An outbreak of West Nile fever among migrants in Kisangani, Democratic Republic of Congo.

Nur, Y.; Groen, Jan; Heuvelmans, Hans; Tuynman, Welmoet; Copra, Cedrick; Osterhaus, Albert D. M. E.

doi:10.4269/ajtmh.1999.61.885

Cited by 54 publications

(37 citation statements)

References 14 publications

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“…In samples collected 24-48 hr after the onset of symptoms, 70.6% were negative, which was a close figure to the 75% previously reported by Hasebe et al [2002]. Chikungunya viruses were isolated mainly from these early sampled sera, different from results reported in Kisangani [Nur et al, 1999]. RT-PCR for the detection of alphavirus species and Chikungunya virus have been developed by others [Pfeffer et al, 1997;Powers et al, 2000;Hasebe et al, 2002].…”

Section: Discussionmentioning

confidence: 53%

“…During the last 39 years, there has been no further report on Chikungunya virus isolation in the Democratic Republic of the Congo. However in February 1998, IgM antibodies against Chikungunya virus were found in 12 patients during an outbreak of West Nile fever among migrants in Kisangani (Democratic Republic of the Congo) [Nur et al, 1999]. In 1999 and 2000, two important outbreaks of febrile illness were reported following heavy rain falls in the Matete and Kingabwa quarters of the capital city Kinshasa (Democratic Republic of the Congo).…”

Section: Introductionmentioning

confidence: 99%

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Epidemic resurgence of Chikungunya virus in democratic Republic of the Congo: Identification of a new central African strain

Pastorino

Muyembe-Tamfum

Bessaud

et al. 2004

Journal of Medical Virology

180

139

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The resurgence of Chikungunya virus is described during an urban epidemic in Kinshasa Democratic Republic of the Congo, after 39 years without any isolation of the virus. Chikungunya virus was isolated in sera from nine patients with clinical symptoms. A 1,200 bp long partial sequence of the E1/3'UTR genomic region was determined for each isolate. All sequences clustered in the central African lineage. They constitute Chikungunya virus reference sequences for the Democratic Republic of the Congo.

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Section: Discussionmentioning

confidence: 53%

Section: Introductionmentioning

confidence: 99%

Epidemic resurgence of Chikungunya virus in democratic Republic of the Congo: Identification of a new central African strain

Pastorino

Muyembe-Tamfum

Bessaud

et al. 2004

Journal of Medical Virology

180

139

View full text Add to dashboard Cite

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“…Since the discovery of the first isolate of WNV in Uganda in 1937, few outbreaks of West Nile disease were reported between 1988 and 2003 in African countries such as the Sudan (8,24), the Democratic Republic of Congo (19), and Tunisia (1,9), but to our knowledge none occurred in West Africa. Few viral isolates in humans, mosquitoes, and domestic animals were reported in 1958-1998 from Kenya, WANG ET AL.…”

Section: Discussionmentioning

confidence: 97%

Seroprevalence of West Nile Virus in Ghana

Wang

Sarkodie²,

Danso³

et al. 2009

Viral Immunology

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The epidemiology of West Nile virus (WNV) in Ghana, sub-Saharan Africa, and its relevance to transfusion were newly assessed. A total of 1324 plasma samples from five Ghanaian populations, including 529 children (<6 y old, pre-transfusion) and 795 adults (236 blood donors, 226 HIV-infected or non-infected pregnant women, 203 HIV symptomatic patients, and 130 AIDS patients) were screened for WNV RNA. No WNV RNA was detected, but 4.8% (13/271) and 27.9% (127/455) carried specific IgG in children and adults, respectively, and 2.4% (4/167) of the children had IgM. The prevalence of IgG antibody to WNV increased progressively and peaked around 30% between ages 1 and 30 y, then stabilized. The absence of viremia in four WNV IgM-positive children, and of reactivation in HIV-infected patients suggests that once host immunity is established, it appears to be robust. In addition, there were no clinical reports of WNV infection in the hospital in Kumasi, Ghana, suggesting that WNV epidemiology in Ghana differs from that seen in the U.S. Most infections occur early in life, and as the window for infection is quite short, the risk of transmission by transfusion appears to be low, and the risk of pathogenicity in immunocompetent recipients appears to be limited in an endemic area such as Ghana.

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“…Studies conducted in several sub-Saharan countries have reported a quite variable seroprevalence in humans [120,[163][164][165] , with few documented clinical cases, but these data should be taken carefully since most studies have not addressed possible cross-reactivity with other circulating flaviviruses, and clinical cases may have been attributed to other diseases that present similar symptoms. Serological evidence of WNV infection has also been described in horses in the continent [165] .…”

Section: Africa Asia and Oceaniamentioning

confidence: 99%