An optical coherence photoacoustic microscopy system using a fiber optic sensor

Deng, Shiyu; Haindl, Richard; Zhang, Edward; Beard, Paul C.; Scheuringer, Eva; Sturtzel, Caterina; Qian, Li; Deloria, Abigail J.; Sattmann, Harald; Leitgeb, Rainer A.; Yuan, Zhen; Schmetterer, Leopold; Pramanik, Manojit; Distel, Martin; Drexler, Wolfgang; Li, Mengyang

doi:10.1063/5.0059351

Cited by 13 publications

(7 citation statements)

References 50 publications

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“…We propose a low coherence Doppler lidar (LCDL) that is based on a low coherence optical interferometer 29,30 . Doppler lidars can be classified into continuous wave laser and pulsed wave laser use 13 .…”

Section: Low Coherence Doppler Lidarmentioning

confidence: 99%

Dust flow analysis by low coherence Doppler lidar

Okubo

Lagrosas

Shiina

2023

Sci Rep

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Visualization of dust flow and wind dynamics near the ground surface are essential for understanding the mixing and interaction between geosphere and atmosphere near the surface. Knowing the temporal dust flow is beneficial in dealing with air pollution and health issues. Dust flows near the ground surface are difficult to monitor because of their small temporal and spatial scale. In this study, we propose a low-coherence Doppler lidar (LCDL) for measuring dust flow near the ground with high temporal and spatial resolutions of 5 ms and 1 m, respectively. We demonstrate the performance of LCDL in laboratory experiments using flour and calcium carbonate particles released into the wind tunnel. LCDL experiment results show a good agreement with anemometer measurement in wind speeds ranging from 0 to 5 m/s. The LCDL technique can reveal dust’s speed distribution, which is affected by mass and particle size. As a result, different speed distribution profiles can be used to determine dust type. The simulation results of dust flow coincide well with the experimental results.

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Section: Low Coherence Doppler Lidarmentioning

confidence: 99%

Dust flow analysis by low coherence Doppler lidar

Okubo

Lagrosas

Shiina

2023

Sci Rep

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“…The employed light source is a combined monolithic Super Luminescent Diode (SLED). 2,3 It features three spectrally displaced single super luminescent diodes (SLDs) which are optically combined to gain an extended spectral response by using micro opto-mechanics instead of optical fibers. The system specifications of both the UHR-OCT as well as the pharmaceutical OCT can be found in figure 1 (upper right table).…”

Section: Oct Systemmentioning

confidence: 99%

Investigation of thin pharmaceutical coatings with ultra-high-resolution optical coherence tomography

Haindl,

Kern,

Deng

et al. 2023

Optical Coherence Imaging Techniques and Imaging in Scattering Media V

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Optical Coherence Tomography (OCT) recently attracted attention for the quality control of pharmaceutical film-coatings. Current research focuses on single-layered tablet coatings with layer thicknesses between 50 and 100 µm and production end-point detection using commercial systems available for such applications. Modern multi-particulate dosage forms, particularly interesting for pediatric and personalized medicine, show coating layer thicknesses of 20 µm and below, pushing the limits of commercial pharmaceutical industrial OCT systems, which are namely their spatial and temporal resolutions. We present a novel ultra-high-resolution (UHR-) OCT prototype investigating merits and constraints of the technology based on imaging and semi-automatic layer thickness segmentation and quantification of exemplary multi-particulate dosage forms with different layer structures and layer thicknesses in a range from 7 to 50 µm. The UHR-OCT system allows, for the first time, imaging of morphological features and defects within thin pharmaceutical coatings, accurate film thickness measurements and the quantitative analyses of coating layer variability. Our investigation showcases that UHR-OCT can be the next logical and necessary step to advance quality control in pharmaceutical settings.

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“…We then fill the chamber with the liquid (distilled water, tap water or 1X PBS), place the sample inside and seal the front with a coverslip. The setup [49] (as illustrated in Fig. 7) used in this 703 work is a spectral domain OCM system using a com-…”

Section: Operation For Multi-angle Imagingmentioning

confidence: 99%

Ultrasound-Induced Reorientation for Multi-Angle Optical Coherence Tomography

Kvåle Løvmo,

Deng,

Moser

et al. 2023

Preprint

Self Cite

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Organoid and spheroid technology have recently provided great insights into oncology, developmental biology as well as personalized medicine. Among the methods to optically monitor the structural and functional organization of such samples, optical coherence tomography (OCT) has emerged as an excellent, label-free approach. Mature organoids, however, are often too opaque for OCT due to regions of strong attenuation. This leads to severe artifacts and reduced morphological tissue information in the reconstruction, since the far-side of the specimen is not reachable. Access to multi-angle views of OCT is therefore highly desirable. This aligns with another problem affecting certain goals of organoid research: The sample needs to be embedded in a growth scaffold such as Matrigel, whereas freely floating objects would not suffer from confinement and be more easily accessible for mechanical or chemical probing. Here we present ULTrasound-Induced reorientation for Multi-Angle-OCT (ULTIMA-OCT), a solution overcoming these limitations. By inserting a small 3D-printed acoustic trap to a spectral-domain OCT system, acoustic actuation enables contact-free levitation and finely tunable stepwise reorientation of samples such as zebrafish larvae and tumor spheroids, in a controlled and reproducible manner. This enables tomographic reconstruction of (sub-)mm samples with enhanced penetration depth and reduced attenuation artifacts, by means of a model-based algorithm we developed. We show that this approach is able to fuse the diverse multi-angle OCT volumes for a joint recovery of 3D-reconstruction of reflectivity, attenuation, refractive index and position registration for zebrafish larvae. We believe that our approach represents a powerful enabling tool for developmental biology and organoid research.

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An optical coherence photoacoustic microscopy system using a fiber optic sensor

Cited by 13 publications

References 50 publications

Dust flow analysis by low coherence Doppler lidar

Dust flow analysis by low coherence Doppler lidar

Investigation of thin pharmaceutical coatings with ultra-high-resolution optical coherence tomography

Ultrasound-Induced Reorientation for Multi-Angle Optical Coherence Tomography

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