An optimized method for determination of benzene in exhaled air by gas chromatography–mass spectrometry using solid phase microextraction as a sampling technique

Amorim, Leiliane Coelho André; Carneiro, Joana P.; Cardeal, Zenilda de Lourdes

doi:10.1016/j.jchromb.2008.02.023

Cited by 33 publications

(20 citation statements)

References 21 publications

(25 reference statements)

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“…Moreover, losses of volatile compounds have also been observed when glass bulbs are used as containers, although at lower rates than with polymer bags [46]. In some cases, polymeric chambers [39,40,68,69] have been used to collect breath samples. Unfortunately, no information about losses and stability has been recorded.…”

Section: Breath-collection Devicesmentioning

confidence: 99%

“…These methodologies are based on the direct collection of target VOCs on a sorbent material, which presents better stability and permits longer storage times. A modified holder connected to a SPME fiber has been developed [67,69]. The use of hydrophobic membranes to eliminate water vapor and impurities followed by pre-concentration in a sorbent trap has also been proposed [39,40].…”

Section: Breath-collection Devicesmentioning

confidence: 99%

“…Different procedures are followed in SPME (Table 1) [3,17,35,46,61,66,67,[69][70][71]87,88]. Sometimes the fiber is inserted into the bag or glass bulb containing the total volume of breath collected for a predetermined period of time [46,66,70,71], or a fixed and small volume of the sample is transferred inside a sealed vacuum headspace vial before inserting the SPME fiber into the vial [87,88].…”

Section: Solid-phase Microextraction (Spme)mentioning

confidence: 99%

“…Five categories of study can be found in the literature: (1) simulations in controlled chambers [21,77,82,83]; (2) swimming and domestic water activities [12,24,68,78,84,119]; (3) services related to mechanical vehicles [22,23,28,69,120,121]; (4) solvents and volatile compounds in the workplace [15,19,79,[122][123][124]; and, (5) active and passive smoking [16,20,25,27,29,51,86,125].…”

Section: Applications In Exposure Analysismentioning

confidence: 99%

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Analytical challenges in breath analysis and its application to exposure monitoring

Alonso

Sánchez

2013

TrAC Trends in Analytical Chemistry

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There is an increasing interest in the use of breath analysis for monitoring human physiology and exposure to toxic substances or environmental pollutants.This review focuses on the current status of the sampling procedures, collection devices and sample-enrichment methodologies used for exhaled breath-vapor analysis. We discuss the different parameters affecting each of the above steps, taking into account the requirements for breath analysis in exposure assessments and the need to analyze target compounds at sub-ppbv levels.Finally, we summarize the practical applications of exposure analysis in the past two decades.

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Section: Breath-collection Devicesmentioning

confidence: 99%

Section: Breath-collection Devicesmentioning

confidence: 99%

Section: Solid-phase Microextraction (Spme)mentioning

confidence: 99%

Section: Applications In Exposure Analysismentioning

confidence: 99%

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Analytical challenges in breath analysis and its application to exposure monitoring

Alonso

Sánchez

2013

TrAC Trends in Analytical Chemistry

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“…Nos últimos anos, a exposição ocupacional ao benzeno pela gasolina tem sido objeto de pesquisa, a fim de estabelecer a relação de causa-efeito a partir de fontes de exposição ambiental e ocupacional [5][6][7][8] .…”

Section: Introductionunclassified

Avaliação da exposição ocupacional ao benzeno em trabalhadores frentistas e analistas de combustíveis utilizando o Teste Cometa como biomarcador de genotoxicidade

Campos

Fernandes

André

2017

Rev. bras. saúde ocup.

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Resumo Introdução: frentistas e analistas de combustíveis estão expostos a vários compostos orgânicos voláteis presentes na gasolina, incluindo benzeno, que se destaca por sua importância toxicológica. Objetivo: avaliar a exposição ocupacional ao benzeno na gasolina, utilizando o Teste Cometa como biomarcador de genotoxicidade em comparação ao ácido trans,trans-mucônico urinário (AttM) como biomarcador de exposição ao benzeno. Métodos: estudo de corte transversal com análises de biomarcadores de exposição e de genotoxicidade em grupo de expostos ocupacionalmente ao benzeno através da gasolina e grupo controle. Resultados: o Teste Cometa mostrou uma média (desvio padrão) de índice de dano, expresso em unidades arbitrárias, no grupo exposto de 28,4 (10,1) significativamente mais elevado do que no grupo não-exposto, 18,4 (10,1). O AttM urinário, em mg/g de creatinina, foi significativamente maior no grupo exposto, 1,13 (0,45), em relação ao grupo não exposto, 0,44 (0,33). Os dois biomarcadores apresentaram boa correlação linear (r=0,81; p<0,05), indicando uma forte associação entre o biomarcador de exposição e o biomarcador de efeito. Conclusão: os resultados sugerem que uma maior exposição ocupacional ao benzeno está associada a um risco aumentado de dano genotóxico entre indivíduos expostos à gasolina.

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Pervasive Healthcare System Based on Environmental Monitoring

Sangeetha

Amudha

2019

Intelligent Pervasive Computing Systems for Smarter Healthcare

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An optimized method for determination of benzene in exhaled air by gas chromatography–mass spectrometry using solid phase microextraction as a sampling technique

Cited by 33 publications

References 21 publications

Analytical challenges in breath analysis and its application to exposure monitoring

Analytical challenges in breath analysis and its application to exposure monitoring

Avaliação da exposição ocupacional ao benzeno em trabalhadores frentistas e analistas de combustíveis utilizando o Teste Cometa como biomarcador de genotoxicidade

Pervasive Healthcare System Based on Environmental Monitoring

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