An outbreak caused by GII.17 norovirus with a wide spectrum of HBGA-associated susceptibility

Zhang, Xu-Fu; Huang, Qiong; Yan, Lei; Jiang, Xi; Zhang, Ting; Tan, Ming; Zhang, Qiao‐Li; Huang, Zhenyu; Li, Yue-Huan; Ding, Yao-Quan; Hu, Guifang; Tang, Shixing; Dai, Ying-Chun

doi:10.1038/srep17687

Cited by 69 publications

(64 citation statements)

References 39 publications

(57 reference statements)

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“…However, recent molecular epidemiological studies have speculated that GII.17 noroviruses might replace the GII.4 noroviruses, since their prevalence appears to be increasing worldwide (12). One possible reason for the recent increase in the prevalence of GII.17 noroviruses might be related to a change in their HBGA binding profiles (13,14). The previous nonprevalent GII.17 noroviruses were thought to bind poorly to HBGAs, while the more recent GII.17 noroviruses that appeared in 2014 and 2015 might bind a greater panel of HBGA types (13,14).…”

Section: Human Norovirus and Histo-blood Group Antigensmentioning

confidence: 99%

“…One possible reason for the recent increase in the prevalence of GII.17 noroviruses might be related to a change in their HBGA binding profiles (13,14). The previous nonprevalent GII.17 noroviruses were thought to bind poorly to HBGAs, while the more recent GII.17 noroviruses that appeared in 2014 and 2015 might bind a greater panel of HBGA types (13,14). On the other hand, a nonprevalent GII.10 norovirus isolated in 2004 bound numerous HBGA types, and yet this genotype remains relatively rare (15,16).…”

Section: Human Norovirus and Histo-blood Group Antigensmentioning

confidence: 99%

“…Interestingly, these genotypes contain the common set of fucose binding residues observed in GII.4 and GII.10 noroviruses. On the other hand, the recent GII.17 noroviruses may have acquired the ability to bind HBGAs (13,14). The earlier nonprevalent GII.17 noroviruses had a valine residue at the HBGA pocket (Val444 [GII.17 numbering]) which was typically a tyrosine residue (Tyr444 [GII.4 numbering]) and which provided a critical hydrophobic interaction to the fucose methyl group (19).…”

Section: Structural Basis For Norovirus Binding To Hbgasmentioning

confidence: 99%

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Human Norovirus Interactions with Histo-Blood Group Antigens and Human Milk Oligosaccharides

Schroten

Hanisch

Hansman

2016

J Virol

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Human noroviruses interact with both human histo-blood group antigens (HBGAs) and human milk oligosaccharides (HMOs). The former are believed to be important for a virus infection, while the latter might act as natural decoys in the host during an infection. However, certain noroviruses are known to bind poorly to HBGAs and yet still cause infections; some interact with numerous HBGA types but are nonprevalent; and yet others bind HBGAs and seem to be increasing in prevalence. HBGAs and HMOs can be found as soluble antigens in humans, can be structurally alike, and can interact with equivalent residues at identical binding pockets on the capsid. In this Gem, we discuss HBGA and HMO binding studies for human noroviruses, concentrating on the clinically important genogroup II noroviruses. In short, the roles of HBGA and HMO interactions in norovirus infections are still unclear. Human noroviruses are the dominant cause of outbreaks of acute gastroenteritis. These viruses are also responsible for significant numbers of sporadic infections, are often found in asymptomatic cases, can cause chronic infections, and infect all age groups. Noroviruses are transmitted via the fecal-oral route, and infections often result from consumption of contaminated foods such as bivalves (clams and oysters). Noroviruses have a single-stranded, positive-sense RNA genome of ϳ7.5 kb. The genome contains three open reading frames (ORFs): ORF1 encodes nonstructural proteins, ORF2 encodes a capsid protein (VP1), and ORF3 encodes a minor capsid protein. Human norovirus is difficult to grow in cell cultures, and the exact locations of the cells and the cell type(s) that norovirus infect remain unknown. Expression of the capsid protein in insect cells can generate selfassembled virus-like particles (VLPs) that are morphologically and antigenically similar to the native virion (1). The norovirus particle is composed of 180 copies of VP1, which forms 90 VP1 homodimers. The X-ray crystal structure of norovirus VLPs identified two main domains, the shell (S) domain and the protruding (P) domain (2). The S domain surrounds the viral RNA, whereas the P domain is further subdivided into P1 and P2 subdomains and contains determinants for cell attachment and antigenicity. HUMAN NOROVIRUS AND HISTO-BLOOD GROUP ANTIGENSHuman noroviruses are known to interact with histo-blood group antigens (HBGAs), and this interaction could be important for infection (3-7). HBGAs can be found as soluble antigens in saliva and are expressed on the mucosal epithelium of the digestive tract. Therefore, noroviruses could interact several times with HBGAs during the course of an infection. Interestingly, human noroviruses can naturally bioaccumulate in bivalves, where they are thought to bind HBGA-like carbohydrates in the gastrointestinal epithelial cells (8). However, this accumulation does not appear to cause harm to the bivalves.Multiple gene families control human HBGA biosynthesis through the action of glycosyltransferases (9). As HBGAs can be either lipid or protein ...

