2023
DOI: 10.1021/acs.orglett.2c04269
|View full text |Cite
|
Sign up to set email alerts
|

An Organocatalytic Oxy-Cope/Michael Cascade Reaction

Abstract: Ethyl diazepane carboxylate catalyzes the oxy-Cope rearrangement of 4-hydroxy-and 4-alkoxy-1,5-hexadiene-2carboxaldehydes via iminium ion activation. The resulting intermediate undergoes an intramolecular Michael reaction to furnish cyclopentane-containing products. The reaction proceeds with a range of substrates, including both cyclic and acyclic substrates, and tolerates substitution on the vinyl substituent. Substrates fused on a cycloalkane framework undergo net ring expansion/ cyclopentannulation with a … Show more

Help me understand this report

Search citation statements

Order By: Relevance

Paper Sections

Select...

Citation Types

0
0
0

Publication Types

Select...

Relationship

0
0

Authors

Journals

citations
Cited by 0 publications
references
References 53 publications
(35 reference statements)
0
0
0
Order By: Relevance

No citations

Set email alert for when this publication receives citations?