“…Recovery that has been found appears to correlate with a variety of mechanistic processes including dendritic remodeling, synaptogenesis, axonal sprouting and angiogenesis in peri-infarct regions. Nevertheless, our understanding of the mechanisms underlying re-organization and plasticity still remains unclear but points to plasticity within these areas as a target for therapeutic intervention (Carmichael et al, 2016; Iaci et al, 2016; Liu & Chopp, 2015; Meng et al, 2014; Barratt et al, 2014; Nouri & Cramer, 2011; Benowitz & Carmichael, 2010; Iaci et al, 2010; Benowitz & Carmichael, 2010; Beck & Plate, 2009; Zhang & Chopp, 2009; Cramer, 2008a,b, 2011; Buga et al, 2008; Carmichael, 2006; Li & Carmichael, 2006; Hayashi et al, 2003; Carmichael & Chesselet, 2002; Beck et al, 2000; Marti et al, 2000; Stroemer et al, 1998; Benowitz & Routtenberg, 1997). Indeed, a variety of agents that promote plasticity have enhanced functional recovery in rodent models of ischemic stroke (Duricki et al, 2016; George & Steinberg, 2015; Chollet et al, 2014; Dachir et al, 2014; Dhawan et al, 2011; Zai et al, 2009; Papadopoulos, 2009).…”