An Outbreak of Coronavirus OC43 Respiratory Infection in Normandy, France

Vabret, Astrid; Mourez, Thomas; Gouarin, S.; Petitjean, J.; Freymuth, F.

doi:10.1086/374222

Cited by 225 publications

(228 citation statements)

References 16 publications

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“…N and C-terminal tail peptide bind by cosedimentation in solution (View interaction) N and N bind by cosedimentation in solution (View Interaction: 1,2,3,4,5,6,7,8,9,10,11,12) C-terminal tail peptide and N bind by fluorescence technology (View interaction) N and N bind by cross-linking study (View interaction) N and N bind by cross-linking study (View Interaction: 1,2,3,4) Crown…”

Section: Structured Summary Of Protein Interactionsmentioning

confidence: 99%

Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein

Lin

Wang³

et al. 2012

FEBS Letters

102

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a b s t r a c tThe coronavirus (CoV) N protein oligomerizes via its carboxyl terminus. However, the oligomerization mechanism of the C-terminal domains (CTD) of CoV N proteins remains unclear. Based on the protein disorder prediction system, a comprehensive series of HCoV-229E N protein mutants with truncated CTD was generated and systematically investigated by biophysical and biochemical analyses to clarify the role of the C-terminal tail of the HCoV-229E N protein in oligomerization. These results indicate that the last C-terminal tail plays an important role in dimer-dimer association. The C-terminal tail peptide is able to interfere with the oligomerization of the CTD of HCoV-229E N protein and performs the inhibitory effect on viral titre of HCoV-229E. This study may assist the development of anti-viral drugs against HCoV. Structured summary of protein interactions:N and C-terminal tail peptide bind by cosedimentation in solution (View interaction) N and N bind by cosedimentation in solution (View Interaction: 1,2,3,4,5,6,7,8,9,10,11,12) C-terminal tail peptide and N bind by fluorescence technology (View interaction) N and N bind by cross-linking study (View interaction) N and N bind by cross-linking study (View Interaction: 1,2,3,4) Crown

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Section: Structured Summary Of Protein Interactionsmentioning

confidence: 99%

Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein

Lin

Wang³

et al. 2012

FEBS Letters

102

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“…Two of the HCoV strains (HCoV-OC43 and HCoV-229E) were detected predominantly in individuals with common colds (3)(4)(5)(6). Thereafter, three new HCoV strains were identified via molecular and tissue culture assays: severe acute respiratory syndrome coronavirus (SARS-CoV) (7), coronavirus strain noted in The Netherlands (HCoV-NL63) (8,9), and coronavirus strain noted in Hong Kong (HCoV-HKU1) (10).…”

mentioning

confidence: 99%

Coronavirus Infections in Pediatric Outpatients with Febrile Respiratory Tract Infections in Hiroshima, Japan, over a 3-Year Period

Hara¹,

Takao

2015

Jpn J Infect Dis

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SUMMARY: Previously, we conducted a 3-year prospective study to determine the viral causes of acute respiratory tract infections among 495 febrile pediatric outpatients. We collected 495 nasopharyngeal aspirate specimens, and used both real-time PCR assays and viral culture to test each for respiratory viruses other than coronavirus. Here, we used real-time PCR to test the 495 archival specimens for four human coronavirus strains. We identified 15 coronavirus-positive specimens: eight with OC43, 5 with NL63, 2 with HKU1, and none with 229E. Of the 15 children (5 boys) infected with human coronavirus, the mean age was 3.5 years, and the age range was 1.1 to 5.8 years; one child was diagnosed with lower respiratory infection; the other 14 were diagnosed with upper respiratory infection. Of these 15 patients, none were hospitalized, 5 were infected with coronavirus alone, 8 were co-infected with another virus, and 2 were co-infected with 2 other viruses. The multi-virus infections involved 6 adenoviruses, 3 respiratory syncytial viruses, 2 parainfluenza viruses, and 1 rhinovirus. In conclusion, the burden of human coronaviruses was relatively light among this cohort of 495 pediatric outpatients, and the incidence of these infections was low.

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“…9,10 Human coronavir us, known to cause symptoms associated with the common cold, may also contribute to ILI. 11 To our knowledge, there has been no attempt in Australia to correlate seasonal estimates of ILI activity with any measure of the impact of influenza on the community. We aimed to review the proportion of ILI that could be attributed to influenza infection over f ive consecutive influenza seasons in Victoria and to compare ILI activity with hospital admissions for influenza.…”

mentioning

confidence: 99%

Establishing thresholds for influenza surveillance in Victoria

Watts

Andrews

Druce

et al. 2003

Australian and New Zealand Journal of Public Health

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Objective:We aimed to review the proportion of influenza‐like illness (ILI) that could be attributed to influenza infection over five consecutive influenza seasons in Victoria, to compare ILI activity with hospital admissions for influenza, and to develop thresholds that would indicate when ILI activity may coincide with increases in influenza hospitalisations. Methods:Combined nose/throat swabs from patients with ILI selected from sentinel general practices were tested for influenza and other respiratory viruses at the Victorian Infectious Diseases Reference Laboratory. The proportion of ILI attributed to laboratory‐confirmed influenza was evaluated for five consecutive surveillance seasons, from 1998 to 2002. The seasonal patterns of ILI and laboratory‐confirmed influenza were compared for 2000–02. ILI surveillance from sentinel general practices between 1997 and 2000 was compared with hospital admissions for influenza extracted from the Victorian Admitted Episodes Dataset between 1994 and 2000. Results:Approximately 41% of all ILI cases from sentinel general practices were confirmed to have an influenza infection between 1998 and 2002. The seasonal pattern of ILI and confirmed influenza among patients selected from sentinel general practices was very similar over three influenza seasons. The trends for ILI rates in sentinel general practices appeared to correlate remarkably well with those of hospital admissions for influenza. Thresholds for ILI were defined as: baseline <0.25 ILI cases/100 patients/week; normal seasonal activity 0.25–1.5; above normal seasonal activity >1.5–3.5; and epidemic activity above 3.5. Conclusion:ILI rates from sentinel general practices correspond with hospital admissions coded as influenza and allow the use of threshold levels to describe seasonal influenza activity.

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An Outbreak of Coronavirus OC43 Respiratory Infection in Normandy, France

Cited by 225 publications

References 16 publications

Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein

Oligomerization of the carboxyl terminal domain of the human coronavirus 229E nucleocapsid protein

Coronavirus Infections in Pediatric Outpatients with Febrile Respiratory Tract Infections in Hiroshima, Japan, over a 3-Year Period

Establishing thresholds for influenza surveillance in Victoria

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