Article HistoryHorses are companion animals that are reared for multipurpose such as riding, racing, plowing, pulling carts, etc. Therefore, the population of horses is increasing in Punjab. Horses are very sensitive to internal parasites and may frequently be prone to infection caused by small strongyles. Nematodes are responsible for poor health, reduced growth, weight loss, anorexia, diarrhea, gestational lesions, liver damage, and a high mortality rate. The management strategies practiced by the farm owners have an impact on the prevalence of parasitic infections in animals. Farmers adopt different management practices for the well-being of horses. Anthelmintic drugs are the primary control method for their prevention. The drugs used for parasite control give varying efficacy. Therefore, a study was planned to conduct a questionnaire-based survey in Punjab to estimate the stud farmer's practices for parasite control and to check the efficacy of 6 brands of drugs commercially available in Punjab. The data of the questionnaire was recorded on Google Forms and fecal samples were also collected from various stud farms for egg hatch assay. Based on the survey, Systamax ® was the most widely accepted brand of anthelmintic by farmers for the treatment of helminth infections in horses (82.98%). In the egg hatch assay, it is estimated that Parazole ® had the lowest dose (0.2 mg/mL) at which 50% inhibition of cyathostomins egg hatching occurred. While Oxafax ® showed the highest dose (2.4 mg/mL) at which 50% inhibition of egg hatching occurred. In vitro, the efficacy of Oxafax ® was less as compared to other brands. However, the dose-response of all six brands had a non-significant difference. It is concluded that the different strategies adopted by horse owners had a role in the prevalence of parasitic infections in horses and all six brands had varying efficacy against small nematodes.