An Outbreak of Acute Arsenic Poisoning Caused by Arsenic Contaminated Soy-Sauce (Shoyu): A Clinical Report of 220 Cases

Mizuta, Nobuo; Mizuta, Minoru; Ito, Fukashi; Ito, Tsunesuke; Uchida, Hiroyuki; Watanabe, Yutaka; Akama, Hiroshi; Murakami, Tadashi; Hayashi, Fumiya; Nakamura, Katsue; Yamaguchi, Takao; Mizuta, W; Oishi, Shozo; Matsumura, Hiroshi

doi:10.2169/naika.45.867

Cited by 13 publications

(40 citation statements)

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“…Hence, symptoms associated with arsenic intoxication in that study will be higher for residents of Dumasi. Mizuta et al (1956), also reported a poisoning incident involving the presence of arsenic contained in soysauce. An early feature of the poisoning was the appearance of facial edema that was marked on the eyelids, gastrointestinal symptoms, liver enlargement, upper respiratory symptoms, peripheral neuropathy and skin disorders.…”

Section: Resultsmentioning

confidence: 99%

Determination of Heavy Metals in Water from Boreholes in Dumasi in the Wassa West District of Western Region of Republic of Ghana

Obiri

2007

Environ Monit Assess

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Concentrations of heavy metals in the borehole at Dumasi in the Wassa West District of the Republic of Ghana have been measured in this study. The concentrations of the following metals in the ground water from Dumasi borehole are: Iron (Fe) - 7.52 ppm, Manganese (Mn) - 1.11 ppm, Arsenic (As) - 4.52 ppm, Chromium (Cr) - 0.026 ppm, Cobalt (Co) - 0.01 ppm, Zinc (Zn) - 0.007 ppm, Cadmium (Cd) - 0.002 ppm and Lead (Pb) - 0.005 ppm. The results of the study show that resident adults and children who use water from the boreholes are at serious risk from exposure to health hazards associated with exposure to the above metals in the boreholes in Dumasi. If the results of this study are applied to other mining communities, which lie on the Birimian and Tarkwaian rock system, then the residents are at serious risk from exposure to toxic metals from drinking water from the boreholes dag for them by mining companies operating in their communities.

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Section: Resultsmentioning

confidence: 99%

Determination of Heavy Metals in Water from Boreholes in Dumasi in the Wassa West District of Western Region of Republic of Ghana

Obiri

2007

Environ Monit Assess

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“…Oral exposure (inorganic arsenic) Gastrointestinal effects Vomiting, diarrhea, abdominal pain, inflammation, bleeding or ulceration of the gastrointestinal tract Humans Armstrong et al (1984); Civantos et al (1995); Cullen et al (1995); Fincher and Koerker (1987); Franzblau and Lilis (1989); Goebel et al (1990); Kamijo et al (1998) Anemia, pancytopenia and leukopenia Humans Armstrong et al (1984); Fincher and Koerker (1987); Franzblau and Lilis (1989); Hopenhayn et al (2006); Mizuta et al (1956) …”

Section: Effect Description Species Referencesmentioning

confidence: 99%

A review on exposure and effects of arsenic in passerine birds

Sánchez‐Virosta

Espín

García-Fernández

et al. 2015

Science of The Total Environment

103

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“…There were also cardiac abnormalities and hearing loss among the patients. Ir~ another incident involving As-contaminated soy sauce, there were no deaths among the 220 persons studied (Mizuta et al, 1956). Primary effects included oedema, gastrointestinal disturbances, enlarged livers, cardiac abnormalities and neuritis.…”

Section: Humansmentioning

confidence: 92%

“…In 1900, sugar, contaminated with As, used in beer production killed more than 70 people and poisoned 6,000 more (Kelynack et aL, 1900). In Japan, there were acute poisoning incidences due to As contamination of powdered milk (Hamamoto, 1955) and soy sauce (Mizuta et al, 1956). In Virginia, contaminated well water caused one death and illness in eight other family members (Armstrong et al, 1984).…”

Section: Historymentioning

confidence: 99%

Non-carcinogenic effects of inorganic arsenic

Abernathy

Ohanian

1992

Environ Geochem Health

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This review will focus primarily on ohe effects of the inorganic arsenicals (arsenate and arsenite forms) that are present in drinking water. They are acutely toxic to both humans and animals, an effect that may be related to their bioavailibility. In humans, arsenicals have been reported to cause dermatitis and mucous membrane irritation upon exposure. They have also been reported to cause skin lesions and peripheral neurotoxicity in smelter workers and in patients treated with Fowler's Solution. When humans are exposed to arsenic in drinking water, effects such as hyperkeratosis, electromyographic abnormalities and vascular effects have been reported. In experimental animals, arsenic has been demonstrated to affect the liver and kidneys. In mice, arsenic has also been reported to decrease the animal's resistance to certain viral infections. The arsenite (+3) and arsenate (+5) forms have different modes of action. Arsenite binds to sulphhydryl groups and has been reported to inhibit over 100 different enzymes, while the arsenate can substitute for phosphate in various high energy intermediates, resulting in arsenolysis. In addition, when arsenate is reduced to arsenite in the body, it can also cause toxicity as that species.

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An Outbreak of Acute Arsenic Poisoning Caused by Arsenic Contaminated Soy-Sauce (Shoyu): A Clinical Report of 220 Cases

Cited by 13 publications

References 0 publications

Determination of Heavy Metals in Water from Boreholes in Dumasi in the Wassa West District of Western Region of Republic of Ghana

Determination of Heavy Metals in Water from Boreholes in Dumasi in the Wassa West District of Western Region of Republic of Ghana

A review on exposure and effects of arsenic in passerine birds

Non-carcinogenic effects of inorganic arsenic

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