-Responsive and -Resistant Ovarian Cancer Cells

Novel IEF Peptide Fractionation Method Reveals a Detailed Profile of N-Terminal Acetylation in Chemotherapy-Responsive and -Resistant Ovarian Cancer Cells

A Proteomic Analysis of the Malignant Mesothelioma Secretome Using iTRAQ

Alcohol and thiamine deficiency trigger differential mitochondrial transition pore opening mediating cellular death

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