An Organic–Inorganic Hybrid Nanocomposite as a Potential New Biological Agent

Abstract

To solve the problem of human diseases caused by a combination of genetic and environmental factors or by microorganisms, intense research to find completely new materials is required. One of the promising systems in this area is the silver-silica nanocomposites and their derivatives. Hence, silver and silver oxide nanoparticles that were homogeneously distributed within a silica carrier were fabricated. Their average size was d = (7.8 ± 0.3) nm. The organic polymers (carboxymethylcellulose (CMC) and sodium alginate (AS)) were added to improve the biological features of the nanocomposite. The first system was prepared as a silver chlorine salt combination that was immersed on a silica carrier with coagulated particles whose size was d = (44.1 ± 2.3) nm, which coexisted with metallic silver. The second system obtained was synergistically interacted metallic and oxidized silver nanoparticles that were distributed on a structurally defective silica network. Their average size was d = (6.6 ± 0.7) nm. Physicochemical and biological experiments showed that the tiny silver nanoparticles in Ag/SiO2 and Ag/SiO2@AS inhibited E. coli, P. aeruginosa, S. aureus, and L. plantarum’s cell growth as well as caused a high anticancer effect. On the other hand, the massive silver nanoparticles of Ag/SiO2@CMC had a weaker antimicrobial effect, although they highly interacted against PANC-1. They also generated reactive oxygen species (ROS) as well as the induction of apoptosis via the p53-independent mechanism.

Targeting the Gut: A Systematic Review of Specific Drug Nanocarriers

“…The coating of mesoporous silica nanoparticles with various molecules, such as (3-Glycidyloxypropyl) trimethoxysilane (3GPS), can improve drug delivery and cancer cell targeting, as demonstrated in the work by Asiri et al [ 142 ]. Other solutions foresee the use of alginate-coated mesoporous silica nanoparticles in colon cancer therapy [ 143 , 144 ]. Yang et al developed mesoporous silica nanoparticles coated with HA to enhance the colon targeting that relies on HA pH responsivity [ 145 , 146 ].…”

Multifaceted Assessment of Porous Silica Nanocomposites: Unraveling Physical, Structural, and Biological Transformations Induced by Microwave Field Modification

“…Additionally, bands around 805 and 1035 cm −1 related to Q 4 units (SiO 2 ) in fully polymerized silica structures were observed. Silicas that were subjected to a longer microwave treatment (AR 1.2 and AR 2.2) exhibited additional bands around 634, 686, and 1087 cm −1 originating from Si-O* vibrations within the metal-activated Q 1 and Q 3 units [ 79 , 84 , 85 , 86 ], indicating a potential capillary effect and enhanced metal capture.…”

Spherical Silica Functionalized by 2-Naphthalene Methanol Luminophores as a Phosphorescence Sensor

“…Other bands found below 1250 cm −1 are related to the silica units. In the -COOH-containing samples, spectra are characterized by four bands at 1090, 1043, 988, and 960 cm −1 , which suggest the formation of substructures with terminal oxygen atoms located within the Q 3 , Q 4 , and Q 2 units, and indicate stronger structural disordering [26,27]. All bands may indicate the depolymerization of the silica network due to the synthesis and formation of non-bridging oxygen molecular fragments (NBO), which facilitate the anchoring of the propyl-carbonate [20,26].…”