An outbreak of listerial myelitis in sheep

Seaman, J. T.; Carrigan, M. J.; Cockram, F. A.; Carter, G. I.

doi:10.1111/j.1751-0813.1990.tb07733.x

Cited by 18 publications

(11 citation statements)

References 3 publications

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“…The postmortem examination revealed that necrotic foci in congested liver, highly congested kidney, cloudiness of the cerebrospinal fluid, thickened and congested meninges, congested brain and congestion of blood vessels of brain stem and cerebellum (Fig. 5) and the obtained results were in agreement with that obtained by (Seaman et al, 1990;El-Sawalhy et al, 1999). These results disagreed with that observed by (Al-Dughaym et al, 2001) who observed that the postmortem picture of listeriosis of sheep was bilateral keratoconjunctivitis, lung showed multiple areas of hemorrhage, marked congestion and turbid and edematous meninges.…”

Section: Resultssupporting

confidence: 90%

Epidemiological studies on Listeriosis in sheep

Younis

Elsawalhy

Soumaya³

et al. 2010

Journal of Veterinary Medical Research

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This study was carried out in El-Dakahilia governorate on six flocks at different areas 2448 sheep located with varied ages and with history of nervous manifestation. The Prevalence of nervous manifestations was 4.9% (105 /2448). The case fatality rate and mortality rate were 77.14 % and 3.3 % respectively. The percent of Listeria monocytogenes was 26.66% (8/30). Examination of CSF of diseased and control healthy sheep revealed significance elevation of total cell count, total protein and creatinine cytokinase of diseased than control sheep.

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Section: Resultssupporting

confidence: 90%

Epidemiological studies on Listeriosis in sheep

Younis

Elsawalhy

Soumaya³

et al. 2010

Journal of Veterinary Medical Research

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“…In the terminal stage, animals become recumbent and may show convulsions. Rare cases have been described, in which limb paralysis occurred due to affection of the spinal cord alone (myelitis) without involvement of the brain [134, 163, 164]. The course of infection in small ruminants (sheep and goats) is generally acute and animals die within 1–3 days after clinical signs became apparent.…”

Section: Listeriosis In Ruminantsmentioning

confidence: 99%

“…However, the neuropathological pattern of the natural disease and the observation of intraaxonal and intraneuronal bacteria (Figures 5 and 6) strongly suggest that foodborne LM cells invade the brainstem by axonal migration along various cranial nerves [87, 131, 136, 165, 254]. Correspondingly, in an outbreak of listeric myelitis in sheep ascending infection via the sensory nerves following dermatitis was suspected and subcutaneous injection of LM in the lumbar and thoracic regions may cause lumbar and thoracic myelitis in mice [163, 255]. These observations indicate that the site of bacterial invasion determines the topography of CNS lesions.…”

Section: Neuropathogenesismentioning

confidence: 99%

Rhombencephalitis Caused byListeria monocytogenesin Humans and Ruminants: A Zoonosis on the Rise?

Oevermann

Zurbriggen

Vandevelde

2010

Interdisciplinary Perspectives on Infectious Diseases

125

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Listeriosis is an emerging zoonotic infection of humans and ruminants worldwide caused by Listeria monocytogenes (LM). In both host species, CNS disease accounts for the high mortality associated with listeriosis and includes rhombencephalitis, whose neuropathology is strikingly similar in humans and ruminants. This review discusses the current knowledge about listeric encephalitis, and involved host and bacterial factors. There is an urgent need to study the molecular mechanisms of neuropathogenesis, which are poorly understood. Such studies will provide a basis for the development of new therapeutic strategies that aim to prevent LM from invading the brain and spread within the CNS.

