An Outbreak of Serratia marcescens Infections Related to Contaminated Chlorhexidine

Vigeant, Patrice; Loo, Vivian G.; Bertrand, Céline; Dixon, Catherine; Hollis, Richard J.; Pfaller, Michael A.; McLean, A. Peter H.; Briedis, Dalius J.; Perl, Trish M.; Robson, Hugh G.

doi:10.2307/30141429

Cited by 64 publications

(40 citation statements)

References 6 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…2,3,6,10 This is the first reported outbreak in a BMT and oncology unit. A feature of the outbreak was prolonged patient carriage, which frequently led to invasive infection during neutropenic episodes.…”

Section: Discussionmentioning

confidence: 99%

An outbreak of multiply resistant Serratia marcescens: the importance of persistent carriage

Knowles

Herra

Devitt

et al. 2000

Bone Marrow Transplant

View full text Add to dashboard Cite

Summary:An outbreak of multi-resistant Serratia marcescens involving 24 patients occurred in a bone marrow transplant and oncology unit, from September 1998 to June 1999, of whom 14 developed serious infection. This is the first such outbreak described in a BMT unit. All isolates demonstrated the same antimicrobial susceptibility pattern and were the same unusual serotype O21:K14. The antimicrobial susceptibility profile showed reduced susceptibility to ciprofloxacin, gentamicin and piperacillin-tazobactam. As the latter two antimicrobials are part of our empiric therapy for febrile neutropenia, they were substituted with meropenem and amikacin during the outbreak. Investigation revealed breaches in infection control practices. Subsequently, the outbreak was contained following implementation of strict infection control measures. A prominent feature of the outbreak was prolonged carriage in some patients. These patients may have acted as reservoirs for cross-infection. This report also indicates that patients who become colonised with Serratia marcescens may subsequently develop invasive infection during neutropenic periods. Bone Marrow Transplantation (2000) sistence of Serratia marcescens in the environment and prolonged patient carriage, factors which undoubtedly contributed to the length of the outbreak. Furthermore, patients who were carriers frequently developed invasive infection during periods of neutropenia. Materials and methods Patient dataFrom September 1998 to June 1999, we observed an outbreak of Serratia marcescens involving 24 patients, in a 31-bed haematology-oncology unit, which incorporates the National Bone Marrow Transplant unit. The unit has four six-bedded wards, three single rooms and four HEPAfiltered BMT rooms. Fifteen patients were haematology patients, six of whom were receiving cytotoxic chemotherapy, eight were post BMT and one patient, the index case, was on cytotoxic chemotherapy during his first two episodes of sepsis and in the early post-BMT phase for his third. Nine patients were oncology patients, all of whom were receiving cytotoxic chemotherapy for their underlying disease. An infected case was defined as a patient with symptoms and/or signs of infection and Serratia marcescens was cultured from an infected site. A colonised case was defined as a patient in whom Serratia marcescens was cultured in the absence of symptoms and/or signs of infection. The number of new cases per month is shown in Figure

show abstract

Section: Discussionmentioning

confidence: 99%

An outbreak of multiply resistant Serratia marcescens: the importance of persistent carriage

Knowles

Herra

Devitt

et al. 2000

Bone Marrow Transplant

View full text Add to dashboard Cite

show abstract

“…The main references consulted on antiseptic contamination appoint issues of handling and inadequate care that lead to product instability and allow microorganisms to grow (3)(4)(5)(6) .…”

Section: Discussionmentioning

confidence: 99%

Microbiological evaluation of different antiseptic povidone-iodine and chlorhexidine formulations after intentional contamination of containers

Padovani¹,

Graziano

Goveia³

2008

Rev. Latino-Am. Enfermagem

View full text Add to dashboard Cite

show abstract

“…Es weist Wirkungslücken im Gramnegativen Bereich auf [213,214], was bei Kontamination der Lösung nosokomiale Epidemien zur Folge haben kann [215]. Es hat zytotoxische und im Tierversuch mutagene Eigenschaften [207].…”

Section: Hautantiseptikunclassified

Empfehlung zur Prävention nosokomialer Infektionen bei neonatologischen Intensivpflegepatienten mit einem Geburtsgewicht unter 1500 g

2007

Bundesgesundheitsbl.

View full text Add to dashboard Cite

Abkürzungsverzeichnis BAL Publizierte Daten aus Surveillance-SystemenJede Infektion, die sich erstmals mehr als 72 Stunden nach der Geburt manifestiert, wird als "nosokomiale Infektion" (NI) bezeichnet [1, 21, 32, 33]. Diese Infektionen werden auch als "Late-onset"-Infektionen bezeichnet ("Late-onset-Sepsis") [18, 19, 20, 34]. Eine Auswahl der bislang publizierten Studien mit Angaben zum Spektrum der NI zeigt . Tabelle 1 [35]. (46 von 88 FG) P < 0,0001) und 24,2% bei GG < 1500 g (vs. 12,7% ≥1500g; P < 0,0001). NEO-KISS

show abstract

An Outbreak of Serratia marcescens Infections Related to Contaminated Chlorhexidine

Cited by 64 publications

References 6 publications

An outbreak of multiply resistant Serratia marcescens: the importance of persistent carriage

An outbreak of multiply resistant Serratia marcescens: the importance of persistent carriage

Microbiological evaluation of different antiseptic povidone-iodine and chlorhexidine formulations after intentional contamination of containers

Empfehlung zur Prävention nosokomialer Infektionen bei neonatologischen Intensivpflegepatienten mit einem Geburtsgewicht unter 1500 g

Contact Info

Product

Resources

About