An outbreak of Kyasanur forest disease in the Wayanad and Malappuram districts of Kerala, India

Sadanandane, C; Ayyanar, Elango; Marja, Noonu; Sasidharan, PK; Raju, K.H.K.; Jambulingam, P.

doi:10.1016/j.ttbdis.2016.09.010

Cited by 37 publications

(33 citation statements)

References 13 publications

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“…In India, human cases with KFDV infection have been continuously reported. Especially in 2014 and 2015, human/monkey deaths associated with KFDV infection were identified (Sadanandane et al 2017 ). Annual numbers of human cases of KFDV are estimated at 400–500 with a fatality rate of 3%–5% (Holbrook 2012 ).…”

Section: Families Unassigned To Any Ordermentioning

confidence: 99%

Tick-Borne Viruses

et al. 2018

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Ticks are important vectors for the transmission of pathogens including viruses. The viruses carried by ticks also known as tick-borne viruses (TBVs), contain a large group of viruses with diverse genetic properties and are concluded in two orders, nine families, and at least 12 genera. Some members of the TBVs are notorious agents causing severe diseases with high mortality rates in humans and livestock, while some others may pose risks to public health that are still unclear to us. Herein, we review the current knowledge of TBVs with emphases on the history of virus isolation and identification, tick vectors, and potential pathogenicity to humans and animals, including assigned species as well as the recently discovered and unassigned species. All these will promote our understanding of the diversity of TBVs, and will facilitate the further investigation of TBVs in association with both ticks and vertebrate hosts.

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Section: Families Unassigned To Any Ordermentioning

confidence: 99%

Tick-Borne Viruses

et al. 2018

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“…OHFV is found in a small region near Novosibirsk in Russia [83], KFDV is found in an ever-expanding range in India [84] and its closely related cousin (AHFV) is found primarily in Saudi Arabia along the coast of the Red Sea [85]. POWV has been suggested as the most ancestral member of the TBEV serocomplex [1,69] and is the only tick-borne flavivirus found in the Americas.…”

Section: Origins Of Flavivirus Researchmentioning

confidence: 99%

Historical Perspectives on Flavivirus Research

Holbrook¹

2017

Viruses

133

104

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The flaviviruses are small single-stranded RNA viruses that are typically transmitted by mosquito or tick vectors. These “arboviruses” are found around the world and account for a significant number of cases of human disease. The flaviviruses cause diseases ranging from mild or sub-clinical infections to lethal hemorrhagic fever or encephalitis. In many cases, survivors of neurologic flavivirus infections suffer long-term debilitating sequelae. Much like the emergence of West Nile virus in the United States in 1999, the recent emergence of Zika virus in the Americas has significantly increased the awareness of mosquito-borne viruses. The diseases caused by several flaviviruses have been recognized for decades, if not centuries. However, there is still a lot that is unknown about the flaviviruses as the recent experience with Zika virus has taught us. The objective of this review is to provide a general overview and some historical perspective on several flaviviruses that cause significant human disease. In addition, available medical countermeasures and significant gaps in our understanding of flavivirus biology are also discussed.

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“…In recent years there have been reports of KFDV infections in both Karnataka province (Mourya et al, 2013; Yadav et al, 2014) and in the neighboring provinces of Kerala (Tandale et al, 2015; Sadanandane et al, 2017), Tamil Nadu and Maharashtra (Mourya and Yadav, 2016). As in previous reports, outbreaks are often preceded by disease in monkeys, and contact with carcases can lead to infection (Mourya et al, 2013).…”

Section: Emerging Tick-borne Flavivirusesmentioning

confidence: 99%

Emerging Tick-Borne Viruses in the Twenty-First Century

Mansfield

Phipps

et al. 2017

Front. Cell. Infect. Microbiol.

130

107

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Ticks, as a group, are second only to mosquitoes as vectors of pathogens to humans and are the primary vector for pathogens of livestock, companion animals, and wildlife. The role of ticks in the transmission of viruses has been known for over 100 years and yet new pathogenic viruses are still being detected and known viruses are continually spreading to new geographic locations. Partly as a result of their novelty, tick-virus interactions are at an early stage in understanding. For some viruses, even the principal tick-vector is not known. It is likely that tick-borne viruses will continue to emerge and challenge public and veterinary health long into the twenty-first century. However, studies focusing on tick saliva, a critical component of tick feeding, virus transmission, and a target for control of ticks and tick-borne diseases, point toward solutions to emerging viruses. The aim of this review is to describe some currently emerging tick-borne diseases, their causative viruses, and to discuss research on virus-tick interactions. Through focus on this area, future protein targets for intervention and vaccine development may be identified.

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An outbreak of Kyasanur forest disease in the Wayanad and Malappuram districts of Kerala, India

Cited by 37 publications

References 13 publications

Tick-Borne Viruses

Tick-Borne Viruses

Historical Perspectives on Flavivirus Research

Emerging Tick-Borne Viruses in the Twenty-First Century

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