“…Among the agents used to alleviate these conditions are H 1 -blockers (Bergman and Spealman, 1988;Tonato et al, 1994), D 2 -blockers (Jovanovic-Micic et al, 1995;Mystakidou et al, 1998), 5-hydroxytryptamine 3 blockers (Gregory and Ettinger, 1998;Ye et al, 2001), and cannabinoids (Abrahamov et al, 1995;Mechoulam and Hanu, 2001). More recently, efforts have been made to determine the efficacy of NK 1 receptor 1 antagonists against chemotherapy-induced nausea and vomiting (Bountra et al, 1993;Tattersall et al, 1994;Beattie et al, 1995;Gardner et al, 1995Gardner et al, , 1996Harrison et al, 2001). Using the ferret, it has been established that brain penetration of NK 1 antagonists is essential to prevent drug-induced (cisplatin) emesis, and several compounds have been shown to be efficacious in this regard (Watson et al, 1995;Gonsalves et al, 1996;Rudd et al, 1996;Tattersall et al, 1996;Rupniak et al, 1997;Singh et al, 1997;Zaman et al, 2000;Harrison et al, 2001).…”