An Outbreak of Severe Respiratory Tract Infection Due to Human Metapneumovirus in a Long-Term Care Facility

Boivin, Guy; Serres, Gaston De; Hamelin, Marie‐Ève; Côté, Stéphanie; Argouin, Marco; Tremblay, Geneviève; Maranda-Aubut, Renée; Sauvageau, Chantal; Ouakki, Manale; Boulianne, Nicole; Couture, Christian

doi:10.1086/513204

Cited by 179 publications

(174 citation statements)

References 28 publications

Supporting

Mentioning

167

Contrasting

Unclassified

Order By: Relevance

“…19 Frequently, risk population, including young children and the elderly, infected with hMPV require hospitalization. 20 Moreover, mortality as a result of hMPV can reach up to 10% in the elderly. 3,20 Recurrent infections with hRSV or hMPV are common in children 21,22 and adults.…”

Section: Introductionmentioning

confidence: 99%

Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection

et al. 2016

View full text Add to dashboard Cite

Human Respiratory syncytial virus (hRSV) and human metapneumovirus (hMPV) are the two major etiological viral agents of lower respiratory tract diseases, affecting mainly infants, young children and the elderly. Although the infection of both viruses trigger an antiviral immune response that mediate viral clearance and disease resolution in immunocompetent individuals, the promotion of long-term immunity appears to be deficient and reinfection are common throughout life. A possible explanation for this phenomenon is that hRSV and hMPV, can induce aberrant T cell responses, which leads to exacerbated lung inflammation and poor T and B cell memory immunity. The modulation of immune response exerted by both viruses include different strategies such as, impairment of immunological synapse mediated by viral proteins or soluble factors, and the induction of pro-inflammatory cytokines by epithelial cells, among others. All these viral strategies contribute to the alteration of the adaptive immunity in order to increase the susceptibility to reinfections.In this review, we discuss current research related to the mechanisms underlying the impairment of T and B cell immune responses induced by hRSV and hMPV infection. In addition, we described the role each virulence factor involved in immune modulation caused by these viruses.

show abstract

Section: Introductionmentioning

confidence: 99%

Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection

et al. 2016

View full text Add to dashboard Cite

show abstract

“…[2][3][4][5] Infection with HMPV has been associated with an estimated 20 000 U.S. hospitalizations annually among children aged <5 years. 6 However, the infrequent testing and low index of suspicion associated with HMPV may have limited the assessment of temporal trends in HMPV circulation.…”

mentioning

confidence: 99%

“…Also, many studies have demonstrated that HMPV causes a respiratory tract infection clinically indistinguishable from infections caused by respiratory syncytial virus (RSV) and influenza. [1][2][3][4][5] In contrast, the specific prevention options and some populations severely affected vary for HMPV, RSV, and influenza. 7 Currently there is no vaccine for HMPV.…”

mentioning

confidence: 99%

Human Metapneumovirus Circulation in the United States, 2008 to 2014

Haynes¹,

Fowlkes

Schneider³

et al. 2016

Pediatrics

View full text Add to dashboard Cite

show abstract

“…Almost all people acquire seropositivity for hMPV by the age of 10 years, 2 and hMPV is known to infect individuals repeatedly throughout adult life and into old age. [5][6][7][8][9] Although there are no reports of IgG titer differences between patients with hypertension and normotensive controls after individual infections with pathogens, including hMPV, it is possible that hypertension itself may increase the anti-IgG titer in response to repeated hMPV infections in the elderly. In this present cross-sectional study, however, we could not show any time-course data for anti-hMPV-IgG titers in individual subjects.…”

Section: Discussionmentioning

confidence: 99%

“…4 In January 2005, we reported an outbreak of nosocomial hMPV infection in elderly subjects in a long-term care facility (LTCF) in Japan. 5 Several subsequent reports revealed that hMPV infection outbreaks frequently occur in LTCFs, 6 not only in the winter 5,6 but also in summer, 7 with high mortality. Serological responses to hMPV-induced respiratory tract illnesses were frequently found (12.8%) among common viruses during a 52-week intervention period in residents of an LTCF.…”

Section: Introductionmentioning

confidence: 99%

Association between human metapneumovirus seroprevalence and hypertension in elderly subjects in a long-term care facility

et al. 2011

View full text Add to dashboard Cite

Recently, relations between hypertension and infections caused by several pathogens have been reported. However, few studies have examined the relationship between human metapneumovirus (hMPV) and hypertension in elderly inpatients. To assess the association between anti-hMPV-immunoglobulin G (IgG) titer and the prevalence of hypertension, we conducted a case-control study in a Japanese long-term care facility (LTCF). The participants included 84 hypertensive patients aged X65 years, and 84 age-and sex-matched normotensive controls (38 males and 46 females in each group; cases, 79.9 ± 8.4 (s.d.) years; controls, 80.1 ± 8.3 years). Data on underling chronic clinical conditions were collected. Titers were measured using an immunofluorescence assay kit. The significance of risk factor differences was analyzed using univariate and multivariate comparisons of cases and controls. All serum samples were positive for hMPV, and IgG titers ranged from 40-fold to more than 5120-fold. There were no significant sex-or age-related differences in log 2 (anti-hMPV-IgG titer/10) among the subjects. Compared with normotensive subjects, hypertensive patients presented significantly higher log 2 (anti-hMPV-IgG titer/10) values (Po0.001). After adjustment with multiple logistic analysis, the odds ratio for log 2 (anti-hMPV-IgG titer/10) was 1.42 (95% confidence interval 1.16-1.75, P¼0.001) relative to normotensive subjects. In all subjects, stepwise multiple regression analysis revealed that both hypertension and a poor nutritional state independently contributed to increased log 2 (anti-hMPV-IgG titer/10). These observations suggest that an increased anti-hMPV-IgG titer was closely related to hypertension in elderly subjects in a Japanese LTCF.

show abstract

An Outbreak of Severe Respiratory Tract Infection Due to Human Metapneumovirus in a Long-Term Care Facility

Abstract: hMPV can be associated with important outbreaks of acute respiratory tract infection in elderly institutionalized persons.

Cited by 179 publications

References 28 publications

Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection

Aberrant T cell immunity triggered by human Respiratory Syncytial Virus and human Metapneumovirus infection

Human Metapneumovirus Circulation in the United States, 2008 to 2014

Association between human metapneumovirus seroprevalence and hypertension in elderly subjects in a long-term care facility

Contact Info

Product

Resources

About