An Overview of Corneal Transplantation in the Past Decade

Musa, Mutali; Zeppieri, Marco; Enaholo, Ehimare S.; Chukwuyem, Ekele; Salati, Carlo

doi:10.3390/clinpract13010024

Cited by 10 publications

(6 citation statements)

References 128 publications

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“…HSK has been found to cause neurotrophic keratitis[ 291 - 293 ]. HSK may also be a causative factor of corneal graft failure[ 294 , 295 ]. Using OCT, Ichikawa et al [ 296 ] were able to show an increase in cornea densitometry in HSV-affected eyes[ 296 ].…”

Section: Complications Of Herpes Simplex Keratitis: Corneal Scarring ...mentioning

confidence: 99%

Herpes simplex keratitis: A brief clinical overview

Musa,

Enaholo,

Aluyi-Osa

et al. 2024

World J Virol

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The aim of our minireview is to provide a brief overview of the diagnosis, clinical aspects, treatment options, management, and current literature available regarding herpes simplex keratitis (HSK). This type of corneal viral infection is caused by the herpes simplex virus (HSV), which can affect several tissues, including the cornea. One significant aspect of HSK is its potential to cause recurrent episodes of inflammation and damage to the cornea. After the initial infection, the HSV can establish a latent infection in the trigeminal ganglion, a nerve cluster near the eye. The virus may remain dormant for extended periods. Periodic reactivation of the virus can occur, leading to recurrent episodes of HSK. Factors triggering reactivation include stress, illness, immunosuppression, or trauma. Recurrent episodes can manifest in different clinical patterns, ranging from mild epithelial involvement to more severe stromal or endothelial disease. The severity and frequency of recurrences vary among individuals. Severe cases of HSK, especially those involving the stroma and leading to scarring, can result in vision impairment or even blindness in extreme cases. The cornea's clarity is crucial for good vision, and scarring can compromise this, potentially leading to visual impairment. The management of HSK involves not only treating acute episodes but also implementing long-term strategies to prevent recurrences and attempt repairs of corneal nerve endings via neurotization. Antiviral medications, such as oral Acyclovir or topical Ganciclovir, may be prescribed for prophylaxis. The immune response to the virus can contribute to corneal damage. Inflammation, caused by the body's attempt to control the infection, may inadvertently harm the corneal tissues. Clinicians should be informed about triggers and advised on measures to minimize the risk of reactivation. In summary, the recurrent nature of HSK underscores the importance of both acute and long-term management strategies to preserve corneal health and maintain optimal visual function.

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Section: Complications Of Herpes Simplex Keratitis: Corneal Scarring ...mentioning

confidence: 99%

Herpes simplex keratitis: A brief clinical overview

Musa,

Enaholo,

Aluyi-Osa

et al. 2024

World J Virol

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“…La implantación de biomateriales "libres de células" que permitan la regeneración de la córnea puede convertirse en aplicaciones humanas en el futuro, particularmente para casos de trasplantes de córnea de alto riesgo. También se ha explorado el cultivo de células endoteliales corneales humanas a partir de células madre mesenquimales que se originan en la cresta neural (Musa et al, 2023).…”

Section: Trasplante De Córnea Artificialunclassified

Alternativas medicas ante las limitaciones en el trasplante de córnea penetrante: una revisión bibliográfica

López-Carrera,

Mendoza-Rodríguez

2024

MQRInvestigar

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El trasplante de córnea, considerado exitoso pero vulnerable al rechazo inmunológico, presenta tasas de rechazo entre el 18% y el 21%. El riesgo es mayor en los primeros 6 meses, con posibilidad de reacciones hasta 4 años después. La queratoplastia endotelial tiene una incidencia de rechazo del 9%. Aunque los inmunosupresores mejoran la supervivencia, sus efectos secundarios son preocupantes. Mejoras en técnicas quirúrgicas y gestión del tejido donante han elevado tasas de supervivencia al 95%. Factores como la edad, calidad del injerto y tipo de cirugía influyen en el fallo del injerto. La escasez de donantes, agravada por el rechazo familiar, limita los trasplantes. La investigación se centra en alternativas médicas, como la queratoprótesis y técnicas emergentes, como Femtosecond láser y trasplante de membrana amniótica. La medicina regenerativa muestra promesa, especialmente con trasplantes de células epiteliales y el uso de sangre de cordón umbilical. En cuanto a córneas artificiales, opciones como Boston KPro, OOKP y queratoprótesis tipo 1 se utilizan, con Boston KPro tipo 1 siendo el más común. Técnicas emergentes, como la queratoprótesis, buscan mejorar accesibilidad. Aunque el trasplante de córnea artificial es recomendado tras fallos de injertos, se necesitan más estudios comparativos. Estrategias para prolongar la viabilidad del tejido donante y prevenir la neovascularización también se exploran. En general, la investigación continua y la evolución de técnicas ofrecen perspectivas prometedoras para mejorar los resultados de los trasplantes de córnea.

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“…In order to determine the intrasession repeatability of the device, the same optometrist performed a second measurement with the QSFree in a subgroup of 21 patients, with the measurements being spaced 3 minutes apart. To mitigate the effects of accommodation, all measurements were taken with a +2.00 D fogging lens attached to the device 22,26 (Figure 1c). This protocol was selected to minimise potential sources of uncertainty in the measurements (use of a fogging lens to reduce accommodation and occlusion of the contralateral eye to minimise peripheral distractions) while providing easy and reproducible instructions.…”

Section: Study Protocolmentioning

confidence: 99%

Ametropia detection using a novel, compact wavefront autorefractor

Hernández,

Gil,

Zaytouny

et al. 2023

Ophthalmic Physiologic Optic

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IntroductionDespite the well‐known reproducibility issues of subjective refraction, most studies evaluating autorefractors compared differences between the device and subjective refraction. This work evaluated the performance of a novel handheld Hartmann–Shack‐based autorefractor using an alternative protocol, which considered the inherent variability of subjective refraction.MethodsParticipants underwent an initial measurement with a desktop autorefractor, two subjective refractions (SR1 and SR2) and a final measurement with the QuickSee Free (QSFree) portable autorefractor. Autorefractor performance was evaluated by comparing the differences between the QSFree and each of the subjective refractions with the difference between the subjective refractions (SR1 vs. SR2) using Bland–Altman analysis and percentage of agreement.ResultsA total of 75 subjects (53 ± 14 years) were enrolled in the study. The average difference in the absolute spherical equivalent (M) between the QSFree and the SR1 and SR2 was ±0.24 and ±0.02 D, respectively, that is, very similar or smaller than the SR1 versus SR2 difference (±0.26 D). Average differences in astigmatic components were found to be negligible. The results demonstrate that differences between QSFree and both subjective refractions in J0 and J45 were within ±0.50 D for at least 96% of the measurements. The limits of agreement (LOAs) of the differences between QSFree and SR1, as well as QSFree and SR2, were higher than those observed between SR1 and SR2 for M, J0 and J45.ConclusionsA protocol was designed and validated for the evaluation of a refractive device to account for the variability of subjective refraction. This protocol was used to evaluate a novel portable autorefractor and observed a smaller difference between the device and subjective refractions than the difference between the two subjective refraction measurements in terms of mean bias error, although the standard deviation was higher.

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An Overview of Corneal Transplantation in the Past Decade

Cited by 10 publications

References 128 publications

Herpes simplex keratitis: A brief clinical overview

Herpes simplex keratitis: A brief clinical overview

Alternativas medicas ante las limitaciones en el trasplante de córnea penetrante: una revisión bibliográfica

Ametropia detection using a novel, compact wavefront autorefractor

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