An overview of analytical methods for enantiomeric determination of chiral pollutants in environmental samples and biota

Arenas, Marina; Martín, Julia; Santos, Juan Luís; Aparicio, Irene; Alonso, Esteban

doi:10.1016/j.trac.2021.116370

Cited by 17 publications

(18 citation statements)

References 84 publications

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“…In general, the most common analytical techniques reported for the determination of chiral pesticides in environmental samples are based on gas chromatography (GC), liquid chromatography (LC), supercritical fluid chromatography (SFC), and capillary electrophoresis (CE). Spectroscopic techniques such as Nuclear Magnetic Resonance (NMR) are in some cases useful (i.e., using cyclodextrins as chiral-solvating agents) but not applicable to the analytical determination of a wide range of chiral pesticides, especially to those containing a sulfur asymmetrical stereocenter [36][37][38][39].…”

Section: Analytical Techniques For Determination Of Chiral Pesticides...mentioning

confidence: 99%

Section: Gas Chromatography (Gc)mentioning

confidence: 99%

“…GC is often used in the determination of chiral pesticides in environmental samples due to its simplicity, high efficiency, short analysis times, good sensitivity, and reproducibility [36,40]. The main parameters that influence the chiral separation by GC are the type of chiral column, the temperature ramp rate, and the carrier gas lineal velocity [36]. In GC, the most commonly used chiral stationary phases (CSPs) are divided into three groups: amino acid derivatives and diamines, chiral metallic complexes, and cyclodextrin (CD) derivatives [41].…”

Section: Gas Chromatography (Gc)mentioning

confidence: 99%

“…Despite the above-mentioned benefits, GC has some disadvantages such as the need to derive non-volatile pesticides, the limited availability of commercial chiral GC columns, and the fact that some chiral pesticides can undergo isomeric interconversion when they are subjected to the required high temperature for volatilization [36,37]. Due to these limitations, the use of GC for the enantioselective analysis of chiral pesticides is less usual than in the case of LC.…”

Section: Gas Chromatography (Gc)mentioning

confidence: 99%

“…Liquid chromatography is the most widely used analytical technique for the enantiomeric determination of chiral pesticides from environmental samples [36,37,44]. This is due to the great number of chiral columns and chiral selectors (CSs) available on the market, its compatibility with several detectors, as well as its high versatility due to the possibility of using different elution modes (normal, reverse, polar organic, or polar ionic elution modes) [36,37]. Three LC techniques have been developed: high-performance liquid chromatography (HPLC), ultra-performance liquid chromatography (UPLC), and ultra-high performance liquid chromatography (UHPLC).…”

Section: Liquid Chromatography (Lc)mentioning

confidence: 99%

See 4 more Smart Citations

Chiral Pesticides with Asymmetric Sulfur: Extraction, Separation, and Determination in Different Environmental Matrices

López-Cabeza

Francioso

2022

Separations

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Chiral pesticides with S atoms as asymmetric centers are gaining great importance in the search for new pesticides with new modes of action. As for the rest of the chiral pesticides, the determination of the stereoisomers separately has become crucial in the environmental risks assessment of these pesticides. Therefore, the development of suitable extraction and clean-up methods as well as efficient stereoselective analytical techniques for stereoisomers determination in environmental samples is essential. Currently, liquid/solid phase extraction, microextraction, and QuEChERS-based methods are most commonly used to obtain chiral pesticides from environmental samples. Gas, liquid, and supercritical fluid chromatography together with capillary electrophoresis techniques are the most important for the determination of the stereoisomers of chiral pesticides containing S atoms in its structure. In this study, all these techniques are briefly reviewed, and the advantages and disadvantages of each are discussed

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Section: Analytical Techniques For Determination Of Chiral Pesticides...mentioning

confidence: 99%

Section: Gas Chromatography (Gc)mentioning

confidence: 99%

Section: Gas Chromatography (Gc)mentioning

confidence: 99%

Section: Gas Chromatography (Gc)mentioning

confidence: 99%

Section: Liquid Chromatography (Lc)mentioning

confidence: 99%

See 3 more Smart Citations

Chiral Pesticides with Asymmetric Sulfur: Extraction, Separation, and Determination in Different Environmental Matrices

López-Cabeza

Francioso

2022

Separations

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Chiral Mesostructured Inorganic Materials with Optical Chiral Response

Duan

Che

2023

Advanced Materials

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Fabricating chiral inorganic materials and revealing their unique quantum confinement‐determined optical chiral responses are crucial tasks in the multidisciplinary fields of chemistry, physics, and biology. The field of chiral mesostructured inorganic materials started from the synthesis of individual nanocrystals and evolved to include their assembly from metals, semiconductors, ceramics, and inorganic salts endowed with various chiral structures ranging from atomic to micron scales. This tutorial review highlights the recent research on chiral mesostructured inorganic materials, especially the novel expression of mesostructured chirality and endowed optical chiral response, and it may inspire us with new strategies for the design of chiral inorganic materials and new opportunities beyond the traditional applications of chirality. Fabrication methods for chiral mesostructured inorganic materials are classified according to chirality type, scale, and symmetry‐breaking mechanism. Special attention is given to highlight systems with original discoveries, exceptional phenomena, or unique mechanisms of optical chiral response for left‐ and right‐handedness.

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Evaluation of the Stereochemical Lability of Benzo‐Cycloheptene‐Based Drugs Endowed with Potentially Modulable Planar Chirality

Buonsenso

Colombo²,

Marchesi³

et al. 2023

Eur J Org Chem

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An experimental and theoretical study was carried out to analyze the configurational lability possessed by some of the most common drugs endowed with a central non‐planar seven‐membered cycloheptadiene ring, which confers chirality to these compounds. In fact, the absence of planarity allows the existence of two enantiomeric species that can interconvert thanks to a ring overturning mechanism. The energy barrier that opposes the inversion of the chiral tricyclic scaffold characterizing such species, which is strongly dependent on the presence of appropriate substituents on the two external cycles, has been investigated through Dynamic‐HPLC and off‐column racemization techniques, as well as through assessments based on molecular modelling approaches. Interesting indications were obtained by making targeted structural changes to allow accurate control of the stereolability characterizing the tricyclic framework.

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An overview of analytical methods for enantiomeric determination of chiral pollutants in environmental samples and biota

Cited by 17 publications

References 84 publications

Chiral Pesticides with Asymmetric Sulfur: Extraction, Separation, and Determination in Different Environmental Matrices

Chiral Pesticides with Asymmetric Sulfur: Extraction, Separation, and Determination in Different Environmental Matrices

Chiral Mesostructured Inorganic Materials with Optical Chiral Response

Evaluation of the Stereochemical Lability of Benzo‐Cycloheptene‐Based Drugs Endowed with Potentially Modulable Planar Chirality

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