An Overview of Clinical Pharmacology of Ibuprofen

Bushra, Rabia; Aslam, Nousheen

doi:10.5001/omj.2010.49

Cited by 312 publications

(203 citation statements)

References 96 publications

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“…The selection of a nonsteroidal anti‐inflammatory drug depends on its central and peripheral actions. IBU is still one of the most effective drugs and is the NSAID of choice for managing dental pain (Bushra & Aslam ). The main mechanism of action of IBU is inhibition of cyclooxygenases, which attenuates the production of prostaglandin E2 (PGE2) (Rainsford ).…”

Section: Discussionmentioning

confidence: 99%

Efficacy of preoperative ibuprofen on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized clinical trial

et al. 2013

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Section: Discussionmentioning

confidence: 99%

Efficacy of preoperative ibuprofen on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized clinical trial

et al. 2013

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“…Ibuprofen inhibits the activity of cyclo-oxygenase I and II (COX-1 and COX-2), causing a reduced formation of precursors of prostaglandins and thromboxanes. 28,29 Herein, we report the synthesis and characterization of a new copper(II) complex based on lidocaine and ibuprofen amidephenanthroline agents. The antioxidant activity of the free ligands and copper complex are experimentally evaluated by DPPHc, ABTSc + and HOc radicals scavenging assays.…”

Section: Introductionmentioning

confidence: 99%

Experimental and theoretical evaluation on the antioxidant activity of a copper(ii) complex based on lidocaine and ibuprofen amide-phenanthroline agents

Tabrizi

Dao

2019

RSC Adv.

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A new copper(II) complex, [Cu(LC)(Ibu-phen)(H 2 O) 2 ](ClO 4 ) 2 (LC: lidocaine, Ibu-phen: ibuprofen amidephenanthroline), was synthesized and characterized. The antioxidant activities of the free ligands and the copper(II) complex were evaluated by in vitro experiments and theoretical calculations using density functional theory (DFT). Structures of the ligand Ibu-phen and the complex were identified by 1 H and 13 C NMR, FT-IR spectroscopies, mass spectrometry, thermogravimetric analysis and elemental analysis. The antioxidant potentials of LC and Ibu-phen ligands as well as copper(II) complex were also evaluated by DPPHc, ABTSc + , HOc essays and EPR spectroscopy. The experimental results show that the radical scavenging activity (RSA) at various concentrations is decreased in the following order: copper(II) complex > ascorbic acid > LC > Ibu-phen. Structural and electronic properties of the studied compounds were also analyzed by DFT approach at the M05-2X/6-311++g(2df,2p)//M05-2X/LanL2DZ level of theory. ESP maps and NPA charge distributions show that the highly negative charge regions found on the N and O heteroatoms make these sites more favorable to bind with the central copper ion.Frontier orbital distributions of copper(II) complex indicate that HOMOs are mainly localized at Ibu-phen, while its LUMOs are distributed at LC. Based on natural bond orbitals (NBO) analyses, Cu(II) ion plays as electron acceptor in binding with the two ligands and two water molecules. Thermochemical properties including bond dissociation enthalpy (BDE), ionization energy (IE), electron affinity (EA), proton affinity (PA) characterizing three common antioxidant mechanisms i.e. hydrogen transfer (HT), single electron transfer (SET) and proton loss (PL) were finally calculated in the gas phase and water solvent for two ligands and the copper(II) complex at the same level of theory. As a result, the higher EA and lower BDE and PA values obtained for copper(II) complex show that the complex shows higher antioxidant potential than the free ligands. † Electronic supplementary information (ESI) available: 1 H, 13 C NMR spectra of ligand Ibu-phen, mass spectra of ligand Ibu-phen and copper(II) complex. Cartesian coordinates and molecular enthalpies of copper(II) complex structures for different multiplicities from 2 to 8 optimized at M05-2X/LanL2DZ level of theory in the gas phase. See View Article Online a IC 50 (50% concentration of inhibition for radical scavenging activity). Values are mean AE SD of triplicates.3326 | RSC Adv., 2019,9,[3320][3321][3322][3323][3324][3325][3326][3327][3328][3329][3330][3331][3332][3333][3334][3335] This journal is

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“…Ibuprofen is a potent nonsteroidal anti-inflammatory (NSAID) drug and is commonly used to treat conditions associated with chronic arthritis, postoperative pain, and sports-related injuries. [1][2][3] Ibuprofen is a racemic mixture. Although the S(+)-enantiomer is the predominantly active enantiomer, in vivo conversion does occur.…”

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confidence: 99%

A Pharmacokinetic Study of an Ibuprofen Topical Patch in Healthy Male and Female Adult Volunteers

Lewis

Connolly

Bhatt

2018

Clinical Pharm in Drug Dev

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The pharmacokinetics of a novel locally applied ibuprofen topical patch was evaluated. Healthy subjects (n = 28) were administered a 200-mg ibuprofen patch every 24 hours for 5 days, and steady-state pharmacokinetics was determined. The amount of ibuprofen remaining in the patch following each patch removal was also assessed. The maximum steady-state drug concentration and area under the concentration curve from time 0 on day 5 (t = 0) to the 24-hours sample on day 6 were 514 ng/mL (95% CI 439 to 603 ng/mL) and 9.78 kg·h/mL (95% CI 8.43 to 11.4 kg·h/mL), respectively. Maximum ibuprofen concentration on day 5 occurred at 20 hours post-patch application. No evidence of drug accumulation was observed, and steady state was achieved between days 2 and 5. Ibuprofen levels attenuated rapidly to baseline within 24 hours after treatment discontinuation. The amount of ibuprofen remaining in the patch was high (≥80%). Treatment-emergent adverse events were generally mild, with the most prevalent being headache (n = 6; 21.4%). Only 4 TEAEs were considered related to the ibuprofen patch: paresthesia (n = 1), headache (n = 2), and pruritic rash (n = 1). The study found that the systematic absorption of ibuprofen from a 200-mg patch was low and that the levels of ibuprofen leaving the patch over a 24-hour period are consistent with levels required for therapeutic relief as shown in other studies.

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An Overview of Clinical Pharmacology of Ibuprofen

Cited by 312 publications

References 96 publications

Efficacy of preoperative ibuprofen on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized clinical trial

Efficacy of preoperative ibuprofen on the success of inferior alveolar nerve block in patients with symptomatic irreversible pulpitis: a randomized clinical trial

Experimental and theoretical evaluation on the antioxidant activity of a copper(ii) complex based on lidocaine and ibuprofen amide-phenanthroline agents

A Pharmacokinetic Study of an Ibuprofen Topical Patch in Healthy Male and Female Adult Volunteers

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