An oral absorbent, surface-deacetylated chitin nano-fiber ameliorates renal injury and oxidative stress in 5/6 nephrectomized rats

Anraku, Makoto; Tabuchi, Ryo; Ifuku, Shinsuke; Nagae, Tomone; Iohara, Daisuke; Tomida, Hisao; Uekama, Kaneto; Maruyama, Toru; Miyamura, Shigeyuki; Hirayama, Fumitoshi; Otagiri, Masaki

doi:10.1016/j.carbpol.2016.12.057

Cited by 35 publications

(17 citation statements)

References 30 publications

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“…Moreover, we outlined that ROS release was significantly reduced in the presence of AST-120, due to its absorption of some uremic toxins. These evidences agree with a previous study reporting the AST-120 capability to improve intestinal function in CKD and supporting, in particular its antioxidant effects during CKD [51,52]. In fact, clinical trials have demonstrated that AST-120 reduces serum IS levels in a dose-dependent manner, thus ameliorating renal function decline, improving at least some symptoms of uremia [53], and reducing oxidative stress [54,55,56].…”

Section: Discussionsupporting

confidence: 90%

Effect of Indoxyl Sulfate on the Repair and Intactness of Intestinal Epithelial Cells: Role of Reactive Oxygen Species’ Release

Adesso

Ruocco

Rapa

et al. 2019

IJMS

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Chronic kidney disease (CKD) is characterized by an oxidative stress status, driving some CKD-associated complications, even at the gastrointestinal level. Indoxyl Sulfate (IS) is a protein-bound uremic toxin, poorly eliminated by dialysis. This toxin is able to affect the intestinal system, but its molecular mechanism/s in intestinal epithelial cells (IECs) remain poorly understood. This study’s aim was to evaluate the effect of IS (31.2–250 µM) on oxidative stress in IEC-6 cells and on the intactness of IECs monolayers. Our results indicated that IS enhanced oxidative cell damage by inducing reactive oxygen species (ROS) release, reducing the antioxidant response and affecting Nuclear factor (erythroid-derived 2)-like 2 (Nrf2) nuclear translocation as well its related antioxidant enzymes. In the wound healing assay model, IS reduced IEC-6 migration, slightly impaired actin cytoskeleton rearrangement; this effect was associated with connexin 43 alteration. Moreover, we reported the effect of CKD patients’ sera in IEC-6 cells. Our results indicated that patient sera induced ROS release in IEC-6 cells directly related to IS sera content and this effect was reduced by AST-120 serum treatment. Results highlighted the effect of IS in inducing oxidative stress in IECs and in impairing the intactness of the IECs cell monolayer, thus significantly contributing to CKD-associated intestinal alterations.

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Section: Discussionsupporting

confidence: 90%

Effect of Indoxyl Sulfate on the Repair and Intactness of Intestinal Epithelial Cells: Role of Reactive Oxygen Species’ Release

Adesso

Ruocco

Rapa

et al. 2019

IJMS

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“…Makoto Anraku et al reported that surface-deacetylated chitin nanobers had a superior binding capacity on indole and are more effective in decreasing renal injury and oxidative stress than deacetylated chitin powder in 5/6 nephrectomized rats. 9 This proved the nanobrillation effect of chitin with respect to its propertyfunction. Thus, it is interesting to investigate chitin nanober-/nanowhisker-based hydrogels for wastewater treatment due to the following characteristics: (1) a DDA value lower than 30%, and partial deacetylation occurred on the bril surface; (2) a relatively higher mechanical strength; (3) the assembly of chitin nanobers/nanowhiskers forms a nanobrillar network and porous structure.…”

Section: Introductionmentioning

confidence: 90%

Adsorption of Reactive Blue 19 from aqueous solution by chitin nanofiber-/nanowhisker-based hydrogels

Liu

Wang

et al. 2018

RSC Adv.

