An outbreak of joint and cutaneous infections caused by non-tuberculous mycobacteria after corticosteroid injection

Abstract

Repeated injection of triamcinolone contaminated with NTM from the clinic environment may have caused this post-injection outbreak.

Severe hypercalcemia in a patient with extrapulmonaryMycobacterium abscessus: granuloma or immune reconstitution inflammatory syndrome? First case ofMycobacterium abscessuspresenting as retroperitoneal lymphadenopathy with severe hypercalcemia: a case report and literature review

“…Recently, postsurgical and post-procedure outbreaks of skin and soft tissue infections caused by M. abscessus or Mycobacterium massiliense (M. massiliense) have occurred in several countries. [23][24][25][26][27] Bone and joint infection have been also reported in the form of septic arthritis after medical procedures [28]. However, isolated bone infection with M. abscessus is rare and only one case of vertebral osteomyelitis has been reported [29].…”

Genomic characterization of Nontuberculous Mycobacteria

“…Among NTM species, an increasing number of strains have been deemed responsible, in the last decades, of severe and treatment-resistant diseases910111213. NTMs are present in the environment, in particular in water and soil14, and can occasionally infect humans or animals causing a range of pathological conditions including pulmonary, skin, bone, joint, and disseminated diseases in the presence of various predisposing conditions (primarily chronic diseases and immunosuppression)15161718. Although several NTM species are now recognized as a major infective threat19, their in-depth genomic investigation has not been carried out systematically.…”

Mycobacteriological characteristics and treatment outcomes in extrapulmonary Mycobacterium abscessus complex infections

“…Several outbreaks of septic arthritis caused by MABC after medical procedures have also been reported (Jung et al, 2015;Lee et al, 2016). The treatment response in patients with septic arthritis due to M. massiliense was good after about 12 months of antibiotic treatment with or without surgery (Jung et al, 2015;Lee et al, 2016).…”

“…Several outbreaks of septic arthritis caused by MABC after medical procedures have also been reported (Jung et al, 2015;Lee et al, 2016). The treatment response in patients with septic arthritis due to M. massiliense was good after about 12 months of antibiotic treatment with or without surgery (Jung et al, 2015;Lee et al, 2016). Vertebral osteomyelitis due to NTM is usually caused by slowly growing mycobacteria such as Mycobacterium avium complex or Mycobacterium xenopi, whereas causation by MABC is rare, and additionally, most previous studies have not performed subspecies identification (Garcia et al, 2013;Kim et al, 2016).…”