A decision support system, including a multi-objective optimization framework and a multi-attribute decision making approach is proposed for satellite equipment layout. Firstly, given three objectives (to minimize the C.G. offset, the cross moments of inertia and the space debris impact risk), we develop a threedimensional layout optimization model. Unlike most of the previous works just focusing on mass characteristics of the system, a space debris impact risk index is developed. Secondly, we develop an efficient optimization framework for the integration of computer-aided design (CAD) software as well as the optimization algorithm to obtain the Pareto front of the layout optimization problem. Thirdly, after obtaining the candidate solutions, we present a multi-attribute decision making approach, which integrates the smart Pareto filter and the correlation coefficient and standard deviation (CCSD) method to select the best tradeoff solutions on the optimal Pareto fronts. Finally, the framework and the decision making approach are applied to a case study of a satellite platform.