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Section: Human Norovirus and Histo-blood Group Antigensmentioning

confidence: 99%

Section: Human Norovirus and Histo-blood Group Antigensmentioning

confidence: 99%

Section: Structural Basis For Norovirus Binding To Hbgasmentioning

confidence: 99%

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Human Norovirus Interactions with Histo-Blood Group Antigens and Human Milk Oligosaccharides

Schroten

Hanisch

Hansman

2016

J Virol

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“…China [15,[20][21][22][23][24][25][26][27][28][29][30][31][32] . It attacked Beijing, Guang--dong, Hebei, Jiangsu, Zhejiang, Taiwan and Hongkong [20][21][22][23][24][25][26][27][28][29][30][31][32] .…”

Section: Gii4 Syndey As the Course Of Outbreaks Inmentioning

confidence: 99%

“…It attacked Beijing, Guang--dong, Hebei, Jiangsu, Zhejiang, Taiwan and Hongkong [20][21][22][23][24][25][26][27][28][29][30][31][32] . Besides, other rare prevalent genotypes were also confirmed, including GII.6 [33,34] and GIV.1 [35] .…”

Section: Gii4 Syndey As the Course Of Outbreaks Inmentioning

confidence: 99%

Norovirus, the Next Target for Vaccine Development in China

Du¹,

Guo²

2017

J. Appl. Virol.

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Enteric virus-induced disease, even death, greatly affects the life quality of children <5 years of age in China, and imposes a heavy sociometric burden on family and government. The infectious diarrhea diseases and hand-foot-mouth disease (HFMD) have been enrolled in the list of notifiable infectious diseases in China. Fortunately, the highly valued rotavirus-induced diarrhea and enterovirus 71-induced HFMD can be prevented by the commercial vaccines. However, the underrated norovirus vaccine is still in progress, even norovirus was considered as the leading cause of acute gastroenteritis in children <5 years of age in the world, partially due to the inability to cultivate norovirus. Besides, the broad genetic and serotypic diversity of norovirus also complicates selection of candidate vaccine strain(s). Therefore, the primary objective of this article is to review norovirus epidemics in China recur to the data published in recent five years.

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Norovirus Correlates of Protection

Melhem

Hassan

2019

Norovirus

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An outbreak caused by GII.17 norovirus with a wide spectrum of HBGA-associated susceptibility

Cited by 69 publications

References 39 publications

Human Norovirus Interactions with Histo-Blood Group Antigens and Human Milk Oligosaccharides

Human Norovirus Interactions with Histo-Blood Group Antigens and Human Milk Oligosaccharides

Norovirus, the Next Target for Vaccine Development in China

Norovirus Correlates of Protection

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