An Outbreak of Acute Post-Cataract Surgery Pseudomonas sp. Endophthalmitis Caused by Contaminated Hydrophilic Intraocular Lens Solution

Postoperative endophthalmitis due toBurkholderia cepaciacomplex from contaminated anaesthetic eye drops

“…with very poor visual outcome 2 22. In this study, we report cluster endophthalmitis occurring at a single facility that was traced to eye drops contaminated with B. cepacia .…”

“…Ramappa et al reported an outbreak of P. aeruginosa endophthalmitis in which the source was identified from intraocular lens solutions 2. Intrinsically contaminated ophthalmic solutions, such as balanced salt solution, hyaluronic acid, Trypan blue, miochol, internal fluid pathways of a phacoemulsification unit and a contaminated phacoemulsification hand piece, have all been implicated 3–5 23.…”

Comparison of clinico-microbiological profile and treatment outcome of in-house and referred post cataract surgery endophthalmitis in a tertiary care center in South India

“…These 50 cases were matched with the first 50 consecutive culture-positive referred cases in the same period (group B; beginning December 2014 backwards and ending March 2010). Two cluster endophthalmitis cases, one in-house (reported earlier) [4] and one referred (reported by another treating center) [5] were excluded from both groups. Institutional review board approval (LEC 09-15-110) was obtained for retrospective data collection and analysis.…”

Reply

“…2 It would be of interest to know if the cause of the outbreak was discovered given prior experience with similar outbreaks related to contaminated ophthalmic solutions. 3-6 While thankfully in our series all organisms were sensitive to initially administered intravitreal therapy, managing multidrug resistant (MDR) P. aeruginosa is a challenge that is now real, rather than theoretical. Jindal et al previously administered intravitreal imipenem for MDR P. aeruginosa , and Arora et al have now demonstrated intravitreal piperacillin-tazobactam as an alternative.…”