An Overview of Chemistry, Kinetics, Toxicity and Therapeutic Potential of Boldine in Neurological Disorders

Akotkar, Likhit; Urmila, Aswar; Ganeshpurkar, Ankit; Raj, Revathi; Pawar, Atmaram

doi:10.1007/s11064-023-03992-y

Cited by 3 publications

(2 citation statements)

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“…The investigative efforts have spotlighted boldine’s seizure-preventive capacity in murine models, challenged with convulsions induced by hydrazine and indole dioxides. Administered intraperitoneally, boldine demonstrated dose-dependent efficacy in obstructing PTZ-induced clonic and myoclonic seizures and curtailed the seizure duration in models of electric shock-induced convulsions ( Akotkar et al, 2023 ). Its modulatory effects on GABA receptors confer neuroprotection, particularly against dysfunctional GABA receptor mutations.…”

Section: Therapeutic Promise Of Natural Alkaloids Against Epilepsymentioning

confidence: 99%

“…Its modulatory effects on GABA receptors confer neuroprotection, particularly against dysfunctional GABA receptor mutations. Furthermore, boldine’s long-term administration has been associated with augmented levels of glutathione and superoxide dismutase, reflecting its intrinsic antioxidant capabilities ( Akotkar et al, 2023 ). Experimental data prove, Acute administration of non-effective dose of boldine (10 mg/kg) and vitamin C (50 mg/kg) induced anti-convulsing effects of boldine on seizure threshold ( Moezi et al, 2019 ).…”

Section: Therapeutic Promise Of Natural Alkaloids Against Epilepsymentioning

confidence: 99%

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Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy

Li,

Lin,

Duan

2024

Front. Pharmacol.

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Section: Therapeutic Promise Of Natural Alkaloids Against Epilepsymentioning

confidence: 99%

Section: Therapeutic Promise Of Natural Alkaloids Against Epilepsymentioning

confidence: 99%

Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy

Li,

Lin,

Duan

2024

Front. Pharmacol.

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Phytoconstituents Targeting the Serotonin 5-HT₃ Receptor: Promising Therapeutic Strategies for Neurological Disorders

Akotkar,

Aswar,

Ganeshpurkar

et al. 2024

ACS Pharmacol. Transl. Sci.

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The 5-hydroxytryptamine-3 receptor (5-HT3R), a subtype of serotonin receptor, is a ligand-gated ion channel crucial in mediating fast synaptic transmission in the central and peripheral nervous systems. This receptor significantly influences various neurological activities, encompassing neurotransmission, mood regulation, and cognitive processing; hence, it may serve as an innovative target for neurological disorders. Multiple studies have revealed promising results regarding the beneficial effects of these phytoconstituents and extracts on conditions such as nausea, vomiting, neuropathic pain depression, anxiety, Alzheimer’s disease, cognition, epilepsy, sleep, and dyskinesia via modulation of 5-HT3R in the pathophysiology of neurological disorder. The review delves into a detailed exploration of in silico, in vitro, and in vivo studies and clinical studies that discussed phytoconstituents acting on 5-HT3R and attenuates difficulties in neurological diseases. The diverse mechanisms by which plant-derived phytoconstituents influence 5-HT3R activity offer exciting avenues for developing innovative therapeutic interventions. Besides producing an agonistic or antagonistic effect, some phytoconstituents exert modulatory effects on 5-HT3R activity through multifaceted mechanisms. These include γ-aminobutyric acid and cholinergic neuronal pathways, interactions with neurokinin (NK)-1, NK2, serotonergic, and γ-aminobutyric acid(GABA)ergic systems, dopaminergic influences, and mediation of calcium ions release and inflammatory cascades. Notably, the phytoconstituent’s capacity to reduce oxidative stress has also emerged as a significant factor contributing to their modulatory role. Despite the promising implications, there is currently a dearth of exploration needed to understand the effect of phytochemicals on the 5-HT3R. Comprehensive preclinical and clinical research is of the utmost importance to broaden our knowledge of the potential therapeutic benefits associated with these substances.

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Pharmacology of boldine: summary of the field and update on recent advances

Sáez,

Burrell,

Cahill

et al. 2024

Front. Pharmacol.

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Over the past decade, boldine, a naturally occurring alkaloid found in several plant species including the Chilean Boldo tree, has garnered attention for its efficacy in rodent models of human disease. Some of the properties that have been attributed to boldine include antioxidant activities, neuroprotective and analgesic actions, hepatoprotective effects, anti-inflammatory actions, cardioprotective effects and anticancer potential. Compelling data now indicates that boldine blocks connexin (Cx) hemichannels (HCs) and that many if not all of its effects in rodent models of injury and disease are due to CxHC blockade. Here we provide an overview of boldine’s pharmacological properties, including its efficacy in rodent models of common human injuries and diseases, and of its absorption, distribution, pharmacokinetics, and metabolism.

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An Overview of Chemistry, Kinetics, Toxicity and Therapeutic Potential of Boldine in Neurological Disorders

Cited by 3 publications

References 117 publications

Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy

Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy

Phytoconstituents Targeting the Serotonin 5-HT₃ Receptor: Promising Therapeutic Strategies for Neurological Disorders

Pharmacology of boldine: summary of the field and update on recent advances

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An Overview of Chemistry, Kinetics, Toxicity and Therapeutic Potential of Boldine in Neurological Disorders

Cited by 3 publications

References 117 publications

Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy

Harnessing the power of natural alkaloids: the emergent role in epilepsy therapy

Phytoconstituents Targeting the Serotonin 5-HT3 Receptor: Promising Therapeutic Strategies for Neurological Disorders

Pharmacology of boldine: summary of the field and update on recent advances

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Product

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Phytoconstituents Targeting the Serotonin 5-HT₃ Receptor: Promising Therapeutic Strategies for Neurological Disorders