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“…1,3,4,7 In ruminants and humans, L. monocytogenes likely reaches the CNS by centripetal axonal migration not only through the trigeminal nerve but also other cranial and spinal nerves, and spreads further rostrally and caudally within the CNS. 1,7,17 In the cat described here, the particular pattern of lesions including the presence of microabscesses in the cervical nerve roots, their maximal severity in the cervical intumescence, and gradual decrease from the spinal cord to the midbrain indicates that the bacterium may have entered the CNS via nerve roots from the brachial plexus. However, the source of infection could not be identified because the cat was a stray cat and no anamnestic information was available.…”

mentioning

confidence: 83%

Encephalomyelitis Resembling Human and Ruminant Rhombencephalitis Caused by Listeria monocytogenes in a Feline Leukemia Virus-Infected Cat

Raith

Müntener

Vandevelde

et al. 2010

Journal of Veterinary Internal Medicine

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A n intact, male, stray cat of unknown age was referred to the small animal clinic, University of Bern, Switzerland, in lateral recumbency. On clinical examination, the cat was in a poor nutritional state and severely dehydrated. Small hemorrhages were observed at the nares and medial canthi of the eyes. Heart rate and temperature were normal. Laboratory evaluation supported the clinical impression of dehydration with high hematocrit, high total protein concentration, and mild azotemia with normal urine specific gravity. Thoracic radiographs were normal.On neurologic examination, the cat had a decreased consciousness and nonambulatory tetraparesis, which was more pronounced in the front limbs. Postural reactions were decreased in the hind limbs and nearly absent in the front limbs. Front limb reflexes were decreased, and hind limb reflexes were increased. Muscle tone was increased in the hind limbs and decreased in the front limbs. Neurological deficits and abnormalities in muscle tone were more pronounced on the right side. There was mild generalized muscle atrophy. Examination of cranial nerves was normal. Palpation of the cervico-thoracic vertebrae elicited pain. Impaired consciousness was interpreted as a neurological sign and not attributed to poor nutritional condition. Neuroanatomical localization was multifocal (ie, intracranial and C6-T2). Because of the small hemorrhages in the nose and eyes, trauma or infectious disease were suspected. An ELISA test a was positive for feline leukemia virus (FeLV) antigen and negative for feline immunodeficiency virus. Despite analgesia and treatment with IV fluids the cat did not improve and therefore was euthanized.Necropsy identified a right-sided focal area of reddishtan discoloration and swelling in the cervical intumescence of the spinal cord (Fig 1). Organ samples and the entire central nervous system (CNS) were fixed in 10% neutral buffered formalin. Representative samples of the CNS and internal organs were embedded in paraffin, sectioned at 5 mm and stained with hematoxylin and eosin. Microscopic examination disclosed an encephalomyelitis restricted to the brainstem and cervicothoracic spinal cord. Lesions were most severe in the cervical intumescence (Figs 1, 2A) and tapered off cranially along the cervical spinal cord and brainstem (Fig 2B) into the midbrain and caudally into the first thoracic spinal cord segments. Lesions consisted of microabscesses, characterized by focal aggregates of neutrophils, macrophages, and microglia with rod-shaped nuclei in gray and white matter associated with prominent perivascular cuffs of lymphocytes, macrophages, and few neutrophils (Fig 2B and C). A few inflammatory infiltrates also were observed in the ventral nerve roots of the cervical intumescence. Additional changes included neuronal degeneration and necrosis, neuronophagia (Fig 2D), vasculitis with perivascular hemorrhages, and mild lympho-histiocytic meningitis. Immunohistochemistry was performed with a polyclonal rabbit antibody against Listeriolysin O (1 : 200) b...

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An outbreak of listerial myelitis in sheep

Cited by 18 publications

References 3 publications

Epidemiological studies on Listeriosis in sheep

Epidemiological studies on Listeriosis in sheep

Rhombencephalitis Caused byListeria monocytogenesin Humans and Ruminants: A Zoonosis on the Rise?

Encephalomyelitis Resembling Human and Ruminant Rhombencephalitis Caused by Listeria monocytogenes in a Feline Leukemia Virus-Infected Cat

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