Abstract:Ethyl diazepane carboxylate catalyzes the oxy-Cope rearrangement of 4-hydroxy-and 4-alkoxy-1,5-hexadiene-2carboxaldehydes via iminium ion activation. The resulting intermediate undergoes an intramolecular Michael reaction to furnish cyclopentane-containing products. The reaction proceeds with a range of substrates, including both cyclic and acyclic substrates, and tolerates substitution on the vinyl substituent. Substrates fused on a cycloalkane framework undergo net ring expansion/ cyclopentannulation with a … Show more
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