An Outbreak of Accidental Vaccinia in a Family*

Andreev, V.C.; Lachapelle, Jean‐Marie; Rook, A

doi:10.1111/j.1365-4362.1969.tb05320.x

Cited by 11 publications

(8 citation statements)

References 8 publications

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“…27 An unusual aspect of the family outbreaks of vaccinia was the apparent tendency for lesions to be present in similar anatomical areas in all secondary cases, including the mouth 32 and the face. 31,34 The mucosa may be involved because vaccinia can penetrate more easily into this tissue than into skin. [34][35][36][37][38][39][40] Eyelids, lips, nose, and vulva were most commonly reported.…”

mentioning

confidence: 99%

How Contagious Is Vaccinia?

Sepkowitz

2003

N Engl J Med

104

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confidence: 99%

How Contagious Is Vaccinia?

Sepkowitz

2003

N Engl J Med

104

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“…Vulvar vaccinia infections often are characterized by painful labial ulcers and/or vesicles, vulvar edema and pruritus, vaginal discharge, and occasionally by vaginitis and tender bilateral inguinal lymphadenopathy. [3][4][5][6][7][8][9] Most reports of vulvar vaccinia were published before cessation of widespread smallpox vaccination programs 7 ; however, in addition to the case described in this report, laboratory-confirmed cases of vulvar vaccinia after sexual contact with vaccinated military personnel have been reported in New York and Texas since the U.S. military resumed smallpox vaccination in 2002. 8,9 Similar to the case described in this report, herpes virus infection was initially suspected in the New York case, and information regarding contact with a recent smallpox vaccinee was not disclosed until after laboratory evidence of vaccinia virus had been detected.…”

Section: Cdc Editorial Notementioning

confidence: 96%

Vulvar Vaccinia Infection After Sexual Contact With a Military Smallpox Vaccinee—Alaska, 2006

2007

JAMA

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ON OCTOBER 10, 2006, AN OTHERWISE healthy woman visited a public health clinic in Alaska after vaginal tears that she had first experienced 10 days before became increasingly painful. The patient reported having a new male sex partner during September 22-October 1, 2006. A viral swab specimen from a labial lesion of the woman was submitted to the Alaska State Virology Laboratory (ASVL) for viral culture. The viral isolate could not be identified initially and subsequently was sent to CDC on January 9, 2007, where the isolate was identified as a vaccine-strain vaccinia virus. After vaccinia was identified, investigators interviewed the woman more closely and learned that her new sex partner was a male U.S. military service member stationed at a local military base. Further investigation determined that the service member had been vaccinated for smallpox 3 days before beginning his relationship with the woman. This report describes the clinical evaluation of the woman and laboratory testing performed to identify the isolate. Health-care providers should be aware of the possibility of vaccinia infection in persons with clinically compatible genital lesions who have had recent contact with smallpox vaccinees.

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“…[17][18] Ten cases of infection by those viruses presumably transmitted through sexual contact have been reported in association with vaccination programs in the USA and Israel. [19][20][21] Moreover, one case of vaccinia infection has been reported in a pregnant woman bitten by a dog previously vaccinated against rabies with a recombinant Vaccinia virus. 22 …”

Section: Introductionmentioning

confidence: 99%

Clinical signs, diagnosis, and case reports of Vaccinia virus infections

Silva¹,

Moreira-Silva²,

Gomes³

et al. 2010

Braz J Infect Dis

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We declare no confl ict of interest. ABSTRACTVaccinia virus is responsible for a zoonosis that usually affects cattle and human beings in Brazil. The initial clinical signs of the infection are focal red skin areas, fever, and general symptoms similar to those of a cold. Then, pustules and ulcerated lesions surrounded by edema and erythema follow, as well as local lymphadenopathy that can last for weeks. Cure and healing of the lesions occur over several weeks, leaving a typical scar in the skin of people and animals affected. The infection defi nitive diagnosis is made through morphological characterization of the virus by use of electron microscopy, followed by PCR for specifi c viral genes. Since 1963, circulating orthopoxviruses in infectious outbreaks in several regions of Brazil have been reported. Later, the etiological agent of those infections was characterized as samples of Vaccinia virus. In addition, the widespread use of those viruses in research laboratories and mass vaccination of militaries have contributed to increase the cases of those infections worldwide. Thus, several epidemiological and clinical studies are required, as well as studies of viral immunology, public health, and economic impact, because little is known about those Vaccinia virus outbreaks in Brazil.

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An Outbreak of Accidental Vaccinia in a Family*

Cited by 11 publications

References 8 publications

How Contagious Is Vaccinia?

How Contagious Is Vaccinia?

Vulvar Vaccinia Infection After Sexual Contact With a Military Smallpox Vaccinee—Alaska, 2006

Clinical signs, diagnosis, and case reports of Vaccinia virus infections

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