An outline for the pharmacological effect of icariin in the nervous system

Jin, Jie; Wang, Hui; Hua, Xiao‐Ying; Chen, Dongjian; Huang, Chao; Chen, Zhuo

doi:10.1016/j.ejphar.2018.10.006

Cited by 88 publications

(61 citation statements)

References 147 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Icariin (ICA), chemically classified as a flavonol glycoside, is a major component of Epimedium grandiflorum [3]. Traditionally, it has been used for erectile dysfunction in ancient Chinese medicine [4].…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

et al. 2020

View full text Add to dashboard Cite

Icariin (ICA) is a flavonol glycoside that has pleiotropic pharmacological actions. It has cytotoxic effects against ovarian cancer cells and increases their chemosensitivity to chemotherapeutic drugs. Phytosomes are identified for their potential in drug delivery of cytotoxic agents. Thus, the purpose of this study was to determine the potential enhancement of ICA cytotoxicity activity in OVCAR-3 ovarian cancer cells via its formulation in phytosomes. ICA-phytosomal formulation was optimized using a Box–Behnken design. Particle size, shape, and in vitro drug release were used to characterize the optimized formula. The optimized formulation exhibited enhanced in vitro drug release. ICA-phytosomes exhibited enhanced cytotoxicity against ovarian cancer cells. Cell cycle analysis indicated accumulation of cells challenged with ICA-phytosomes in G2/M and pre-G1 phases. Staining of cells with annexin V indicated significant elevation of percentage cells with early and late apoptosis as well as total cell death. In addition, the formulation significantly disturbed mitochondrial membrane potential and cellular content of caspase 3. In addition, intracellular release of reactive oxygen species (ROS) was enhanced by ICA-phytosomes. In conclusion, phytosome formulation of ICA significantly potentiates its cytotoxic activities against OVCAR-3 cells. This is mediated, at least partly, by enhanced ICA cellular permeation, apoptosis, and ROS.

show abstract

Section: Introductionmentioning

confidence: 99%

“…Traditionally, it has been used for erectile dysfunction in ancient Chinese medicine [4]. ICA is therapeutically effective in cases of atherosclerosis, as well as neurodegenerative disorders [3,5,6]. It demonstrates neuroprotective potential and was found to enhance memory in a model of Alzheimer's disease (AD) in mice.…”

Section: Introductionmentioning

confidence: 99%

RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

et al. 2020

View full text Add to dashboard Cite

show abstract

“…It can prevent and/or treat AD by reducing the level of Aβ, and inhibiting the hyperphosphorylation of tau and other mechanisms. [11]To sum up, one phenomenon that emerge from these ndings is except for stigmasterol is derived from Coicis Semen, the rest of active compounds of the top 8 are all from Epimedium. Therefore, we conjecture that Epimedium plays a major role in the treatment of AD, and Coicis Semen plays the role of auxiliary e ciency.…”

Section: Active Ingredientsmentioning

confidence: 99%

“…In addition, Icariin is a major active compound of Epimrdii Herba, which has a neuroprotective effect in the treatment of AD. [11,26] It is also one of the important compounds.…”

Section: Screening Of Active Ingredientsmentioning

confidence: 99%

“…It has been reported that Epimrdii Herba can improve the function of the nervous system in AD treatment. [11]However, few studies have been done on Epimrdii Herba-Coicis Semen (EH-CS) in the treatment of AD and people lack a comprehensive understanding of its mechanism of action. In this study, we used a network pharmacological method to predict and analyze the EH-CS.…”

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

A network pharmacology approach to explore the mechanisms of action of Epimrdii Herba-Coicis Semen for treatment of Alzheimer's disease

