An Optoelectronic Spectral Sensor for Monitoring the Elimination of Uremic Markers with Low and Middle Molecular Weight during Hemodialysis Therapy

Zemchenkov, G. A.; Коноплев, Г. А.; Korsakov, Vadim; Kuznetsov, Artur; Roshchina, N. V.; Stepanova, O. S.; Frorip, A.

doi:10.1007/s10527-022-10158-7

Cited by 2 publications

(1 citation statement)

References 23 publications

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“…The interpretation of the second peak is not so obvious. Our proposition about the AGE products is based on preliminary experiments with the fluorescent spectra of the various chromatographic fractions of hemodialysate and AGE products observed during HD [66][67][68][69]; however, additional comprehensive research is needed to fully support this suggestion. The clinical significance of the second and the third peaks in the chromatograms is yet to be investigated; the second peak is of special interest because AGE products are responsible for cardiovascular complications and other pathological conditions in PD patients [70][71][72].…”

Section: Discussionmentioning

confidence: 99%

Optical Chemical Sensor Based on Fast-Protein Liquid Chromatography for Regular Peritoneal Protein Loss Assessment in End-Stage Renal Disease Patients on Continuous Ambulatory Peritoneal Dialysis

Kuznetsov¹,

Frorip²,

Sünter³

et al. 2022

Chemosensors

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Point-of-care testing (POCT) devices are becoming increasingly popular in the medical community as an alternative to conventional laboratory testing, especially for home treatments or other forms of outpatient care. Multiple-use chemical sensors with minimal requirements for disposables are among the most practical and cost-effective POC diagnostic instruments, especially in managing chronic conditions. An affordable, simple, and easy-to-use optical sensor based on fast protein liquid chromatography with direct UV absorption detection was developed for the rapid determination of the total protein concentration in effluent peritoneal dialysate and for the assessment of protein losses in end-stage renal disease (ESRD) patients on constant ambulatory peritoneal dialysis (CAPD). The sensor employs non-disposable PD-10 desalting columns for the separation of molecules with different molecular weights and a deep UV LED (maximum at 285 nm) as a light source for optical detection. The analytic procedure is relatively simple, takes 10–15 min, and potentially can be performed by patients themselves or nursing staff without laboratory training. Preliminary clinical trials on a group of 23 patients on CAPD revealed a good concordance between the protein concentrations in dialysate samples measured with the sensor and an automated biochemical analyzer; the mean relative error was about 10%, which is comparable with routine clinical laboratory methods.

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Section: Discussionmentioning

confidence: 99%

Optical Chemical Sensor Based on Fast-Protein Liquid Chromatography for Regular Peritoneal Protein Loss Assessment in End-Stage Renal Disease Patients on Continuous Ambulatory Peritoneal Dialysis

Kuznetsov¹,

Frorip²,

Sünter³

et al. 2022

Chemosensors

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Optical monitoring of hemodialysis using noninvasive measurement of uric acid in the dialysate

Żyłka,

Tęcza,

Szemela

et al. 2023

Sci Rep

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The aim of this study was to present a methodology for predicting changes in uric acid concentrations in the blood of chronically hemodialyzed patients based on an optical measurement of the intensity of selected wavelengths in the dialysate. Blood samples were taken from the arterial line every 30 min throughout the hemodialysis period, to measure uric acid levels. Simultaneously, optical measurements were made on dialysate flowing from the dialyzer. Uric acid concentration can be measured either directly from the blood or from dialyzer outflow with acceptable error. In addition, both methods reveal any increased dynamics in uric acid concentration in the initial phase of hemodialysis. The wavelength of the light was adjusted for optimal uric acid particle detection. Comparing the uric acid concentration measured in the blood of patients with the intensity of wave absorption in the dialysate, the functional relationship between the uric acid concentration levels was determined. Using the optical method for measuring uric acid concentration in the dialysate, the concentration of uric acid in the blood during hemodialysis can be non-invasively and accurately estimated. This method can be used to assess the adequacy of hemodialysis by computer acquisition of uric acid concentrations determined in on-line dialysate.

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An Optoelectronic Spectral Sensor for Monitoring the Elimination of Uremic Markers with Low and Middle Molecular Weight during Hemodialysis Therapy

Cited by 2 publications

References 23 publications

Optical Chemical Sensor Based on Fast-Protein Liquid Chromatography for Regular Peritoneal Protein Loss Assessment in End-Stage Renal Disease Patients on Continuous Ambulatory Peritoneal Dialysis

Optical Chemical Sensor Based on Fast-Protein Liquid Chromatography for Regular Peritoneal Protein Loss Assessment in End-Stage Renal Disease Patients on Continuous Ambulatory Peritoneal Dialysis

Optical monitoring of hemodialysis using noninvasive measurement of uric acid in the dialysate

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