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Physical hydrogels prepared from partially deacetylated chitin nanofibers/nanowhiskers (DEChNs) were prepared and evaluated as a new adsorbent for Reactive Blue 19 (RB19) solutions. The effects of pH, initial dye concentration, contact time and temperature were investigated. The optimum pH value for the adsorption experiments was found to be 1.0; as pH increases, the dye adsorption capacity decreases gradually. The adsorption of RB19 onto partially deacetylated chitin nanofiber-/nanowhisker-based hydrogels (DEChNs-Gels) was relatively fast, as the equilibrium could be reached in almost 20 min. The maximum adsorption capacity was found to be 1331 mg g), considering the practical applications, the adsorption capacity in pH ¼ 5 (838 mg g À1) was believed to have more practical significance. A pseudo-second-order kinetics model agreed very well with the experimental results. Equilibrium data also fitted well to the Freundlich adsorption isotherm model in this study. The DEChNs-Gels exhibited a high efficiency for removing RB19 from aqueous solutions as a result of their nanofibrillar network and excellent pore structure accompanied by the presence of amino groups. Even when the DDA was lowered to 15%, the adsorption capacity reached 940 mg g À1 due to its nanostructural assembly of nanofibers/nanowhiskers, which showed great advantages compared to highly deacetylated chitosan-based adsorbents (DDA > 70%). Considering the issue of environmental protection and adsorption efficiency, DEChNs-Gels have become a potential substitute for chitosan-based adsorbents due to the milder deacetylation process and superior performance, making this material an attractive adsorbent for textile dyes.

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“…Furthermore, ChNFs also could inhibit mucosal inflammation by suppressing the myeloperoxidase-positive cells ( Figure 28G-I). In addition, the oral administration of ChNFs in animal tests has been recognized as emerging in the areas of improved intestinal health, ameliorates renal injury and reduction of obesity [444,445].…”

Section: Applications In Drug Delivery and Oral Administrationmentioning

confidence: 99%

Biopolymer nanofibrils: Structure, modeling, preparation, and applications

Ling

Chen

Fan

et al. 2018

Progress in Polymer Science

340

272

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Biopolymer nanofibrils exhibit exceptional mechanical properties with a unique combination of strength and toughness, while also presenting biological functions that interact with the surrounding environment. These features of biopolymer nanofibrils profit from their hierarchical structures that spun angstrom to hundreds of nanometer scales. To maintain these unique structural features and to directly utilize these natural supramolecular assemblies, a variety of new methods have been developed to produce biopolymer nanofibrils. In particular, cellulose nanofibrils (CNFs), chitin nanofibrils (ChNFs), silk nanofibrils (SNFs) and collagen nanofibrils (CoNFs), as the four most abundant biopolymer nanofibrils on earth, have been the focus of research in recent years due to their renewable features, wide availability, low-cost, biocompatibility, and biodegradability. A series of top-down and bottom-up strategies have been accessed to exfoliate and regenerate these nanofibrils for versatile advanced applications. In this review, we first summarize the structures of biopolymer nanofibrils in nature and outline their related computational models with the aim of disclosing fundamental structure-property relationships in biological materials. Then, we discuss the underlying methods used for the preparation of CNFs, ChNFs, SNF and CoNFs, and discuss emerging applications for these biopolymer nanofibrils.

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An oral absorbent, surface-deacetylated chitin nano-fiber ameliorates renal injury and oxidative stress in 5/6 nephrectomized rats

Cited by 35 publications

References 30 publications

Effect of Indoxyl Sulfate on the Repair and Intactness of Intestinal Epithelial Cells: Role of Reactive Oxygen Species’ Release

Effect of Indoxyl Sulfate on the Repair and Intactness of Intestinal Epithelial Cells: Role of Reactive Oxygen Species’ Release

Adsorption of Reactive Blue 19 from aqueous solution by chitin nanofiber-/nanowhisker-based hydrogels

Biopolymer nanofibrils: Structure, modeling, preparation, and applications

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