An overview of biorefinery-derived platform chemicals from a cellulose and hemicellulose biorefinery

Rao, T. Sudhakar; Li, Tao; Gonzalez, Michael A.

doi:10.1007/s10098-018-1568-5

Cited by 355 publications

(156 citation statements)

References 110 publications

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“…Starch is an affordable biologically renewable source of feedstock for the food, paper, pharmaceutical, and chemical industries [3][4][5]. Enzymes hydrolyze starch to its monomer glucose, which is an important and promising platform molecule employed in modern bioengineering [6]. Starch-based composites are used in food industry to develop various approaches for preserving and prolonging tastes and smells [7].…”

Section: Introductionmentioning

confidence: 99%

Changes in the Crystallinity Degree of Starch Having Different Types of Crystal Structure after Mechanical Pretreatment

et al. 2020

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This paper examines the effect of mechanical activation on the amorphization of starch having different types of crystalline structure (A-type corn starch; B-type potato starch; and C-type tapioca starch). Structural properties of the starches were studied by X-ray diffraction analysis. Mechanical activation in a planetary ball mill reduces the degree of crystallinity in proportion to pretreatment duration. C-type tapioca starch was found to have the highest degree of crystallinity. Energy consumed to achieve complete amorphization of the starches having different types of crystalline structure was measured. The kinetic parameters of the process (the effective rate constants) were determined. The rate constant and the strongest decline in the crystallinity degree after mechanical activation change in the following series: C-type starch, A-type starch, and B-type starch.

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Section: Introductionmentioning

confidence: 99%

Changes in the Crystallinity Degree of Starch Having Different Types of Crystal Structure after Mechanical Pretreatment

et al. 2020

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“…It is expected that in the near future, biorefineries increase the production of platform chemicals from renewable resources (Takkellapati, Li and Gonzalez 2018 ). The exploitation of industrial biowastes to sustain microbial cell growth and valorize biomass conversion into organic acids is one of these current trends.…”

Section: Future Perspectives For Transport Engineeringmentioning

confidence: 99%

Membrane transporters in the bioproduction of organic acids: state of the art and future perspectives for industrial applications

Soares-Silva

Ribas

Sousa-Silva

et al. 2020

FEMS Microbiology Letters

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Organic acids such as monocarboxylic acids, dicarboxylic acids or even more complex molecules such as sugar acids, have displayed great applicability in the industry as these compounds are used as platform chemicals for polymer, food, agricultural and pharmaceutical sectors. Chemical synthesis of these compounds from petroleum derivatives is currently their major source of production. However, increasing environmental concerns have prompted the production of organic acids by microorganisms. The current trend is the exploitation of industrial biowastes to sustain microbial cell growth and valorize biomass conversion into organic acids. One of the major bottlenecks for the efficient and cost-effective bioproduction is the export of organic acids through the microbial plasma membrane. Membrane transporter proteins are crucial elements for the optimization of substrate import and final product export. Several transporters have been expressed in organic acid-producing species, resulting in increased final product titers in the extracellular medium and higher productivity levels. In this review, the state of the art of plasma membrane transport of organic acids is presented, along with the implications for industrial biotechnology.

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“…Succinic acid (SA) (C 4 H 6 O 4 ), is one of the 12 highvalue bio-based chemicals listed by the US Department of Energy, and it has wide range of industrial applications [5]. Due to its versatility, the global market of SA is expanding with a demand of 50,000 metric ton in 2016 which is expected to double by 2025 [6,7].…”

Section: Introductionmentioning

confidence: 99%

Bioproduction of succinic acid from xylose by engineered Yarrowia lipolytica without pH control

Prabhu

Ledesma-Amaro

Lin

et al. 2020

Biotechnol Biofuels

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Background: Xylose is the most prevalent sugar available in hemicellulose fraction of lignocellulosic biomass (LCB) and of great interest for the green economy. Unfortunately, most of the cell factories cannot inherently metabolize xylose as sole carbon source. Yarrowia lipolytica is a non-conventional yeast that produces industrially important metabolites. The yeast is able to metabolize a large variety of substrates including both hydrophilic and hydrophobic carbon sources. However, Y. lipolytica lacks effective metabolic pathway for xylose uptake and only scarce information is available on utilization of xylose. For the economica feasibility of LCB-based biorefineries, effective utilization of both pentose and hexose sugars is obligatory. Results: In the present study, succinic acid (SA) production from xylose by Y. lipolytica was examined. To this end, Y. lipolytica PSA02004 strain was engineered by overexpressing pentose pathway cassette comprising xylose reductase (XR), xylitol dehydrogenase (XDH) and xylulose kinase (XK) gene. The recombinant strain exhibited a robust growth on xylose as sole carbon source and produced substantial amount of SA. The inhibition of cell growth and SA formation was observed above 60 g/L xylose concentration. The batch cultivation of the recombinant strain in a bioreactor resulted in a maximum biomass concentration of 7.3 g/L and SA titer of 11.2 g/L with the yield of 0.19 g/g. Similar results in terms of cell growth and SA production were obtained with xylose-rich hydrolysate derived from sugarcane bagasse. The fed-batch fermentation yielded biomass concentration of 11.8 g/L (OD 600 : 56.1) and SA titer of 22.3 g/L with a gradual decrease in pH below 4.0. Acetic acid was obtained as a main by-product in all the fermentations. Conclusion: The recombinant strain displayed potential for bioconversion of xylose to SA. Further, this study provided a new insight on conversion of lignocellulosic biomass into value-added products. To the best of our knowledge, this is the first study on SA production by Y. lipolytica using xylose as a sole carbon source.

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An overview of biorefinery-derived platform chemicals from a cellulose and hemicellulose biorefinery

Cited by 355 publications

References 110 publications

Changes in the Crystallinity Degree of Starch Having Different Types of Crystal Structure after Mechanical Pretreatment

Changes in the Crystallinity Degree of Starch Having Different Types of Crystal Structure after Mechanical Pretreatment

Membrane transporters in the bioproduction of organic acids: state of the art and future perspectives for industrial applications

Bioproduction of succinic acid from xylose by engineered Yarrowia lipolytica without pH control

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