Zhou¹

2020

Preprint

View full text Add to dashboard Cite

Background: Traditional Chinese medicine (TCM) can treat diseases through its “multi-component, multi-target, multi-pathway” mechanisms. Especially have advantages in the treatment of diseases with complicated pathogenesis, such as Alzheimer’s disease (AD). Tonifying the kidney and strengthening the spleen is one of the common methods of Chinese Medicine to treat AD. The TCM combination of Epimrdii Herba and Coicis Semen can be used as the main drugs of a prescription for tonifying the kidney and strengthening the spleen. However, the mechanisms for Epimrdii Herba-Coicis Semen (EH-CS) to treat AD is vague. The purpose of this study was to explore the mechanisms of EH-CS on AD using a network pharmacological method.Methods: We retrieved the chemical compounds and targets of Epimrdii Herba-Coicis Semen from the Traditional Chinese Medicine Systems Pharmacology Database and Analysis Platform (TCMSP). We screened the active ingredients based on the pharmacokinetic parameters (ADME). The Human Gene Database (GeenCards) was used to obtain disease targets of Alzheimer’s disease. Then we drew a venn diagram to obtain common targets of Chinese medicine and disease. Based on the topological properties, we screened the key targets. The protein-protein interaction (PPI) network was constructed using the STRING database, and the "Traditional Chinese Medicine-active ingredient-target" network was constructed using Cytoscape software. The key targets were respectively uploaded to the Metascape and DAVID database for GO and KEGG pathway analysis.Results: We obtained 31 active compounds for EH-CS. Flavonoids play important roles in the treatment of AD. A total of 29 key targets, including AKT1, MAPK1, and TP53, etc. The biological processes involve response to lipopolysaccharide, neuron death, neuroinflammatory response, etc. The main pathways include TNF signaling pathways, MAPK signaling pathways, PI3K-Akt signaling pathways and other signaling pathways.Conclusion: The network pharmacology method is an effective tool for exploring the mechanisms of TCM. Based on network pharmacology, this study systematically explained the potential mechanisms of EH-CS on AD. It provides a valuable reference for the development of AD drugs.

show abstract

Icariin Ameliorates Spermatogenesis Disorder in Obese Mice Induced by High‐Fat Diet through Regulating the Glycolytic Pathway

Luo

Zhuge

et al. 2023

Molecular Nutrition Food Res

View full text Add to dashboard Cite

Scope Obesity is a global threat for male infertility, which can cause spermatogenic dysfunction. However, there are no available drugs for the treatment of obesity‐induced spermatogenesis dysfunction. This study characterizes the protective effects of icariin (ICA) on spermatogenesis dysfunction in obese mice. Methods and results Obese mice are induced by a high‐fat diet to determine whether ICA has a protective effect. ICA treatment reduces body weight and the proportion of abnormal sperm, brings about a recovery of sperm count, and the number of spermatogenic cells. ICA treatment improves histopathological changes of the testes and inhibits testicular apoptosis, as evidenced by reduced the expression of Bax and increased the expression of Bcl‐2, PCNA, WT1, GATA‐4, vimentin, HK2, PKM2, and LDHA in the testes. In vitro, TM4 cells are treated with 0.4 mm palmitic acid (PA) to induce Sertoli cell injury, and are then utilized for ICA treatment. ICA improves PA‐induced decreased TM4 cells viability, reduces the levels of lactate, and increases the levels of pyruvate and the expression of HK2, PKM2, and LDHA and restores the glycolytic process in vitro. Conclusion ICA ameliorates spermatogenic dysfunction in obese mice by regulating glycolytic activity, providing effective strategies for obesity treatment.

show abstract

An outline for the pharmacological effect of icariin in the nervous system

Cited by 88 publications

References 147 publications

RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

RETRACTED: Optimized Icariin Phytosomes Exhibit Enhanced Cytotoxicity and Apoptosis-Inducing Activities in Ovarian Cancer Cells

A network pharmacology approach to explore the mechanisms of action of Epimrdii Herba-Coicis Semen for treatment of Alzheimer's disease

Icariin Ameliorates Spermatogenesis Disorder in Obese Mice Induced by High‐Fat Diet through Regulating the Glycolytic Pathway

Contact Info

Product

Resources

About