An Outbreak of Mayaro Virus Disease in Belterra, Brazil

LeDuc, James W.; Pinheiro, F. P.; Rosa, A.P.A. Travassos da

doi:10.4269/ajtmh.1981.30.682

Cited by 74 publications

(55 citation statements)

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“…[2][3][4][5][6][7][8][9] MAYV causes a self-limited illness characterized by fever, rash, and severe arthralgia, which is similar to chikungunya virus and other members of the Semliki Forest antigenic complex. 10 Outbreaks of Mayaro fever recognized to date have been small and associated with rural communities, 1,11,12 likely reflecting spillover infections from a sylvatic (enzootic) transmission cycle of MAYV. Because of limited surveillance and diagnostic laboratory facilities in much of the endemic region, many Mayaro fever cases are doubtlessly undiagnosed, leading to a significant underrecognition of disease.…”

Section: Introductionmentioning

confidence: 99%

Experimental Transmission of Mayaro Virus by Aedes aegypti

Long

Ziegler

Thangamani³

et al. 2011

The American Society of Tropical Medicine and Hygiene

196

209

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Abstract. Outbreaks of Mayaro fever have been associated with a sylvatic cycle of Mayaro virus (MAYV) transmission in South America. To evaluate the potential for a common urban mosquito to transmit MAYV, laboratory vector competence studies were performed with Aedes aegypti from Iquitos, Peru. Oral infection in Ae. aegypti ranged from 0% (0/31) to 84% (31/37), with blood meal virus titers between 3.4 log 10 and 7.3 log 10 plaque-forming units (PFU)/mL. Transmission of MAYV by 70% (21/30) of infected mosquitoes was shown by saliva collection and exposure to suckling mice. Amount of viral RNA in febrile humans, determined by real-time polymerase chain reaction, ranged from 2.7 to 5.3 log 10 PFU equivalents/mL. Oral susceptibility of Ae. aegypti to MAYV at titers encountered in viremic humans may limit opportunities to initiate an urban cycle; however, transmission of MAYV by Ae. aegypti shows the vector competence of this species and suggests potential for urban transmission.

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Section: Introductionmentioning

confidence: 99%

Experimental Transmission of Mayaro Virus by Aedes aegypti

Long

Ziegler

Thangamani³

et al. 2011

The American Society of Tropical Medicine and Hygiene

196

209

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“…In some cases, the rash occurs widely, but in most patients, it is more intensely observed on the chest, back, arms and legs. The rash usually appears on the fifth day of disease and persists for three days [51,60,61].…”

Section: /11mentioning

confidence: 99%

“…However, the arthralgia symptom can persist over many months causing a disabling polyarthritis that, in some cases, can be associated with additional incidences of fever [16,36,61]. There are reports of chronic and recurrent arthralgia for up to 6 months after a MAYV infection.…”

Section: /11mentioning

confidence: 99%

Mayaro Virus Disease

De-Simone¹

2014

JHVRV

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Mayaro virus produces a nonspecific, sublethal disease in man with symptoms that are often confused with dengue. The symptoms of arthralgia, often associated with these viral infections, can cause an incapacitating disability. To date, outbreaks have been localized and sporadic within the Pan-Amazonia forest since its first isolation in 1954 (Trinidad and Tobago). The available literature is diverse, scarce and dispersed. Mayaro virus is an alphavirus, which is phylogenetically related to the Semliki forest antigenic complex. In the New World, Mayaro and the related UNA viruses are the only members of this complex that have been isolated. The genome of Mayaro consists of single-stranded RNA with a positive charge and a length of 12 kb that can be subdivided into genomic and subgenomic regions that encode nonstructural and structural proteins, respectively. Mayaro has shown great plasticity in hosts for vertebrate infections, but high specificity in invertebrates towards the family Culicidae (mosquitoes). Risk factors for infection are forested areas in northern South America and the rainy season. Two genotypes of MAYV have been identified, L (restricted to Belterra, Brazil) and D (widely distributed in the Pan-Amazonia). The enzootic cycle is similar to the jungle cycle of yellow fever, which involves Haemagogus mosquitoes and monkeys as reservoirs. Of concern is the potential spread of the virus by the involvement of other secondary vectors and hosts such as Aedes aegypti, Aedes albopictus and Aedes scapularis that have been shown experimentally to efficiently transmit the virus. Together with the observed high viremia levels of infected individuals, a significant risk exists for an emerging disease in urban, rural and peridomestic locations close to enzootic foci of Mayaro virus.

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“…Four of these 11 subjects (36%) reported having had an acute febrile episode during the preceding 2 months. 56 Thus, in the subsequent study, the prevalence of MAYV exposure rose to 30% in the autochthonous population. One observation of this study, which is similar to the findings of the 1954 study in Trinidad and Tobago, 24 is the strong association of MAYV and yellow fever virus.…”

Section: Seroprevalence Of Antibodies Against Mayvmentioning

confidence: 99%

“…Seventyone (22%) were found to have MAYV antibodies. 56 During the Belterra outbreak, five fatal cases and one non-fatal case of yellow fever were reported between January and April 1978. In the parallel seroepidemiological survey, 11 people (3.3%) had antibodies against yellow fever.…”

Section: Seroprevalence Of Antibodies Against Mayvmentioning

confidence: 99%

Mayaro virus: the jungle flu

Izurieta¹,

DeLacure²,

Izurieta³

et al. 2018

VAAT

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Abstract:Mayaro fever is an emerging acute viral disease endemic in Central and South America. Mayaro virus (MAYV) is classified in the Semliki Forest virus antigenic complex and shares similarities with the alphavirus Chikungunya virus and the flavivirus Dengue virus. MAYV is an arbovirus transmitted by Haemagogus janthinomys, with competence also demonstrated in Aedes aegypti, Aedes scapularis, and Anopheles quadrimaculatus. Outbreaks and small epidemics of Mayaro fever have occurred in several countries in northern South America and the Caribbean. In addition, travel-associated cases have been reported in European nationals returning from endemic areas. Clinical features of Mayaro fever include fever, chills, persistent arthralgia, retro-orbital pain, maculopapular rash, itching, dizziness, and, rarely, lymphadenopathy. Methods of control for MAYV are similar to those used for other sylvatic arboviruses. Although MAYV was discovered as long ago as the 1950s and continues to be prevalent in the tropical areas of the Americas, it remains neglected and under-studied. This paper provides a thorough and current review of the published MAYV literature ranging from its original description to modern outbreaks, and from the basic virus characteristics to the clinical and epidemiological aspects of this disease.

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An Outbreak of Mayaro Virus Disease in Belterra, Brazil

Cited by 74 publications

References 0 publications

Experimental Transmission of Mayaro Virus by Aedes aegypti

Experimental Transmission of Mayaro Virus by Aedes aegypti

Mayaro Virus Disease

Mayaro virus: the jungle flu

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