An Open Trial of Valproate for Agitation in Geriatric Neuropsychiatric Disorders

Sodium valproate in the treatment of aggressive behavior in patients with dementia—a randomized placebo controlled clinical trial

“…Open studies and case reports suggest sodium valproate to be effective in dementia in the treatment of aggressive behavior (Mazure et al, 1992;Mellow et al, 1993;Horne and Lindley, 1995;Sandborn et al, 1995;Haas et al, 1997), agitation (Lott et al, 1995;Kasckow et al, 1997;Porsteinsson et al, 1997;Hermann, 1998), both agitation and aggression (Sival et al, 1994;Gupta et al, 1998;Buchater and Lantz, 2001) and behavioral disturbance (Narayan and Nelson, 1996;Kunik et al, 1998;Goldberg, 1999). In these reports the prescribed daily dose varied widely between 240 and 4000 mg.…”

Tratamento da doença de Alzheimer: recomendações e sugestões do Departamento Científico de Neurologia Cognitiva e do Envelhecimento da Academia Brasileira de Neurologia

“…Em geral são bem tolerados e produzem pouca toxicidade, sendo utilizados de modo crescente no tratamento de a l g u n s dos SCPD. Os anticonvulsivantes mais estudados foram a c a r b a m a z e p i n a (200-800 mg/dia) 6 7 , 6 8 e o ácido valpróico (250-1.000 mg/dia) [69][70][71] .…”

Recognition and Management of Behavioral Disturbances in Dementia

“…136 Divalproex at doses of 150 to 250 mg decreased agitation and aggression in one pilot study. 137 The elderly may have a higher risk of developing thrombocytopenia with valproate. 138 Gabapentin has also been found to be useful in reducing agitation and aggression in patients with dementia.…”