An outbreak of livestock-associated meticillin-resistant Staphylococcus aureus (LA-MRSA) clonal complex 398 in a regional burns centre

Stone, Matthew James; Swales, Claire; Bond, Stuart; Muthayya, Preetha; Sarma, Jogesh

doi:10.1016/j.jhin.2021.12.005

Cited by 5 publications

(2 citation statements)

References 33 publications

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“…[ 133 ] reported that approximately 13% of LA-MRSA-positive patients who could not be typed by pulsed-field gel electrophoresis (PFGE) had an active infection compared with 42% of patients with LA-MRSA who could be typed by PFGE, which was less virulent than LA-MRSA. This is consistent with the fact that several virulence determinants have been identified among LA-MRSA CC398 [ 65 , 129 , 136 – 144 ]. However, it is necessary to continuously monitor the determinants and epidemiology of their virulence because several LA-MRSA CC398 isolates have been reported with important human virulence factors, including staphylococcal enterotoxins [ 65 , 139 ] and bicomponent Panton-Valentine leukocidin [ 129 , 137 , 138 , 141 , 142 ].…”

Section: Pig–pig Transmissionsupporting

confidence: 88%

A review of new emerging livestock-associated methicillin-resistant Staphylococcus aureus from pig farms

et al. 2023

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Methicillin-resistant Staphylococcus aureus (MRSA) is a S. aureus strain resistant to β-lactam antibiotics and is often associated with livestock, known as livestock-associated (LA)-MRSA. Using molecular typing with multi-locus sequence typing, MRSA clones have been classified in pigs, including clonal complex 398. Livestock-associated-methicillin-resistant S. aureus was first discovered in pigs in the Netherlands in 2005. Since then, it has been widely detected in pigs in other countries. Livestock-associated-methicillin-resistant S. aureus can be transmitted from pigs to pigs, pigs to humans (zoonosis), and humans to humans. This transmission is enabled by several risk factors involved in the pig trade, including the use of antibiotics and zinc, the size and type of the herd, and the pig pen management system. Although LA-MRSA has little impact on the pigs' health, it can be transmitted from pig to pig or from pig to human. This is a serious concern as people in direct contact with pigs are highly predisposed to acquiring LA-MRSA infection. The measures to control LA-MRSA spread in pig farms include conducting periodic LA-MRSA screening tests on pigs and avoiding certain antibiotics in pigs. This study aimed to review the emerging LA-MRSA strains in pig farms.

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Section: Pig–pig Transmissionsupporting

confidence: 88%

A review of new emerging livestock-associated methicillin-resistant Staphylococcus aureus from pig farms

et al. 2023

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“…In recent years, numerous MRSA strains have been isolated from different animal species, especially pigs, in many countries and were called livestock-associated MRSA (LA-MRSA) [ 11 , 12 , 13 ]. However, in most cases, MRSA colonized the animal host asymptomatically [ 14 ]. Most LA-MRSA belong to the genetic lineage clonal complex (CC) 398.…”

Section: Introductionmentioning

confidence: 99%

MRSA in Humans, Pets and Livestock in Portugal: Where We Came from and Where We Are Going

et al. 2022

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Over the years, molecular typing of methicillin-resistant S. aureus (MRSA) has allowed for the identification of endemic MRSA strains and pathogenic strains. After reaching a peak of predominance in a given geographic region, MRSA strains are usually replaced by a new strain. This process is called clonal replacement and is observed worldwide. The worldwide spread of hospital-associated MRSA (HA-MRSA), community-associated MRSA (CA-MRSA) and livestock-associated MRSA (LA-MRSA) clones over the last few decades has allowed this microorganism to be currently considered a pandemic. In Portugal, most HA-MRSA infections are associated with EMRSA-15 (S22-IV), New York/Japan (ST5-II) and Iberian (ST247-I) clones. Regarding the strains found in the community, many of them are frequently associated with the hospital environment, namely the Pediatric, Brazilian and Iberian clones. On the other hand, a strain that is typically found in animals, MRSA clonal complex (CC) 398, has been described in humans as colonizing and causing infections. The ST398 clone is found across all animal species, particularly in farm animals where the economic impact of LA-MRSA infections can have disastrous consequences for industries. In contrast, the EMRSA-15 clone seems to be more related to companion animals. The objective of this review is to better understand the MRSA epidemiology because it is, undoubtedly, an important public health concern that requires more attention, in order to achieve an effective response in all sectors.

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Energy and economic analysis of energy efficiency actions in surgery rooms: A dynamic analysis

Cappiello

2024

Applied Energy

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An outbreak of livestock-associated meticillin-resistant Staphylococcus aureus (LA-MRSA) clonal complex 398 in a regional burns centre

Cited by 5 publications

References 33 publications

A review of new emerging livestock-associated methicillin-resistant Staphylococcus aureus from pig farms

A review of new emerging livestock-associated methicillin-resistant Staphylococcus aureus from pig farms

MRSA in Humans, Pets and Livestock in Portugal: Where We Came from and Where We Are Going

Energy and economic analysis of energy efficiency actions in surgery rooms: A dynamic analysis

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