An Outcome Analysis of Fibrin Sealant versus Staples for Fixation of Split-Thickness Skin Grafts

Shuchi, Akshara; Gupta, Deepti; Sarabahi, Sujata

doi:10.1055/s-0043-1777867

Cited by 1 publication

(1 citation statement)

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“…They are currently used to fix skin grafts (for example, on burn wounds) and to facilitate flap adhesion to the receiving site after extensive surgical dissections. Their composition allows for immediate use without the need for preventive treatments [19,20].…”

Section: Introductionmentioning

confidence: 99%

Nerve Regeneration after a Nerve Graft in a Rat Model: The Effectiveness of Fibrin Glue

Zabbia,

Toia,

Coppola

et al. 2024

JPM

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Background: Simulating the post-traumatic continuity defect of small human peripheral nerves, we compared the effectiveness of fibrin glue with neurorrhaphy for nerve gap restoration. Methods: In twenty-four male Wistar rats, a fifteen mm defect in one sciatic nerve only was made and immediately repaired with an inverted polarity autograft. According to the used technique, rats were divided into Group A (Control), using traditional neurorrhaphy, and Group B (Study), using fibrine glue sealing; in total, 50% of rats were sacrificed at 16 weeks and 50% at 21 weeks. Before sacrifice, an assessment of motor function was done through Walking Track Analysis and an electroneurophysiological evaluation. After sacrifice, selected muscle mass indexes and the histology of the regenerated nerves were assessed. All data were evaluated by Student’s t test for unpaired data. Results: No significant differences were found between the two groups, with only the exception of a relative improvement in the tibialis anterior muscle’s number of motor units in the study group. Conclusion: Despite the fact that the use of fibrin glue as a nerve sealant is not superior in terms of functional recovery, its effectiveness is comparable to that of microsurgical repair. Hence, the faster and technically easier glueing technique could deserve broader clinical application.

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Section: Introductionmentioning

confidence: 99%