An open study of vitamin D3 treatment in psoriasis vulgaris

Morimoto, Shigeto; Yoshikawa, Kunihiko; Kozuka, T; Kitano, Yukio; Imanaka, Shunji; Fukuo, Keisuke; Koh, Eio; Kumahara, Yuichi

doi:10.1111/j.1365-2133.1986.tb06236.x

Cited by 196 publications

(78 citation statements)

References 40 publications

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“…Therefore, it is speculated that VitD3 derivatives may be useful for the therapy of Th1-dependent immune diseases. Indeed, recently, it has been reported that VitD3 derivative is effective against psoriasis in human and experimental autoimmune encephalomyelitis in animal models (4,5,18,23). However, the precise mechanism has remained unclear yet.…”

Section: Discussionmentioning

confidence: 99%

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Immunomodulating effect of vitamin D3 derivatives on type-1 cellular immunity

et al. 2006

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ABSTRACT1α,25-dihydroxyvitamin D3 [Calcitriol or 1,25(OH) 2 D 3 ] is an important active metabolite involved in multiple functions but its calcemic effect in vivo limits its therapeutic applications. On the other hand, 22-oxa-1α,25-dihydroxyvitamin D 3 (22-oxacalcitriol or 22-Oxa-1α,25-D 3 ), a low calcemic analog of vitamin D3 (VitD3), has been widely used as a drug for the secondary hyperparathyroidism. Here, we investigated immunomodulating effect of these two VitD3 derivatives on the differentiation of type-1 immunoregulatory cells such as dendritic cells (DC1), cytotoxic T cells (Tc1) and helper T cells (Th1). BALB/c mouse bone marrow-derived DC (BMDC1) induced by culture with Th1 condition (GM-CSF, IL-3, IL-12 and IFN-γ) expressed higher levels of MHC Class I and Class II molecules and co-stimulatory molecules compared with BMDC0 induced by neutral condition (GM-CSF + IL-3). In addition, BMDC1 showed stronger immunostimulating activity to induce alloantigen (H-2 d )-specific cytotoxic T lymphocytes (CTL) compared with BMDC0. However, if VitD3 derivatives were added into the culture for BMDC1 induction, the expression of functional molecules and type-1 IFNs were greatly inhibited. Moreover, VitD3 derivative-treated BMDC1 lost their immunostimulating activity to induce alloantigen-specific IFN-γ-producing Tc1. In addition, it was demonstrated that the addition of VitD3 derivatives inhibited the differentiation of IFN-γ-producing Th1 cells from ovalbumin (OVA)-specific naive Th cells, while it rather augmented the differentiation of IL-4-or IL-10-producing Th2 cells. There was no significant difference in immunomodulating activity between 1,25(OH) 2 D 3 and 22-Oxa-1α,25-D 3 . Thus, VitD3 derivatives are demonstrated to inhibit the functional differentiation of DC1, Tc1 and Th1 cells, which play a critical role in type-1 cellular immune responses.

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Section: Discussionmentioning

confidence: 99%

“…Psoriasis is an autoimmune disease, which is induced by abnormal acceleration of type-1 immune responses (14). Recently, it has been reported that topical 22-Oxa-1α,25-D 3 (maxacalcitol) is effective for the treatment of psoriasis (4,18). It remains unclear how VitD3 derivatives show their therapeutic effect against psoriasis.…”

Section: Discussionmentioning

confidence: 99%

Immunomodulating effect of vitamin D3 derivatives on type-1 cellular immunity

et al. 2006

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“…Furthermore, vitamin D inhibits the activation of TNF alpha converting enzyme (TACE) [32]. TACE activation in renal cells gives rise to subsequent release of TNF-alpha, ICAM-1, and VCAM-1 into the circulation, promoting systemic inflammation.…”

Section: Cd4mentioning

confidence: 99%

“…However, activation of TACE can be blocked by active vitamin D preparations [33]. TACE activation is usually secondary to activation of the renal RAS system, which is also directly inhibited by VDR activation [32,34]. Thus, vitamin D suppresses TACE activation and subsequent inflammation on multiple levels.…”

Section: Cd4mentioning

confidence: 99%

Infection Inflammation and Vitamin D

K¹

2012

Clin Microbial

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“…A variety of studies have shown that oral vitamin D supplementation and vitamin D analogues have favorable clinical responses and maintain a similar safety profile to topical forms. Although patients did not experience adverse outcomes, the risk of hypercalcemia and bone demineralization is theoretically possible [38][39][40][41]. With the literature support for oral vitamin D, the next step is producing a vitamin D analog that can target the underlying pathophysiology of psoriatic lesions while minimizing adverse effects.…”

Section: Vitamin Dmentioning

confidence: 99%

Psoriasis and Fat-soluble Vitamins: A Review

Usedom¹,

Neidig²,

Allen³

2017

J Clin Exp Dermatol Res

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Fat-soluble vitamins exhibit numerous routes of immune modulation and specifically alter a variety of pathways in psoriasis pathology. Psoriasis, a chronic immune-mediated disease, often requires a combination of topical, oral, and occasionally, subcutaneous or intravenous therapies making disease management complex. With the complexity of treatment, patient adherence is reduced. Vitamin supplementation as an adjunctive treatment would minimize potential adverse effects from systemic medication, increase patient adherence and decrease overall cost. While vitamin A and D are effective topically, oral supplementation is not currently a mainstay of therapy although data exists to support such supplementation. Data on vitamin E and K implicate the significant role each has in the alteration of the inflammatory cascade responsible for psoriasis. Research showing fat-soluble vitamin deficiency in psoriasis exists and presents greater evidence for oral vitamin treatment in addition to first-line therapies. This review presents the mechanism of action in psoriasis of each fat-soluble vitamin and the data on the efficacy of oral fat-soluble vitamin supplementation in psoriasis and systemic inflammation. We also present fat-soluble vitamin deficiency data shown in psoriasis patients. With the evidence of their targeted mechanism of action, efficacy data with oral supplementation, and evidence of deficiency in patients, oral fat-soluble vitamins should be considered as an adjunct to therapy in psoriasis patients.

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An open study of vitamin D3 treatment in psoriasis vulgaris

Cited by 196 publications

References 40 publications

Immunomodulating effect of vitamin D3 derivatives on type-1 cellular immunity

Immunomodulating effect of vitamin D3 derivatives on type-1 cellular immunity

Infection Inflammation and Vitamin D

Psoriasis and Fat-soluble Vitamins: A Review

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