An Outbreak of <i>Serratia marcescens</i> Infections Related to Contaminated Chlorhexidine

Vigeant, Patrice; Loo, Vivian G.; Bertrand, Céline; Dixon, Catherine; Hollis, R. S.; Pfaller, Michael A.; McLean, A. Peter H.; Briedis, Dalius J.; Perl, Trish M.; Robson, Hugh G.

doi:10.1086/647728

Cited by 26 publications

(10 citation statements)

References 6 publications

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“…The presence of alcohol in oral hygiene products aimed for long‐term use has been associated to different drawbacks (oral cancer, mucositis, etc.) (Winn et al 1991, Shapiro et al 1996), in spite of clear advantages, such as a higher antimicrobial activity (Herrera et al 2003), and a decrease in the risk of bacterial contamination of the product itself (Vigeant et al 1998).…”

Section: Discussionmentioning

confidence: 99%

A randomized clinical trial on the short‐term clinical and microbiological effects of the adjunctive use of a 0.05% chlorhexidine mouth rinse for patients in supportive periodontal care

Santos

Herrera

López

et al. 2003

J Clinic Periodontology

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Section: Discussionmentioning

confidence: 99%

A randomized clinical trial on the short‐term clinical and microbiological effects of the adjunctive use of a 0.05% chlorhexidine mouth rinse for patients in supportive periodontal care

Santos

Herrera

López

et al. 2003

J Clinic Periodontology

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“…), respiratory tract infections (Vigeant et al . ), pneumonia (Jones ), meningitis (Zaidi et al . ), conjunctivitis (McNaughton et al .…”

Section: Introductionmentioning

confidence: 99%

Phytosynthesized silver nanoparticles as antiquorum sensing and antibiofilm agent against the nosocomial pathogenSerratia marcescens: anin vitrostudy

et al. 2018

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“…2,[4][5][6] Furthermore, there are increasing reports of antibiotic-resistant S. marcescens strains associated with nosocomial outbreaks. 2,[4][5][6] Furthermore, there are increasing reports of antibiotic-resistant S. marcescens strains associated with nosocomial outbreaks.…”

Section: Introductionmentioning

confidence: 99%

Cutaneous Serratia marcescens infections in Korea: A retrospective analysis of 13 patients

Seo

Shin

et al. 2015

The Journal of Dermatology

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Serratia marcescens is a Gram-negative bacillus belonging to the Enterobacteriaceae family. Because of increasing reports of antimicrobial resistance, this bacterium has received considerable attention and has emerged as an important pathogen. In order to reveal clinical and microbiological characteristics of S. marcescens cutaneous infection and to suggest appropriate antibiotic treatment, we retrospectively analyzed 17 strains isolated from wound swabs of Korean patients between November 2005 and March 2014. A total of 13 patients (five men and eight women) were included in our study, with a mean age of 46.3 years (range, 21-82). Based on medical history, seven patients were classified as immunocompromised. Prior predisposing factors for infections were noted in 12 patients, including pre-existing leg ulcers or dermatitis (5/13), preceding cancer surgeries (2/13), plastic surgeries and filler injection (2/13), traumas (2/13) and medical procedures following cutaneous abscess (1/13). Cutaneous infections showed various clinical presentations, including spontaneous dermal abscess, fingernail change, painful nodules and papular erosions. We found that third- and fourth-generation cephalosporins, gentamicin, levofloxacin and meropenem appeared active against all 17 strains in vitro. Clinically, all patients treated with empirical first-generation cephalosporin showed treatment resistance, and oral quinolone monotherapy was the most preferred antibiotic regimen without treatment failure, with an average treatment duration of 25 days (range, 14-42). This study demonstrates the various clinical presentations and treatment responses for cutaneous S. marcescens infection. Moreover, we suggest that initial antibiotic coverage should be broad enough to account for multidrug resistance in this rare pathogen.

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An Outbreak of Serratia marcescens Infections Related to Contaminated Chlorhexidine

Cited by 26 publications

References 6 publications

A randomized clinical trial on the short‐term clinical and microbiological effects of the adjunctive use of a 0.05% chlorhexidine mouth rinse for patients in supportive periodontal care

A randomized clinical trial on the short‐term clinical and microbiological effects of the adjunctive use of a 0.05% chlorhexidine mouth rinse for patients in supportive periodontal care

Phytosynthesized silver nanoparticles as antiquorum sensing and antibiofilm agent against the nosocomial pathogenSerratia marcescens: anin vitrostudy

Cutaneous Serratia marcescens infections in Korea: A retrospective analysis of 13 patients

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