An orthogonally activatable CRISPR-Cas13d nanoprodrug to reverse chemoresistance for enhanced chemo-photodynamic therapy

Zheng, Ling; Feng, Zhi-Yuan; Chen, Mohan; Zhan, Jiayin; Wu, Rong; Shi, Yang; Xue, Yun-Shan; Liu, Ran; Zhu, Jun‐Jie; Zhang, Jingjing

doi:10.1039/d3sc00020f

Cited by 9 publications

(5 citation statements)

References 44 publications

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“…From this perspective, Z. Liu et al have developed a UCNP-based drug-delivery system for synergistic anticancer therapy [218] (Figure 14). To develop an advanced therapeutic system, they synthesized a green light-activatable anticancer prodrug and UV light activatable gene-gene editing sequences.…”

Section: Photo-responsive Nanoparticle Drug-delivery Systems For Anti...mentioning

confidence: 99%

Aptamer-Based Smart Targeting and Spatial Trigger–Response Drug-Delivery Systems for Anticancer Therapy

Park,

Lee,

Park

2024

Biomedicines

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In recent years, the field of drug delivery has witnessed remarkable progress, driven by the quest for more effective and precise therapeutic interventions. Among the myriad strategies employed, the integration of aptamers as targeting moieties and stimuli-responsive systems has emerged as a promising avenue, particularly in the context of anticancer therapy. This review explores cutting-edge advancements in targeted drug-delivery systems, focusing on the integration of aptamers and stimuli-responsive platforms for enhanced spatial anticancer therapy. In the aptamer-based drug-delivery systems, we delve into the versatile applications of aptamers, examining their conjugation with gold, silica, and carbon materials. The synergistic interplay between aptamers and these materials is discussed, emphasizing their potential in achieving precise and targeted drug delivery. Additionally, we explore stimuli-responsive drug-delivery systems with an emphasis on spatial anticancer therapy. Tumor microenvironment-responsive nanoparticles are elucidated, and their capacity to exploit the dynamic conditions within cancerous tissues for controlled drug release is detailed. External stimuli-responsive strategies, including ultrasound-mediated, photo-responsive, and magnetic-guided drug-delivery systems, are examined for their role in achieving synergistic anticancer effects. This review integrates diverse approaches in the quest for precision medicine, showcasing the potential of aptamers and stimuli-responsive systems to revolutionize drug-delivery strategies for enhanced anticancer therapy.

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Section: Photo-responsive Nanoparticle Drug-delivery Systems For Anti...mentioning

confidence: 99%

Aptamer-Based Smart Targeting and Spatial Trigger–Response Drug-Delivery Systems for Anticancer Therapy

Park,

Lee,

Park

2024

Biomedicines

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“…Liu et al graded controlled functional blocks for synergistic therapy using orthogonal emissions from UCNPs (Figure 8c). [229] Ho 3+ emission under 980 nm excitation activated Pt (IV) prodrugs. The emitted photons were absorbed by an RB photosensitizer for PDT.…”

Section: All-in-one Therapymentioning

confidence: 99%

mentioning

confidence: 99%

Near‐Infrared‐Responsive Rare Earth Nanoparticles for Optical Imaging and Wireless Phototherapy

Du,

Wei,

Liang

et al. 2023

Advanced Science

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Near‐infrared (NIR) light is well‐suited for the optical imaging and wireless phototherapy of malignant diseases because of its deep tissue penetration, low autofluorescence, weak tissue scattering, and non‐invasiveness. Rare earth nanoparticles (RENPs) are promising NIR‐responsive materials, owing to their excellent physical and chemical properties. The 4f electron subshell of lanthanides, the main group of rare earth elements, has rich energy‐level structures. This facilitates broad‐spectrum light‐to‐light conversion and the conversion of light to other forms of energy, such as thermal and chemical energies. In addition, the abundant loadable and modifiable sites on the surface offer favorable conditions for the functional expansion of RENPs. In this review, the authors systematically discuss the main processes and mechanisms underlying the response of RENPs to NIR light and summarize recent advances in their applications in optical imaging, photothermal therapy, photodynamic therapy, photoimmunotherapy, optogenetics, and light‐responsive drug release. Finally, the challenges and opportunities for the application of RENPs in optical imaging and wireless phototherapy under NIR activation are considered.

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“…Specifically, the cationic polymer was synthesized by simple covalent modification of PLL with the Rose Bengal (RB) photosensitizer, whose absorbance spectra exhibit a maximum overlap with the green upconversion luminescence band of UCNPs. 39 Considering that commercial dBET6 is a heterobifunctional small molecule for BRD4 protein degradation, 40 we use dBET6 as a model PROTAC to disrupt the oncogenic processes. We demonstrated that USDPR exhibits outstanding competencies of membrane disruption by the ROS generated via the energy transferred from the UCNPs to photosensitizers for efficiently boosting the endo/lysosomal escape of PROTACs into the cytoplasm.…”

Section: Introductionmentioning

confidence: 99%

A photoactivatable upconverting nanodevice boosts the lysosomal escape of PROTAC degraders for enhanced combination therapy

Zhan,

Li,

et al. 2024

Biomater. Sci.

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An orthogonally activatable CRISPR-Cas13d nanoprodrug to reverse chemoresistance for enhanced chemo-photodynamic therapy

Abstract: Orthogonal therapy that combines CRISPR-based gene editing and prodrug-based chemotherapy is a promising approach to combat multidrug-resistant cancer. However, its potency to precisely regulate different therapeutic modalities in vivo is...

Cited by 9 publications

References 44 publications

Aptamer-Based Smart Targeting and Spatial Trigger–Response Drug-Delivery Systems for Anticancer Therapy

Aptamer-Based Smart Targeting and Spatial Trigger–Response Drug-Delivery Systems for Anticancer Therapy

Near‐Infrared‐Responsive Rare Earth Nanoparticles for Optical Imaging and Wireless Phototherapy

A photoactivatable upconverting nanodevice boosts the lysosomal escape of PROTAC degraders for enhanced combination therapy

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