An Ophthalmological Complication: Central Serous Chorioretinopathy in a Renal Transplant Recipient

Central Serous Chorioretinopathy After Renal Transplantation

“…We found a total of 51 patients with solid-organ transplant-associated CSC in English literature, of which 42 (82%) were RT recipients. 1,9,[11][12][13][14][15][16][17][18][19] Fawzi et al 9 identified 15 patients with CSC after solid-organ transplantation, and in 13 (87%) of these patients CSC occurred after RT. Overrepresentation of RT recipients in their cohort was not explained by factors related to improved survival, enhanced quality of life, or ability to return for follow-up, and the authors suggested that RT recipients may be predisposed to CSC because of their underlying renal disease, the vascular effects of hemodialysis, or the high prevalence of systemic hypertension in patients with end-stage renal disease.…”

“…10 The pathogenesis of CSC remains poorly understood, and in the setting of systemic disorders requiring corticosteroids for therapy, the situation is even further complicated because development of CSC can be related to the underlying disorder, its treatment, or both. Corticosteroids have been suggested to be a common factor in previous reports 1, [11][12][13][14][15][16][17][18][19] on organ transplant-associated CSC, but Fawzi et al 9 recently reported the development of CSC in an RT recipient while on cyclosporine alone without corticosteroids in their cohort of 15 patients. Combined effects of emotional stress, systemic hypertension, and high doses of corticosteroids have generally been thought to contribute to the development of CSC in solid-organ transplant receipients.…”

Central serous chorioretinopathy: Recent findings and new physiopathology hypothesis

“…Organ transplant procedures require treatments with high doses of glucocorticoids and vasopressive catecholamines and stimulate the endogenous production of stress hormones increasing the risk of CSCR. Indeed, there are numerous reports of CSCR following organ transplantation, the more frequently involved interventions being: kidney, bone marrow and heart transplantations (Chaine et al, 2001;Cheng et al, 2002;Chung et al, 2007;Farzan et al, 2014;Fawzi et al, 2006;Fawzi and Cunningham, 2001;Friberg and Eller, 1990;Kamoun et al, 2005;Karashima et al, 2002;Kian-Ersi et al, 2008;Moon and Mieler, 2003;Oliaei et al, 2007;Polak et al, 1995;Sabet-Peyman et al, 2012;Singh et al, 2003). Finally, allergy has been suggested to favor CSCR, yet various allergic manifestations are managed with local or systemic corticosteroids and the distinction between the contribution of allergy or its treatment remains to be determined (Edalati et al, 2009).…”

Mixed Retinopathy: A Unique Presentation

“…Central serous chorio-retinopathy (CSR) could have been one of the diagnoses in our case considering it presents with stress, anxiety, corticosteroid use, toxicity of immunosuppressive drugs, such as cyclosporine and tacrolimus. 10 In the absence of typical leak pattern and resolving sub retinal fluid (SRF) even on steroid continuation, it makes it an unlikely diagnosis in our case.…”