An overview of collagenase-3 expression in malignant tumors and analysis of its potential value as a target in antitumor therapies

Quantitative Real-Time RT-PCR of ITGA7, SVEP1, TNS1, LPHN3, SEMA3G, KLB and MMP13 mRNA Expression in Breast Cancer

“…LPHN3-deficient mice display evidence of profound disruption at multiple monoamine-signalling levels, causing attention deficit-hyperactivity disorder (ADHD), the most common psychiatric disorder in childhood and adolescence (Wallis et al, 2012). MMP13 or collagenase-3 is a member of the matrix metalloproteinase family of endopeptidases that have potent degrading activity for degrading the major protein components of the extracellular matrix and basement membranes of the cells (Pendás et al, 2000). MMP13 is induced during invasion and metastasis of head and neck cancer, skin cancer, gastric cancer and breast cancer (Nielsen et al, 2001;Elnemr et al,2003;Luukkaa et al, 2006;Lederle et al, 2010).…”

Hepatocyte transplantation activates hepatic stellate cells with beneficial modulation of cell engraftment in the rat

“…36 Multiple cytokines upregulate MMP-13 expression. 37,38 Moreover, MMP-13 activation is regulated by MMP-14, which is poorly inhibited by TIMP-1, and was coordinately induced shortly after cell transplantation. 7 MMP-3, which was markedly upregulated after cell transplantation, degrades a variety of ECM components and may be activated by neutrophils infiltrating nonviable transplanted cells.…”

Characterization of expression of matrix metalloproteinases and tissue inhibitors of metalloproteinases in prostate cancer cell lines

“…To our knowledge our study is the first report of MMP-13 protein expression in prostate cancer cells. MMP-13 was initially isolated from breast tissues, 69 where it was overexpressed in cancers compared with benign lesions or normal mammary gland, but its production was identified as stromal. 70 Our data indicate that prostate cancer epithelial cells can express MMP-13 mRNA and secrete MMP-13 protein in the absence of stromal cells.…”