An overview of current knowledge on organophosphate di-esters in environment: Analytical methods, sources, occurrence, and behavior

Liang, Chan; Zeng, Meng-Xiao; Yuan, Xian-Zheng; Liu, Liang-Ying

doi:10.1016/j.scitotenv.2023.167656

Cited by 3 publications

(1 citation statement)

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“…Due to their physicochemical properties, OPEs are prone to leaching and volatilizing from products, thereby entering environmental medias. These compounds have been frequently detected in various environmental and biological samples, such as dust (Wu et al, 2023), atmosphere, sediments (Liang et al, 2024), water (Ai et al, 2023), foods (Chen et al, 2023), and human samples (Guo et al, 2022b). After entering the human body, most OPEs undergo metabolism to form diester or hydroxylated metabolites, which are excreted e ciently through urine (Liang et al, 2024).…”

Section: Introductionmentioning

confidence: 99%

Association between organophosphate esters individual and mixed exposure with the risk of hyperlipidemia and serum lipid levels among Chinese adults

Xu,

Xie,

Yang

et al. 2024

Preprint

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Toxicologic studies reported that organophosphate esters (OPEs) may disrupt lipid metabolism, thus affecting serum lipid levels. However, epidemiological evidences regarding the association between OPEs and the risk of hyperlipidemia (HPL) as well as serum lipid levels are scarce. In the present study, our aim was to investigate the impact of individual and mixed OPEs exposure on HPL. A total of 1981 Chinese adults were involved based on a cross-sectional design. Overall, we found a positive association between bis(1,3-dichloro-2-propyl) phosphate (BDCIPP) and the risk of HPL. Bis(1-chloro-2-propyl) phosphate (BCIPHIPP) showed a positive association with total cholesterol (TC) and low-density lipoprotein cholesterol (LDL-C). BDCIPP, diphenyl phosphate (DPHP), di-ocresyl phosphate and di-p-cresyl phosphate (Docp&Dpcp) as well as 4-hydroxyphenyl-diphenyl phosphate (4-OH-DPHP) exhibited a negative association with high-density lipoprotein cholesterol (HDL-C). In stratified analyses, BDCIPP and BCIPHIPP were significantly correlated with the increase risk of HPL in age ≤45 group. Bis (2-butoxyethyl) phosphate (BBOEP) was in relationship with an elevated risk of HPL in the subgroup of BMI < 24 kg/m2. BDCIPP was also positively associated with HPL in men. Quantile-based g computation (qgcomp) and generalized Weighted Quantile Sum Regression (gWQS) models demonstrated a negative association between OPEs mixed exposure and HDL-c in total population, as well as a positive effect of them on HPL in the subgroup of age ≤45 year, which is consistent with the individual analyses. Furthermore, joint effect analyses of revealed that participants with detected BDCIPP urinary levels and unhealthy lifestyle had the highest risk of HPL. Our findings offer evidence supporting the correlation between exposure to OPE and the risk of HPL, necessitating further prospective studies for validation.

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