An Overview of Clinical and Pathological Characteristics and Survival Rate of Colorectal Cancer in Iran

Abstract

Context:Colorectal cancer is one of the most common cancers and the leading cause of cancer death in Iran. This study aimed to identify the clinical and pathological characteristics, as well as survival rate of colorectal cancer in Iran. Evidence Acquisition: The articles published in PubMed without language and time restrictions were included in this review. Only original clinical articles were included in the review and non-clinical studies, including cellular, molecular, genetics, and animal reports, were excluded. The case reports, letters, reviews, and clinical reports with less than 100 patients were excluded, as well. All the clinical data regarding the patients' demographics, tumor characteristics, and survival rate were collected. Results: A total of 178 studies were identified at the initial step of literature search. After applying the inclusion and exclusion criteria, 27 studies, including 37901 patients were eligible. The mean age of the patients was 57.2 years, and the male-female ratio was 1.38. Colon, rectum, and rectosigmoid junction accounted for 58%, 28%, and 14% of all colorectal primary sites, respectively. Moreover, the average proportion of the patients with stages 0-I, II, III, and IV was 9%, 39%, 36%, and 16%, respectively. Besides, tumor grades 1, 2, and 3 were reported in 52%, 37%, and 11% of the patients, respectively. Adenocarcinoma (96.8%) was the most frequent histological type. The mean and median survival rate was 80.1 and 55.2 months, respectively. Additionally, the average 5-year overall survival rate was 52.5%. Conclusions: In Iran, colorectal cancer tends to manifest at locally advanced stage with poor prognosis. Therefore, public health strategies, such as screening programs, should be planned for early detection of this aggressive neoplasm.

Clinico-Demographic Profile of Colorectal Cancer Patients in National Cancer Institute of Sabratha –Libya

“…The mean age of our patients at the time of diagnosis was 59.8 years for proximal and 55.9 years for distal colorectal cancer. This finding agrees with other studies [15,16] . The mean ages ranging from 67.9 to 69.0 years commonly reported in developed countries with a differential of about 10.0 years [17,18] .…”

Clinicodemographical assessment of colorectal cancer with emphasis on B3GALNT2, MUC1, P53 and Ki67-related risk of metastasis

“…Indeed, with IHC-based over-expression of particularly Ki67, MUC1 and overproduction B3GALNT2 proteins (but not P53) along with overexpressed Ki67, MUC1 and B3GALNT2 mRNA (but not P53 mRNA) in metastatic stage III CRC patients and a strong correlation between mRNA of Ki67, MUC1 and B3GALNT2 (but not P53 mRNA) and metastasis emphasize the potential involved of these four proteins in pathogenesis, prognosis and survival rate of CRC. This result is consistent with others [35,37]. To generate clinically useful molecular guidelines for CRC preventive measures, detection of P53, Ki67, MUC1 -and-B3GALNT2 related expressing signals should be precisely implemented.…”

The Role of Adverse Life Style Factors in the Cause of Colorectal Carcinoma in the Residents of Yazd, Iran

“…This cancer is the third and fifth common type of cancer in Iranian women and men respectively [2]. Colorectal cancer is a Family history of colorectal cancer increase the risk of colon cancer in which approximately 12 -15% of patients those with family members who have colon cancer are at an increase risk of this disease [3].…”